Penetration of Valproate and its Active Metabolites into Cerebrospinal Fluid of Children with Epilepsy

Valproic acid and its metabolites: placental transfer, neonatal pharmacokinetics, transfer via mother's milk and clinical status in neonates of epileptic mothers.

1981 • 226 citations

Sodium Valproate in Treatment of Epilepsy

1974 • 172 citations

Valproic Acid and Metabolites: Pharmacological and Toxicological Studies

1984 • 145 citations

Problems in GABA Research from Brain to Bacteria

1983 • 144 citations

Monoamine and GABA metabolism and the anticonvulsant action of DI-n-propylacetate and ethanolamine-O-sulphate

1977 • 113 citations

Valproic acid in the perinatal period: Decreased maternal serum protein binding results in fetal accumulation and neonatal displacement of the drug and some metabolites

1984 • 111 citations

Valproic acid: brain and plasma levels of the drug and its metabolites, anticonvulsant effects and gamma-aminobutyric acid (GABA) metabolism in the mouse.

1982 • 111 citations

A Controlled Study of the Effect of Sodium Valproate on Photosensitive Epilepsy and Its Prognosis

1978 • 110 citations

Blood–Brain Barrier Transport of Valproic Acid

1985 • 108 citations

The Delayed Effect of Sodium Valproate on the Photoconvulsive Response in Man

1979 • 108 citations

Epilepsy—A Window to Brain Mechanisms

1981 • 99 citations

Valproic acid and several metabolites: quantitative determination in serum, urine, breast milk and tissues by gas chromatography—mass spectrometry using selected ion monitoring

1981 • 98 citations

Distribution of valproate across the interface between blood and cerebrospinal fluid

1978 • 86 citations

Distribution of valproic acid and its metabolites in various brain areas of dogs and rats after acute and prolonged treatment.

1983 • 85 citations

Human brain, plasma, and cerebrospinal fluid concentration of sodium valproate after 72 hours of therapy

1981 • 63 citations

Kinetics of Penetration of Common Antiepileptic Drugs into Cerebrospinal Fluid

1984 • 57 citations

Transport of GABA at the Blood‐CSF Interface

1982 • 48 citations

Effect of metabolites of valproic acid on the metabolism of GABA in brain and brain nerve endings

1981 • 44 citations

A comparative study of the protein binding of anticonvulsant drugs in serum of dog and man.

1979 • 42 citations

Anticonvulsant activity of metabolites of valproic acid.

1981 • 42 citations

Valproic acid: metabolite concentrations in plasma and brain, anticonvulsant activity, and effects on GABA metabolism during subacute treatment in mice.

1982 • 41 citations

Plasma protein‐binding and CSF concentrations of valproic acid in man following acute oral dosing.

1983 • 41 citations

Brain binding of anticonvulsants

1980 • 31 citations

Human brain, plasma, and cerebrospinal fluid concentration of sodium valproate after 72 hours of therapy

1981 • 31 citations

Accumulation and Washout Kinetics of Valproic Acid and Its Active Metabolites

1986 • 30 citations

Sodium valproate in the management of intractable epilepsy: comparison with clonazepam.

1975 • 9 citations

Valproate metabolite concentrations in brain increase with chronic administration of sodium valproate

1985 • 6 citations

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