Cloning and Characterization of a Family of Proteins Associated with Mpl

Heterotrimeric C proteins: Organizers of transmembrane signals

1995 • 1,388 citations

Interaction of 14-3-3 with Signaling Proteins Is Mediated by the Recognition of Phosphoserine

1996 • 1,371 citations

Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2

1996 • 1,081 citations

Toward a functional analysis of the yeast genome through exhaustive two-hybrid screens

1997 • 886 citations

Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats

1996 • 824 citations

Identification of the spinocerebellar ataxia type 2 gene using a direct identification of repeat expansion and cloning technique, DIRECT

1996 • 745 citations

Arginine Methylation of STAT1 Modulates IFNα/β-Induced Transcription

2001 • 475 citations

A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors

1990 • 404 citations

Peptide Agonist of the Thrombopoietin Receptor as Potent as the Natural Cytokine

1997 • 400 citations

Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin

1998 • 389 citations

Role of c-mpl in Early Hematopoiesis

1998 • 362 citations

The c-Mpl Ligand (Thrombopoietin) Stimulates Tyrosine Phosphorylation of Jak2, Shc, and c-Mpl

1995 • 235 citations

Thrombopoietin activates a STAT5-like factor in hematopoietic cells.

1995 • 218 citations

A novel protein with RNA-binding motifs interacts with ataxin-2

2000 • 218 citations

Thrombopoietin-Induced Activation of the Mitogen-Activated Protein Kinase (MAPK) Pathway in Normal Megakaryocytes: Role in Endomitosis

1999 • 212 citations

Tob, a novel protein that interacts with p185erbB2, is associated with anti-proliferative activity.

1996 • 190 citations

A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor

1997 • 179 citations

A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40

1995 • 177 citations

Dissecting the thrombopoietin receptor: Functional elements of the Mpl cytoplasmic domain

1997 • 158 citations

Control of Thrombopoietin-Induced Megakaryocytic Differentiation by the Mitogen-Activated Protein Kinase Pathway

1997 • 152 citations

Normal Platelets and Megakaryocytes Are Produced In Vivo in the Absence of Thrombopoietin

1997 • 132 citations

Neuronal intranuclear inclusions in spinocerebellar ataxia type 2: triple-labeling immunofluorescent study

1999 • 126 citations

Thrombopoietin Signal Transduction Requires Functional JAK2, Not TYK2

1999 • 121 citations

Thrombopoietin Induces Phosphoinositol 3-Kinase Activation through SHP2, Gab, and Insulin Receptor Substrate Proteins in BAF3 Cells and Primary Murine Megakaryocytes

2001 • 119 citations

Cytokine-Specific Transcriptional Regulation Through an IL-5Rα Interacting Protein

2001 • 117 citations

Thrombopoietin: the Primary Regulator of Megakaryocyte and Platelet Production

1995 • 114 citations

Thrombopoietin-Mediated Sustained Activation of Extracellular Signal-Regulated Kinase in UT7-Mpl Cells Requires Both Ras–Raf-1- and Rap1–B-Raf-Dependent Pathways

2001 • 97 citations

Functional Regions of the Mouse Thrombopoietin Receptor Cytoplasmic Domain: Evidence for a Critical Region Which Is Involved in Differentiation and Can Be Complemented by Erythropoietin

1996 • 93 citations

Association of RACK1 and PKCβ with the common β-chain of the IL-5/IL-3/GM-CSF receptor

1999 • 83 citations

Megakaryocyte Growth and Development Factor-Induced Proliferation and Differentiation Are Regulated by the Mitogen-Activated Protein Kinase Pathway in Primitive Cord Blood Hematopoietic Progenitors

1999 • 82 citations

The expansion of the CAG repeat in ataxin-2 is a frequent cause of autosomal dominant spinocerebellar ataxia

1997 • 74 citations

Detection of single-copy genes by nonisotopic in situ hybridization on human chromosomes

1989 • 72 citations

Role of the Distal Half of the c-Mpl Intracellular Domain in Control of Platelet Production by Thrombopoietin In Vivo

2000 • 51 citations

Genomic Structure of the Human Gene for Spinocerebellar Ataxia Type 2 (SCA2) on Chromosome 12q24.1

1998 • 49 citations

Thrombopoietin and Thrombin Induce Tyrosine Phosphorylation of Vav in Human Blood Platelets

1997 • 49 citations

Role of Gab proteins in phosphatidylinositol 3-kinase activation by thrombopoietin (Tpo)

2001 • 44 citations

Thrombopoietin induces activation of the phosphatidylinositol-3′ kinase pathway and formation of a complex containing p85PI3K and the protooncoprotein p120CBL

1997 • 39 citations

Thrombopoietin: More than a lineage‐specific megakaryocyte growth factor

1997 • 30 citations

Characterization of mpl cytoplasmic domain sequences required for myeloproliferative leukemia virus pathogenicity

1994 • 30 citations

A Thrombopoietin Receptor Mutant Deficient in Jak-STAT Activation Mediates Proliferation But Not Differentiation in UT-7 Cells

1999 • 30 citations

The yeast two-hybrid screening technique and its use in the study of protein-protein interactions in apoptosis

1998 • 29 citations

A Structure-Function Analysis of Serine/Threonine Phosphorylation of the Thrombopoietin Receptor, c-Mpl

2000 • 26 citations

Thrombopoietin and its receptor.

1998 • 21 citations

Constitutive activation of a variant of the env-mpl oncogene product by disulfide-linked homodimerization

1995 • 18 citations

Characterization of Mpl mutants using primary megakaryocyte-lineage cells from mpl-/- mice: a new system for Mpl structure-function studies

2001 • 17 citations

Coupling of Heterotrimeric Gi Proteins to the Erythropoietin Receptor

2001 • 17 citations

Identification of the Physiological Promoter for Spinocerebellar Ataxia 2 Gene Reveals a CpG Island for Promoter Activity Situated into the Exon 1 of This Gene and Provides Data about the Origin of the Nonmethylated State of These Types of Islands

1999 • 15 citations

Trinucleotide repeats and hereditary ataxias

1997 • 3 citations