The analgesic activity of morphine‐6‐glucuronide.

Morphine and metabolite behavior after different routes of morphine administration: Demonstration of the importance of the active metabolite morphine-6-glucuronide

1990 • 446 citations

Pharmaceutics: The science of dosage form design

1989 • 402 citations

Analgesic Effect of Morphine Glucuronides

1971 • 367 citations

Morphine-6-glucuronide, a potent mu agonist

1987 • 365 citations

Minireview: Multiple MU opiate receptors

1986 • 348 citations

Determination of morphine, morphine-3-glucuronide and (tentatively) morphine-6-glucuronide in plasma and urine using ion-pair high-performance liquid chromatography

1982 • 278 citations

Opiate Analgesia: Evidence for Mediation by a Subpopulation of Opiate Receptors

1980 • 249 citations

The Metabolism of Morphine and Heroin in Man

1975 • 215 citations

Reassessment of verbal and visual analog ratings in analgesic studies

1985 • 166 citations

A REVIEW OF THE CHEMICAL FEATURES ASSOCIATED WITH STRONG MORPHINE-LIKE ACTIVITY

1962 • 135 citations

ANALGESIC EFFICACY AND CSF PHARMACOKINETICS OF INTRATHECAL MORPHINE-6-GLUCURONIDE: COMPARISON WITH MORPHINE

1990 • 119 citations

STRIPE: An interactive computer program for the analysis of drug pharmacokinetics

1983 • 113 citations

An improved method for the simultaneous determination of morphine and its principal glucuronide metabolites

1988 • 98 citations

Distribution and fate of morphine in non-tolerant and tolerant dogs and rats.

1954 • 90 citations

Morphine-6-Glucuronide might Mediate the Prolonged Opioid Effect of Morphine in Acute Renal Failure

1990 • 78 citations

DISPOSITION OF MORPHINE-6-GLUCURONIDE AND MORPHINE IN HEALTHY VOLUNTEERS

1991 • 72 citations

Enhanced binding of morphine and nalorphine to opioid delta receptor by glucuronate and sulfate conjugations at the 6-position

1987 • 70 citations

Metabolism of Drugs. LXIX. Studies on the Urinary Metabolites of Morphine in Several Mammalian Species

1970 • 66 citations

Steady-state kinetics and analgesic effect of oral morphine in cancer patients

1983 • 61 citations

Chemical synthesis and analgesic effect of morphine ethereal sulfates

1972 • 61 citations

Autoradiographic evidence for two classes of mu opioid binding sites in rat brain using [125I]FK33824

1987 • 58 citations

Metabolism of Drugs. LX. The Synthesis of Codeine and Morphine Glucuronides

1968 • 53 citations

PHARMACOKINETICS AND ANALGESIC EFFECT OF SLOW-RELEASE ORAL MORPHINE SULPHATE IN VOLUNTEERS

1984 • 53 citations

VENTILATORY EFFECTS AND PLASMA CONCENTRATION OF MORPHINE IN MAN

1978 • 52 citations

Opiate Structure and Activity???A Guide to Understanding the Receptor

1984 • 45 citations

Analgesic Potencies of Morphine 3- and 6-Sulfates After Intracerebroventricular Administration in Mice: Relationship to Structural Characteristics Defined by Mass Spectrometry and Nuclear Magnetic Resonance

1985 • 40 citations

CSF and plasma morphine concentrations in cancer patients during chronic epidural morphine therapy and its relation to pain relief

1987 • 37 citations

Gene expression in oestrogen-dependent human breast cancer xenograft tumours

1990 • 25 citations

CSF and plasma pharmacokinetics of intramuscular morphine

1985 • 25 citations

Comparative opiate receptor subsite affinities of morphine and morphine-6-Glucuronide

1990 • 5 citations

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