Dysregulated expression of growth factors and their receptors in the development of prostate cancer

Plasma Insulin-Like Growth Factor-I and Prostate Cancer Risk: A Prospective Study

1998 • 2,010 citations

Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma.

1993 • 1,646 citations

Structural Characterization and Biological Functions of Fibroblast Growth Factor

1987 • 1,299 citations

STRUCTURE AND FUNCTION OF THE MANNOSE 6-PHOSPHATE/INSULINLIKE GROWTH FACTOR II RECEPTORS

1992 • 1,056 citations

A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences

1986 • 795 citations

The Insulin-Like Growth Factors

1993 • 647 citations

Insulin-Like Growth Factor 1 and Prostate Cancer Risk: A Population-Based, Case-Control Study

1998 • 592 citations

Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma.

1992 • 478 citations

Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy.

1993 • 408 citations

ELEVATED LEVELS OF CIRCULATING INTERLEUKIN-6 AND TRANSFORMING GROWTH FACTOR-beta 1 IN PATIENTS WITH METASTATIC PROSTATIC CARCINOMA

1999 • 379 citations

K-252a inhibits nerve growth factor-induced trk proto-oncogene tyrosine phosphorylation and kinase activity.

1992 • 368 citations

Insulin-Like Growth Factors (IGFs), IGF Receptors, and IGF-Binding Proteins in Primary Cultures of Prostate Epithelial Cells*

1991 • 361 citations

Hepatocyte growth factor and its receptor (c-MET) in prostatic carcinoma.

1995 • 329 citations

Comparison of microscopic vascularity in benign and malignant prostate tissue

1993 • 327 citations

Characterization of Recombinant Human Fibroblast Growth Factor (FGF)-10 Reveals Functional Similarities with Keratinocyte Growth Factor (FGF-7)

1998 • 307 citations

Heparin-binding keratinocyte growth factor is a candidate stromal-to-epithelial-cell andromedin.

1992 • 287 citations

Vascular Endothelial Growth Factor (VEGF) Expression in Human Prostate Cancer: In Situ and in Vitro Expression of VEGF by Human Prostate Cancer Cells

1997 • 286 citations

Requirement of ErbB2 for signalling by interleukin-6 in prostate carcinoma cells

1998 • 282 citations

Biological effects of prostate specific antigen as an insulin-like growth factor binding protein-3 protease

1994 • 273 citations

C-met Proto-Oncogene Expression in Benign and Malignant Human Prostate Tissues

1995 • 267 citations

Neutralizing anti-vascular endothelial growth factor antibody completely inhibits angiogenesis and growth of human prostate carcinoma micro tumors in vivo

1998 • 248 citations

The Biologic Effects of C225, A Chimeric Monoclonal Antibody to the EGFR, on Human Prostate Carcinoma

1996 • 243 citations

Inhibition of growth of prostatic cancer cell lines by peptide analogues of insulin-like growth factor 1.

1993 • 240 citations

Serum insulin-like growth factor-binding protein-2 (IGFBP-2) is increased and IGFBP-3 is decreased in patients with prostate cancer: correlation with serum prostate-specific antigen.

1993 • 227 citations

Prevention of cell death induced by tumor necrosis factor alpha in LNCaP cells by overexpression of sulfated glycoprotein-2 (clusterin).

1995 • 224 citations

Changing pattern of expression of the epidermal growth factor receptor and transforming growth factor alpha in the progression of prostatic neoplasms.

1995 • 216 citations

Insulin‐like growth factor I: Action and receptor characterization in human prostate cancer cell lines

1993 • 215 citations

Direct demonstration of rapid insulin-like growth factor II Receptor internalization and recycling in rat adipocytes. Insulin stimulates 125I-insulin-like growth factor II degradation by modulating the IGF-II receptor recycling process.

1985 • 203 citations

Elevated levels of insulin-like growth factor-binding protein-2 in the serum of prostate cancer patients.

1993 • 201 citations

Genetic change in transforming growth factor beta (TGF-beta) receptor type I gene correlates with insensitivity to TGF-beta 1 in human prostate cancer cells.

1996 • 195 citations

Alternative splicing of fibroblast growth factor receptor 2 (FGF-R2) in human prostate cancer

1997 • 191 citations

Fibroblast Growth Factor-10

1999 • 189 citations

Vascular Endothelial Growth Factor (VEGF) Expression in Prostate Cancer and Benign Prostatic Hyperplasia

1997 • 185 citations

Basic fibroblast growth factor in human prostate cancer cells.

1992 • 184 citations

Endogenous interleukin 6 is a resistance factor for cis-diamminedichloroplatinum and etoposide-mediated cytotoxicity of human prostate carcinoma cell lines.

1995 • 173 citations

Autonomous growth of androgen-independent human prostatic carcinoma cells: role of transforming growth factor alpha.

1991 • 170 citations

Prostatic Epidermal Growth Factor Receptors and Their Regulation by Androgens*

1987 • 167 citations

Expression of p160erbB-3 and p185erbB-2 in Prostatic Intraepithelial Neoplasia and Prostatic Adenocarcinoma

1994 • 162 citations

Protein and messenger ribonucleic acid (mRNA) for the type 1 insulin-like growth factor (IGF) receptor is decreased and IGF-II mRNA is increased in human prostate carcinoma compared to benign prostate epithelium.

1996 • 162 citations

NEUTRALIZING ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR ANTIBODY INHIBITS FURTHER GROWTH OF ESTABLISHED PROSTATE CANCER AND METASTASES IN A PRE-CLINICAL MODEL

1999 • 160 citations

Epidermal growth factor (EGF) receptor blockade inhibits the action of EGF, insulin-like growth factor I, and a protein kinase A activator on the mitogen-activated protein kinase pathway in prostate cancer cell lines.

1999 • 159 citations

Expression of the interleukin 6 receptor and interleukin 6 in prostate carcinoma cells.

1990 • 154 citations

Growth regulation of human prostate cancer cells by bone morphogenetic protein-2.

1997 • 153 citations

TGFβ in prostate cancer: A growth inhibitor that can enhance tumorigenicity

1997 • 150 citations

Expression of bone morphogenetic protein messenger RNAs by normal rat and human prostate and prostate cancer cells

1994 • 149 citations

Expression of bone morphogenetic proteins in human prostatic adenocarcinoma and benign prostatic hyperplasia

1992 • 143 citations

Restoration of transforming growth factor beta signaling pathway in human prostate cancer cells suppresses tumorigenicity via induction of caspase-1-mediated apoptosis.

1999 • 143 citations

Prognostic significance of HER-2/neu gene amplification status by fluorescence in Situ hybridization of prostate carcinoma

1997 • 141 citations

Regulation of growth by a nerve growth factor-like protein which modulates paracrine interactions between a neoplastic epithelial cell line and stromal cells of the human prostate.

1991 • 141 citations

Insulin-like growth factor-binding protein-2 in patients with prostate carcinoma and benign prostatic hyperplasia.

1997 • 135 citations

Down-regulation of protein and mRNA expression for transforming growth factor-β (TGF-β1) type I and type II receptors in human prostate cancer

1997 • 130 citations

Interleukin 10 (IL-10) inhibition of primary human prostate cell-induced angiogenesis: IL-10 stimulation of tissue inhibitor of metalloproteinase-1 and inhibition of matrix metalloproteinase (MMP)-2/MMP-9 secretion.

1999 • 130 citations

High frequency of fibroblast growth factor (FGF) 8 expression in clinical prostate cancers and breast tissues, immunohistochemically demonstrated by a newly established neutralizing monoclonal antibody against FGF 8.

1998 • 124 citations

Bone morphogenetic protein 6 in skeletal metastases from prostate cancer and other common human malignancies

1998 • 124 citations

Immunohistochemistry analysis of platelet-derived growth factor A and B chains and platelet-derived growth factor alpha and beta receptor expression in benign prostatic hyperplasias and Gleason-graded human prostate adenocarcinomas.

1994 • 122 citations

Production of epidermal growth factor and transforming growth factor‐α by the androgen‐responsive LNCaP human prostate cancer cell line

1990 • 122 citations

Insulin‐Like Growth Factor (IGF) System Components in Human Prostatic Cancer Cell‐Lines: LNCaP, DU145, and PC‐3 Cells

1996 • 121 citations

Immunolocalization and messenger RNA expression of bone morphogenetic protein-6 in human benign and malignant prostatic tissue.

1997 • 118 citations

Reduced expression of the low affinity nerve growth factor receptor in benign and malignant human prostate tissue and loss of expression in four human metastatic prostate tumor cell lines.

1992 • 117 citations

Highly metastatic human prostate cancer growing within the prostate of athymic mice overexpresses vascular endothelial growth factor.

1999 • 115 citations

Expression of Fibroblast Growth Factors (FGFs) and FGF Receptors in Human Prostate

1997 • 114 citations

Prostate: Basic And Clinical Aspects

1997 • 114 citations

Cell cycle-independent death of prostate adenocarcinoma is induced by the trk tyrosine kinase inhibitor CEP-751 (KT6587).

1998 • 114 citations

In vitro invasiveness of DU-145 human prostate carcinoma cells is modulated by EGF receptor-mediated signals

1995 • 111 citations

Expression of Nerve Growth Factor and Nerve Growth Factor Receptor Genes in Human Tissues and in Prostatic Adenocarcinoma Cell Lines

1992 • 111 citations

Insulin-like growth factor axis abnormalities in prostatic stromal cells from patients with benign prostatic hyperplasia.

1994 • 103 citations

Potentiation of the antiangiogenic ability of linomide by androgen ablation involves down-regulation of vascular endothelial growth factor in human androgen-responsive prostatic cancers.

1997 • 102 citations

HER-2/neu gene amplification status in prostate cancer by fluorescence in situ hybridization

1997 • 102 citations

Interleukin-6 Induces G1Arrest through Induction of p27Kip1, a Cyclin-Dependent Kinase Inhibitor, and Neuron-like Morphology in LNCaP Prostate Tumor Cells

1999 • 102 citations

Expression of c‐erb B‐2/neu proto‐oncogene in human prostatic cancer tissues and cell lines

1992 • 101 citations

Bcl-2 Suppresses Apoptosis Resulting from Disruption of the NF-κB Survival Pathway☆

1997 • 101 citations

Stromal cells from human benign prostate hyperplasia produce a growth-inhibitory factor for LNCaP prostate cancer cells, identified as interleukin-6

1996 • 98 citations

Analysis of growth factor and receptor mRNA levels during development of the rat seminal vesicle and prostate

1997 • 98 citations

Distribution of Nerve Growth Factor-Like Protein and Nerve Growth Factor Receptor in Human Benign Prostatic Hyperplasia and Prostatic Adenocarcinoma

1992 • 97 citations

Expression of a Trk high affinity nerve growth factor receptor in the human prostate.

1995 • 96 citations

Human prostate cancer model: Roles of growth factors and extracellular matrices

1992 • 95 citations

The Effects of Growth Factors Associated with Osteoblasts on Prostate Carcinoma Proliferation and Chemotaxis: Implications for the Development of Metastatic Disease*

1997 • 95 citations

Insulin‐like growth factor‐binding protein‐2 in patients with prostate carcinoma and benign prostatic hyperplasia

1997 • 95 citations

Basic fibroblast growth factor levels in cancer cells and in sera of patients suffering from proliferative disorders of the prostate

1997 • 93 citations

Interleukin 6 Receptor mRNA in Prostate Carcinomas and Benign Prostate Hyperplasia

1994 • 92 citations

Molecular characterization of neurotrophin expression and the corresponding tropomyosin receptor kinases (trks) in epithelial and stromal cells of the human prostate

1997 • 90 citations

Overexpression of an Inhibitory Insulin-Like Growth Factor Binding Protein (IGFBP), IGFBP-4, Delays Onset of Prostate Tumor Formation¹

1998 • 90 citations

Regulation of fibroblast hepatocyte growth factor/scatter factor expression by human breast carcinoma cell lines and peptide growth factors.

1993 • 89 citations

Effect of epidermal growth factor on prostate cancer cell line PC3 growth and invasion

1994 • 88 citations

Binding of epidermal growth factor by human normal, hypertrophic, and carcinomatous prostate

1989 • 86 citations

Keratinocyte growth factor expression in hormone insensitive prostate cancer

1997 • 85 citations

Secretion of epidermal growth factor and related polypeptides by the DU 145 human prostate cancer cell line

1989 • 82 citations

Platelet-derived growth factor A and B chains and the α and β receptors in prostatic intraepithelial neoplasia

1996 • 81 citations

Blocking signaling through the gp130 receptor chain by interleukin-6 and oncostatin M inhibits PC-3 cell growth and sensitizes the tumor cells to etoposide and cisplatin-mediated cytotoxicity

1999 • 80 citations

Expression of basic fibroblast growth factor mRNA in benign prostatic hyperplasia and prostatic carcinoma

1988 • 80 citations

Epidermal growth factor receptor monoclonal antibody inhibits constitutive receptor phosphorylation, reduces autonomous growth, and sensitizes androgen-independent prostatic carcinoma cells to tumor necrosis factor alpha.

1992 • 80 citations

Activin inhibits basal and androgen-stimulated proliferation and induces apoptosis in the human prostatic cancer cell line, LNCaP.

1996 • 78 citations

Platelet‐derived growth factor induces proliferation of hyperplastic human prostatic stromal cells

1993 • 76 citations

Expression and Localization of Activin Subunits and Follistatins in Tissues from Men with High Grade Prostate Cancer

1997 • 75 citations

Bone morphogenetic protein-6 expression in normal and malignant prostate

1995 • 70 citations

The Effects of Basic Fibroblast Growth Factor and suramin on Cell Motility and Growth of Rat Prostate Cancer Cells

1991 • 70 citations

Growth inhibitory response to activin A and B by human prostate tumour cell lines, LNCaP and DU145

1997 • 68 citations

Molecular cloning and characterization of human FGF8 alternative messenger RNA forms.

1996 • 67 citations

Over-expression of fibroblast growth factor-8 in human prostate cancer.

1996 • 67 citations

Regulation of prostate growth by fibroblast growth factors

1995 • 65 citations

Expression of p75NTR in a human prostate epithelial tumor cell line reduces nerve growth factor–induced cell growth by activation of programmed cell death

1998 • 63 citations

Response of prostate cancer cells to peptide growth factors: transforming growth factor-beta.

1991 • 62 citations

Regulation of DUI45 human prostate cancer cell proliferation by insulin‐like growth factors and its interaction with the epidermal growth factor autocrine loop

1994 • 61 citations

Transforming growth factor beta as a clinical biomarker for prostate cancer

1997 • 60 citations

Human androgen‐induced growth factor in prostate and breast cancer cells: its molecular cloning and growth properties

1995 • 58 citations

Epidermal growth factor (EGF) promotes chemomigration of a human prostate tumor cell line, and EGF immunoreactive proteins are present at sites of metastasis in the stroma of lymph nodes and medullary bone

1996 • 58 citations

Activin inhibition of prostate cancer cell growth: selective actions on androgen-responsive LNCaP cells.

1996 • 58 citations

7S nerve growth factor is an insulin-like growth factor-binding protein protease.

1996 • 56 citations

Expression of multiple angiogenic cytokines in cultured normal human prostate epithelial cells: Predominance of vascular endothelial growth factor

1999 • 55 citations

Relationship Between Serum Levels of Interleukin-6, Tumor Necrosis Factor-.ALPHA. and Bone Turnover Markers in Prostate Cancer Patients.

1998 • 55 citations

Characteristics of FGF-receptors Expressed by Stromal and Epithelial Cells Cultured from Normal and Hyperplastic Prostates

1994 • 54 citations

Biomarker Expression in Prostatic Intraepithelial Neoplasia

1996 • 54 citations

Immunohistochemical localization of TGFβ1, TGFβ2, and TGFβ3 in normal and malignant human prostate

1997 • 53 citations

Cloning of human bone morphogenetic protein type IB receptor (BMPR-IB) and its expression in prostate cancer in comparison with other BMPRs

1997 • 52 citations

Inhibins, activins, and follistatins: Expression of mRNAs and cellular localization in tissues from men with benign prostatic hyperplasia

1998 • 51 citations

Regulation of lnvasive Potential of Human Prostate Cancer Cell Lines by Hepatocyte Growth Factor

1998 • 51 citations

Keratinocyte Growth Factor and Receptor mRNA Expression in Benign and Malignant Human Prostate

1995 • 50 citations

Comparative analysis of epidermal growth factor receptor gene expression and protein product in benign, premalignant, and malignant prostate tissue

1994 • 49 citations

Loss of low-affinity nerve growth factor receptor during malignant transformation of the human prostate

1997 • 49 citations

Characterization of nerve growth factor precursor protein expression by human prostate stromal cells: A role in selective neurotrophin stimulation of prostate epithelial cell growth

1999 • 47 citations

Heparin-binding EGF-like growth factor in the human prostate: Synthesis predominantly by interstitial and vascular smooth muscle cells and action as a carcinoma cell mitogen

1998 • 45 citations

Oncogene amplifications in early‐stage human prostate carcinomas

1994 • 43 citations

Insulin-like growth factor-I (IGF-I) and its binding protein IGFBP-4 in human prostatic hyperplastic tissue: gene expression and its cellular localization.

1994 • 40 citations

Expression of fibroblast growth factor-8 in adult rat tissues and human prostate carcinoma cells

1996 • 40 citations

TNF-mediated cytotoxicity and resistance in human prostate cancer cell lines

1996 • 40 citations

Mutational analysis of the TrkA gene in prostate cancer

1998 • 39 citations

Inhibition of chemomigration of a human prostatic carcinoma cell (TSU-pr1) line by inhibition of epidermal growth factor receptor function

1996 • 36 citations

Effect of tumor necrosis factor-? and interferon-? on the growth of human prostate cancer cell lines

1995 • 36 citations

Mechanisms of the Suppression of the Bladder Activity by Flavoxate

1996 • 35 citations

Expression of transforming growth factor beta 1 TGFβ1), -β2, and -β3 by cultured human prostate cells

1996 • 34 citations

The expression and localisation of beta-nerve growth factor (beta-NGF) in benign and malignant human prostate tissue: relationship to neuroendocrine differentiation

1996 • 33 citations

Cytokine regulation of the matrix metalloproteinases and their inhibitors in human papillomavirus-18 transformed human prostatic tumor cell lines.

1996 • 32 citations

Co-expression of hepatocyte growth factor and its receptor in human prostate cancer.

1998 • 30 citations

IDENTIFICATION OF AN ACTIVIN-FOLLISTATIN GROWTH MODULATORY SYSTEM IN THE HUMAN PROSTATE: SECRETION AND BIOLOGICAL ACTIVITY IN PRIMARY CULTURES OF PROSTATIC EPITHELIAL CELLS

1999 • 29 citations

Anti‐Proliferative Effect of the Kinase Inhibitor K252a on Human Prostatic Carcinoma Cell Lines

1996 • 29 citations

Metastasis induced by overexpression of p185neu-T after orthotopic injection into a prostatic epithelial cell line (NbE)

1997 • 27 citations

Expression and localization of inhibin/activin subunits and activin receptors in the normal rat prostate

1997 • 25 citations

Neuroendocrine cells of the verumontanum: a comparative immunohistochemical study

1998 • 25 citations

Density‐dependent regulation of epidermal growth factor receptor expression in DU 145 human prostate cancer cells

1991 • 24 citations

Insulin-like growth factor-binding protein-3 expression and secretion by cultures of human prostate epithelial cells and stromal fibroblasts

1994 • 24 citations

Platelet-derived growth factor (PDGF)-signaling mediates radiation-induced apoptosis in human prostate cancer cells with loss of p53 function

1997 • 22 citations

Comparative studies of the mitogenic effects of epidermal growth factor and transforming growth factor-α and the expression of various growth factors in neoplastic and non-neoplastic prostatic cell lines

1997 • 21 citations

Enhancement of prostate cancer xenograft growth with whole-body radiation and vascular endothelial growth factor.

1997 • 21 citations

Differential immunoreactivity of transforming growth factor alpha in benign, dysplastic and malignant prostatic tissues

1994 • 19 citations

NGF-ß, NE-Cells and Prostatic Cancer Cell Lines: A Study of Neuroendocrine Expression in the Human Prostatic Cancer Cell Lines DU-145, PC-3, LNCaP, and TSU-pr1 Following Stimulation of the Nerve Growth Factor-ß

1998 • 18 citations

Enlargement of the ampullary gland and seminal vesicle, but not the prostate in int-2/Fgf-3 transgenic mice

1998 • 17 citations

EXPRESSION OF ACTIVIN AND ACTIVIN RECEPTORS IN HUMAN PROSTATIC-CARCINOMA CELL-LINE DU145

1995 • 17 citations

Analysis of Bone Mineral Density and Polymorphism of Estrogen Receptor Gene in Patients with Precocious Puberty

1998 • 11 citations

Role of the low‐affinity nerve growth factor receptor and the high‐affinity trk nerve growth factor receptor in human prostate carcinogenesis

1995 • 10 citations

Editorial

1996 • 2 citations