The yeast two-hybrid screening technique and its use in the study of protein-protein interactions in apoptosis

A novel genetic system to detect protein–protein interactions

1989 • 6,022 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

Caspases: killer proteases

1997 • 2,440 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.

1995 • 2,142 citations

The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation

1995 • 1,979 citations

Double identity for proteins of the Bcl-2 family

1997 • 1,511 citations

GAL4-VP16 is an unusually potent transcriptional activator

1988 • 1,379 citations

MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1

1997 • 1,294 citations

The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

1995 • 1,237 citations

Identification and Characterization of an IκB Kinase

1997 • 1,166 citations

A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain

1995 • 1,007 citations

RIP: A novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death

1995 • 964 citations

Site-Specific Phosphorylation of IκBα by a Novel Ubiquitination-Dependent Protein Kinase Activity

1996 • 960 citations

Daxx, a Novel Fas-Binding Protein That Activates JNK and Apoptosis

1997 • 797 citations

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.

1996 • 731 citations

FAP-1: A Protein Tyrosine Phosphatase That Associates with Fas

1995 • 702 citations

Caspases and caspase inhibitors

1997 • 573 citations

RAIDD is a new 'death' adaptor molecule

1997 • 547 citations

The CARD domain: a new apoptotic signalling motif

1997 • 532 citations

NF-κB Activation: The IκB Kinase Revealed?

1997 • 492 citations

The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein.

1990 • 417 citations

The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex

1996 • 415 citations

The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation.

1996 • 414 citations

Programmed cell death in Caenorhabditis elegans

1994 • 379 citations

Proteasomes: destruction as a programme

1996 • 373 citations

Interaction between the C. elegans cell-death regulators CED-9 and CED-4

1997 • 304 citations

CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein

1997 • 294 citations

TANK, a co-inducer with TRAF2 of TNF- and CD 40L-mediated NF-kappaB activation.

1996 • 283 citations

Fas-associated Death Domain Protein Interleukin-1β-converting Enzyme 2 (FLICE2), an ICE/Ced-3 Homologue, Is Proximally Involved in CD95- and p55-mediated Death Signaling

1997 • 256 citations

CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP.

1997 • 252 citations

New members of the Bcl-2 family and their protein partners

1996 • 248 citations

Cell death induction by TNF: a matter of self control

1997 • 231 citations

I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction.

1996 • 210 citations

TRAF-interacting Protein (TRIP): A Novel Component of the Tumor Necrosis Factor Receptor (TNFR)- and CD30-TRAF Signaling Complexes That Inhibits TRAF2-mediated NF-κB Activation

1997 • 196 citations

[27] Gene identification using the yeast two-hybrid system

1996 • 195 citations

MADD, a Novel Death Domain Protein That Interacts with the Type 1 Tumor Necrosis Factor Receptor and Activates Mitogen-activated Protein Kinase

1997 • 164 citations

Interaction of Insulin Receptor Substrate-2 (IRS-2) with the Insulin and Insulin-like Growth Factor I Receptors

1996 • 133 citations

Interaction and Regulation of the Caenorhabditis elegans Death Protease CED-3 by CED-4 and CED-9

1997 • 130 citations

Stat5 is a physiological substrate of the insulin receptor

1997 • 122 citations

A Conditionally Expressed Third Partner Stabilizes or Prevents the Formation of a Transcriptional Activator in a Three-hybrid System

1997 • 120 citations

Interaction of PKN with α-Actinin

1997 • 117 citations

Direct physical interaction between the Caenorhabditis elegans ‘death proteins’ CED‐3 and CED‐4

1997 • 83 citations

Gene identification using the yeast two-hybrid system

1997 • 79 citations

A Yeast Three-Hybrid Method to Clone Ternary Protein Complex Components

1996 • 76 citations

Tag games in yeast: the two-hybrid system and beyond

1997 • 61 citations

Alternative Yeast Two-Hybrid Systems: The Interaction Trap and Interaction Mating

2003 • 49 citations

Functional Characterization of the Prodomain of Interleukin1β-converting Enzyme

1996 • 41 citations

Yeast GAL4 Two-Hybrid System: A Genetic System to Identify Proteins That interact with a Target Protein

2003 • 23 citations