Regulation of prostate growth by fibroblast growth factors

Transforming growth factor beta

2011 • 1,990 citations

THE HEPARIN-BINDING (FIBROBLAST) GROWTH FACTOR FAMILY OF PROTEINS

1989 • 1,948 citations

Structural and Functional Diversity in the FGf Receptor Multigene Family

1992 • 1,262 citations

Human KGF is FGF-Related with Properties of a Paracrine Effector of Epithelial Cell Growth

1989 • 989 citations

Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia

1994 • 903 citations

Purification and characterization of a newly identified growth factor specific for epithelial cells.

1989 • 842 citations

Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene.

1992 • 760 citations

Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors.

1990 • 635 citations

Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells.

1992 • 634 citations

Fibroblast growth factor receptor tyrosine kinases: molecular analysis and signal transduction

1992 • 625 citations

The Function of KGF in Morphogenesis of Epithelium and Reepithelialization of Wounds

1994 • 597 citations

Activating and inhibitory heparin sequences for FGF-2 (basic FGF). Distinct requirements for FGF-1, FGF-2, and FGF-4.

1993 • 542 citations

Complexity of FGF receptors: genetic basis for structural diversity and functional specificity

1992 • 441 citations

Expression of Transforming Growth Factor-β in the Rat Ventral Prostate during Castration-Induced Programmed Cell Death

1989 • 417 citations

Fibroblast growth factors are present in the extracellular matrix produced by endothelial cells invitro: Implications for a role of heparinase-like enzymes in the neovascular response

1987 • 416 citations

Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy.

1993 • 408 citations

Cloning and characterization of an androgen-induced growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells.

1992 • 404 citations

Molecular Cloning of a Novel Cytokine cDNA Encoding the Ninth Member of the Fibroblast Growth Factor Family, which has a Unique Secretion Property

1993 • 390 citations

The fibroblast growth factor family: Structural and biological properties

1989 • 362 citations

The Effect of Nafarelin Acetate, a Luteinizing-Hormone–Releasing Hormone Agonist, on Benign Prostatic Hyperplasia

1987 • 334 citations

Differential Splicing in the Extracellular Region of Fibroblast Growth Factor Receptor 1 Generates Receptor Variants with Different Ligand-Binding Specificities

1992 • 321 citations

Direct mitogenic effects of insulin, epidermal growth factor, glucocorticoid, cholera toxin, unknown pituitary factors and possibly prolactin, but not androgen, on normal rat prostate epithelial cells in serum-free, primary cell culture.

1984 • 315 citations

Light Microscopic Stereological Analysis of the Normal Human Prostate and of Benign Prostatic Hyperplasia

1979 • 306 citations

Fibroblast growth factor receptor (FGFR) 3. Alternative splicing in immunoglobulin-like domain III creates a receptor highly specific for acidic FGF/FGF-1

1994 • 301 citations

The Relative Proportion of Stromal and Epithelial Hyperplasia is Related to the Development of Symptomatic Benign Prostate Hyperplasia

1992 • 291 citations

Heparin-binding keratinocyte growth factor is a candidate stromal-to-epithelial-cell andromedin.

1992 • 287 citations

Extracellular sequestration and release of fibroblast growth factor: a regulatory mechanism?

1991 • 284 citations

A truncated form of fibroblast growth factor receptor 1 inhibits signal transduction by multiple types of fibroblast growth factor receptor.

1992 • 272 citations

Isolation of cDNAs encoding four mouse FGF family members and characterization of their expression patterns during embryogenesis

1990 • 266 citations

K-sam, an amplified gene in stomach cancer, is a member of the heparin-binding growth factor receptor genes.

1990 • 260 citations

Stromal-epithelial interactions—I. Induction of prostatic phenotype in urothelium of testicular feminized (Tfm/y) mice

1981 • 227 citations

Ligand-induced transphosphorylation between different FGF receptors.

1991 • 189 citations

Prostate and Bone Fibroblasts Induce Human Prostate Cancer Growth in Vivo: Implications for Bidirectional Tumor-Stromal Cell Interaction in Prostate Carcinoma Growth and Metastasis

1992 • 188 citations

Nuclear androgen receptors in the epithelium and stroma of human benign prostatic hypertrophic glands

1983 • 188 citations

Keratinocyte growth factor functions in epithelial induction during seminal vesicle development.

1994 • 187 citations

Basic fibroblast growth factor in human prostate cancer cells.

1992 • 184 citations

Increased expression of genes for basic fibroblast growth factor and transforming growth factor type β2 in human benign prostatic hyperplasia

1990 • 181 citations

Identification of a Cellular Receptor for Transforming Growth Factor-β in Rat Ventral Prostate and Its Negative Regulation by Androgens*

1988 • 178 citations

Modes of FGF release in vivo and in vitro

1990 • 169 citations

Role of peptide growth factors in the prostate: A review

1993 • 165 citations

Serum-free growth of adult human prostatic epithelial cells

1986 • 164 citations

Complete primary structure of prostatropin, a prostate epithelial cell growth factor

1986 • 163 citations

Fibroblast growth factor receptor-4 shows novel features in genomic structure, ligand binding and signal transduction.

1992 • 162 citations

Heparin Is Required for Cell-Free Binding of Basic Fibroblast Growth Factor to a Soluble Receptor and for Mitogenesis in Whole Cells

1992 • 160 citations

3 Fibroblast Growth Factor and Its Involvement in Developmental Processes

1990 • 148 citations

Nuclear signaling pathways for polypeptide ligands and their membrane receptors?

1994 • 133 citations

Exon Switching and Activation of Stromal and Embryonic Fibroblast Growth Factor (FGF)-FGF Receptor Genes in Prostate Epithelial Cells Accompany Stromal Independence and Malignancy

1993 • 131 citations

Heparin-binding growth factor gene expression and receptor characteristics in normal rat prostate and two transplantable rat prostate tumors.

1989 • 127 citations

Fibroblast growth factor enhances type beta 1 transforming growth factor gene expression in osteoblast-like cells.

1989 • 125 citations

Growth factors and their receptors as determinants in the proliferation and metastasis of human prostate cancer

1993 • 123 citations

Basic fibroblast growth factor: a potential mediator of stromal growth in the human prostate.

1992 • 118 citations

Growth factors and oncogenes in prostate cancer.

1990 • 115 citations

Anatomy of the prostate and morphogenesis of BPH.

1984 • 111 citations

Prostatic growth factor: purification and structural relationship to basic fibroblast growth factor

1987 • 105 citations

Cultured human prostate‐derived fibroblasts produce a factor that stimulates their growth with properties indistinguishable from basic fibroblast growth factor

1989 • 101 citations

Reciprocal mesenchymal-epithelial interaction affecting prostate tumour growth and hormonal responsiveness.

1991 • 97 citations

Direct effect of basic fibroblast growth factor on gene transcription in a cell-free system.

1992 • 97 citations

Human prostate cancer model: Roles of growth factors and extracellular matrices

1992 • 95 citations

Prostatic osteoblastic factor.

1979 • 86 citations

Distinct Role of 2-O-, N-, and 6-O-Sulfate Groups of Heparin in the Formation of the Ternary Complex with Basic Fibroblast Growth Factor and Soluble FGF Receptor-1

1994 • 85 citations

Influence of transforming growth factor β1 and other growth factors on basic fibroblast growth factor level and proliferation of cultured human prostate‐derived fibroblasts

1993 • 74 citations

Gene activity during the early phase of androgen-stimulated rat prostate regrowth.

1989 • 72 citations

Benign Prostatic Hyperplasia Treated by Castration or the LH-RH Analogue Buserelin: A Report on 6 Cases

1986 • 71 citations

Amino-terminal sequence of a large form of basic fibroblast growth factor isolated from human benign prostatic hyperplastic tissue

1987 • 69 citations

Characterization of Growth Factors Derived from the Rat Ventral Prostate

1988 • 67 citations

Polypeptide modulators of prostatic growth and development.

1991 • 63 citations

Characteristics of FGF-receptors Expressed by Stromal and Epithelial Cells Cultured from Normal and Hyperplastic Prostates

1994 • 54 citations

Implications of stromal-epithelial interaction in human prostate cancer growth, progression and differentiation.

1993 • 53 citations

Heparin‐binding growth factor isolated from human prostatic extracts

1988 • 53 citations

Effect of Long-Acting Gonadotropin-Releasing Hormone Analog (Leuprolide) Therapy on Prostatic Size and Symptoms in 15 Men with Benign Prostatic Hypertrophy

1989 • 53 citations

Activation of fibroblast growth factor (FGF) receptors by recombinant human FGF-5.

1993 • 52 citations

Androgenic effects upon prostatic epithelium are mediated via trophic influences from stroma.

1984 • 49 citations

Investigative Urology: Regional Concentration of Basic Fibroblast Growth Factor in Normal and Benign Hyperplastic Human Prostates

1995 • 48 citations

Comparative analysis of growth factors in normal and pathologic human prostates

1988 • 47 citations

Growth factor receptors and prostate cell growth.

1991 • 45 citations

II. Stromal and Epithelial Cells from Rat Ventral Prostate during Androgen Deprivation and Estrogen Treatment — Regulation of Transcription

2009 • 43 citations

Regulation of basic fibroblast growth factor expression by transforming growth factor beta in cultured human prostate stromal cells

1996 • 39 citations

Dominant-negative mutations of platelet-derived growth factor (PDGF) receptors. Inhibition of receptor function by ligand-dependent formation of heterodimers between PDGF alpha- and beta-receptors.

1993 • 39 citations

Cloning of two novel forms of human acidic fibroblast growth factor (aFGF) mRNA

1993 • 38 citations

Regulation of differentiation and growth of normal adult and neoplastic epithelia by inductive mesenchyme.

1991 • 35 citations

Biology of the fibroblast growth factor gene family.

1990 • 33 citations

5α‐reductase activity in epithelium and stroma of prostates from intact and castrated dogs treated with androstenedione, the aromatase inhibitor 1‐methyl‐1,4‐androstadiene‐3, 17‐dione, and cyproterone acetate

1988 • 29 citations

Interaction of androgen-induced autocrine heparin-binding growth factor with fibroblast growth factor receptor on androgen-dependent Shionogi carcinoma 115 cells.

1990 • 29 citations

Androgen receptor localization in the human prostate: Demonstration of heterogeneity using a new method of steroid receptor autoradiography

1987 • 22 citations

In vivo and in vitro effects of androgen on fibroblast growth factor‐2 concentrations in the human prostate

1994 • 16 citations

Heparin inhibits autocrine stimulation but not fibroblast growth factor stimulation of cell proliferation of androgen‐responsive shionogi carcinoma 115

1991 • 15 citations

Acidic fibroblast growth factor gene 5′ non‐coding exon and flanking region from hamster DDT1 cells: Identification of the promoter region and transcriptional regulation by testosterone and aFGF protein

1993 • 14 citations

Rat prostate cancer cell line-specific production and apparent secretion of heparin-binding growth factors.

1992 • 12 citations

Positive and negative modulators of prostate cell proliferation

1994 • 12 citations

Heparin-Binding (Fibroblast) Growth Factor/Receptor Gene Expression in the Prostate

1991 • 9 citations

A role for heparan sulfate in androgen-induced deoxyribonucleic acid synthesis of mouse mammary carcinoma (Shionogi carcinoma 115)-derived SC-3 cells.

1993 • 8 citations

Heparin-Binding Fibroblast Growth Factors and Prostate Cancer

1993 • 8 citations

Mapping of a Transcription Element Critical for Expression of the Fibroblast Growth Factor Receptor 1 Gene

1994 • 7 citations

Fibroblast Growth Factor: Implications in the Etiology of Benign Prostatic Hyperplasia

1991 • 6 citations

Molecular genetic detection of Xp21 muscular dystrophy carriers in Cyprus

1994 • 4 citations