Explanation at the opioid receptor level for differing toxicity of morphine and morphine 6-glucuronide

Endogenous opioid peptides: multiple agonists and receptors

1977 • 2,494 citations

Multiple opiate receptors. Enkephalins and morphine bind to receptors of different specificity.

1979 • 684 citations

The effects of morphine and nalorphine-like drugs in the nondependent, morphine-dependent and cyclazocine-dependent chronic spinal dog.

1976 • 467 citations

Stereospecific and Nonspecific Interactions of the Morphine Congener Levorphanol in Subcellular Fractions of Mouse Brain

1971 • 413 citations

Pharmacological characterization of morphine-6 beta-glucuronide, a very potent morphine metabolite.

1989 • 373 citations

Classification of multiple morphine and enkephalin binding sites in the central nervous system.

1981 • 372 citations

Analgesic Effect of Morphine Glucuronides

1971 • 367 citations

Morphine-6-glucuronide, a potent mu agonist

1987 • 365 citations

Minireview: Multiple MU opiate receptors

1986 • 348 citations

Separation of opioid analgesia from respiratory depression: evidence for different receptor mechanisms.

1985 • 271 citations

Opiate Analgesia: Evidence for Mediation by a Subpopulation of Opiate Receptors

1980 • 249 citations

Specificity of opioids towards the μ-, δ- and ϵ-opiate receptors

1979 • 194 citations

Morphine-6-glucuronide: Analgesic effects and receptor binding profile in rats

1988 • 191 citations

Dissociation of morphine's analgesic and respiratory depressant actions

1983 • 128 citations

Allosteric coupling between morphine and enkephalin receptors in vitro.

1982 • 116 citations

EXPLANATION FOR POTENCY OF REPEATED ORAL DOSES OF MORPHINE?

1987 • 110 citations

Modulation of μ-mediated antinociception by δ agonists in the mouse: selective potentiation of morphine and normorphine by [D-Pen2, D-Pen5]enkephalin

1989 • 99 citations

Kappa-opioid receptor-mediated antinociception in the rat. II. Supraspinal in addition to spinal sites of action.

1989 • 75 citations

Different effects of μ and δ opiate agonists on respiration

1984 • 75 citations

Enhanced binding of morphine and nalorphine to opioid delta receptor by glucuronate and sulfate conjugations at the 6-position

1987 • 70 citations

Can supraspinal δ-opioid receptors mediate antinociception?

1988 • 66 citations

Upregulation of opioid receptor subtypes correlates with potency changes of morphine and dadle

1988 • 65 citations

Long lasting respiratory depression induced by morphine‐6‐glucuronide?

1989 • 60 citations

Benzomorphan binding sites in rat lumbo-sacral spinal cord

1982 • 47 citations

Interaction of naloxone with μ- and δ-opioid agonists on the respiration of rats

1983 • 46 citations

C57BL/6J-bg J (beige) mice: Differential sensitivity in the tail flick test to centrally administered MU- and delta-opioid receptor agonists

1987 • 41 citations

Opioid Analgesics and Antagonists

2008 • 33 citations

A comparative study in rats of the respiratory depression and analgesia induced by μ- and δ-opioid agonists

1984 • 30 citations

Morphine intoxication in renal failure; the role of morphine-6-glucuronide.

1986 • 26 citations