Simultaneous and Continuous Measurement of Free Concentration of Valproate in Blood and Extracellular Space of Rat Cerebral Cortex

Ion diffusion modified by tortuosity and volume fraction in the extracellular microenvironment of the rat cerebellum.

1981 • 781 citations

Antiepileptic drugs : mechanisms of action

1980 • 508 citations

Mechanism of anticonvulsant action of valproate

1982 • 344 citations

Cerebral pO₂, pCO₂ and pH: Changes During Convulsive Activity and their Significance for Spontaneous Arrest of Seizures

1972 • 182 citations

Volume Transmission in the Brain

1992 • 169 citations

The Extracellular Space in the Vertebrate Central Nervous System

1972 • 156 citations

Problems in GABA Research from Brain to Bacteria

1983 • 144 citations

Anion permeability in spreading depression investigated with ion-sensitive microelectrodes

1979 • 127 citations

Blood–Brain Barrier Transport of Valproic Acid

1985 • 108 citations

Distribution of valproic acid and its metabolites in various brain areas of dogs and rats after acute and prolonged treatment.

1983 • 85 citations

Human brain, plasma, and cerebrospinal fluid concentration of sodium valproate after 72 hours of therapy

1981 • 63 citations

Kinetics of Penetration of Common Antiepileptic Drugs into Cerebrospinal Fluid

1984 • 57 citations

Effects of Valproate in a Model Nervous System (Buccal Ganglia of Helix Pomatia): I. Antiepileptic Actions

1992 • 43 citations

Low and variable presence of valproic acid in human brain

1992 • 42 citations

A comparative study of the protein binding of anticonvulsant drugs in serum of dog and man.

1979 • 42 citations

Plasma protein‐binding and CSF concentrations of valproic acid in man following acute oral dosing.

1983 • 41 citations

Comparative Pharmacodynamics and Brain Distribution of E‐δ²‐Valproate and Valproate in Rats

1991 • 39 citations

Penetration of Valproate and its Active Metabolites into Cerebrospinal Fluid of Children with Epilepsy

1988 • 34 citations

Human brain, plasma, and cerebrospinal fluid concentration of sodium valproate after 72 hours of therapy

1981 • 31 citations

Simultaneous and Continuous Measurement of Choroid Plexus Blood Flow and Cerebrospinal Fluid Production: Effects of Vasoactive Intestinal Polypeptide

1991 • 31 citations

The Extracellular Concentration of the Anti-epileptic Drug Valproate in the Rat Brain as Determined with Microdialysis and an Automated HPLC Procedure

1991 • 15 citations

Diffusion analysis of valproate andtrans-2-en-valproate in agar and in cerebral cortex of the rat

1993 • 15 citations

The relationship between plasma concentration of valproic acid and its anticonvulsant and behavioural effects in the rat

1982 • 14 citations

Cerebral blood flow, glucose use and CSF ionic regulation in potassium-depleted rats

1988 • 1 citations