Comparative properties of arginases
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Abstract
References (258)
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Arginase Induction by Suppressors of Nitric Oxide Synthesis (IL-4, IL-10 and PGE2) in Murine Bone-Marrow-Derived Macrophages
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Activated macrophages kill tumour cells by releasing arginase
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Inducible nitric oxide synthase from a rat alveolar macrophage cell line is inhibited by nitric oxide.
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Transport of Ornithine and Citrulline across the Mitochondrial Membrane
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Compartmental and regulatory mechanisms in the arginine pathways of Neurospora crassa and Saccharomyces cerevisiae
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Coinduction of nitric oxide synthase and argininosuccinate synthetase in a murine macrophage cell line. Implications for regulation of nitric oxide production.
1994 • 216 citations
Co-induction of Arginase and Nitric Oxide Synthase in Murine Macrophages Activated by Lipopolysaccharide
1995 • 213 citations
Renal arginine synthesis: studies in vitro and in vivo.
1990 • 211 citations
Calmodulin-independent nitric oxide synthase from rat polymorphonuclear neutrophils
1991 • 195 citations
Identification of a low affinity, high capacity transporter of cationic amino acids in mouse liver.
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Inducible cytosolic enzyme activity for the production of nitrogen oxides from L-arginine in hepatocytes
1990 • 179 citations
Inhibition of Rat Liver Arginase by an Intermediate in NO Biosynthesis, NG-Hydroxy-L-arginine: Implications for the Regulation of Nitric Oxide Biosynthesis by Arginase
1994 • 174 citations
Enzymes of Arginine and Urea Systhesis
1973 • 170 citations
Nω-Hydroxy-L-Arginine, an Intermediate in the L-Arginine to Nitric Oxide Pathway, Is a Strong Inhibitor of Liver and Macrophage Arginase
1994 • 170 citations
Rat Liver Arginase: Kinetic Mechanism, Alternate Substrates, and Inhibitors
1994 • 168 citations
The heterogeneity of arginases in rat tissues
1976 • 163 citations
Purification and properties of arginase of rat kidney
1973 • 163 citations
Role of Acetylglutamate in Ureotelism
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Free manganese(II) and iron(II) cations can act as intracellular cell controls
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Channeling of Urea Cycle Intermediates in Situ in Permeabilized Hepatocytes
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The urea cycle
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Molecular cloning and nucleotide sequence of cDNA for human liver arginase.
1987 • 142 citations
Ammonia Intoxication in the Near-Adult Cat as a Result of a Dietary Deficiency of Arginine
1978 • 130 citations
Short term regulation of ureagenesis.
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MAMMALIAN UREA CYCLE ENZYMES
1986 • 124 citations
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Über die Arginase.
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Ornithine-urea cycle enzymes in teleostean fish
1969 • 119 citations
Molecular Characteristics of Rat Liver Arginase
1968 • 117 citations
Arginine, an indispensable amino acid for patients with inborn errors of urea synthesis.
1984 • 115 citations
EPR evidence for binuclear manganese(II) centers in rat liver arginase
1992 • 113 citations
Expression of therocDEFOperon Involved in Arginine Catabolism inBacillus subtilis
1995 • 112 citations
Polyamine biogenesis in the rat mammary gland during pregnancy and lactation
1972 • 109 citations
Function of arginase in lactating mammary gland
1972 • 108 citations
Ubiquitous upstream repression sequences control activation of the inducible arginase gene in yeast.
1987 • 107 citations
Guanylyl Cyclase-Linked Receptors
1992 • 106 citations
Interaction between Arginase and <scp>l</scp>‐Ornithine Carbamoyltransferase in Saccharomyces cerevisiae
1974 • 105 citations
Hyperargininemia with Arginase Deficiency
1979 • 104 citations
Microenvironmental arginine depletion by macrophages in vivo
1979 • 99 citations
Subcellular Localization and Biochemical Properties of the Enzymes of Carbamoyl Phosphate and Urea Synthesis in the Batrachoidid Fishes Opsanus Beta, Opsanus Tau and Porichthys Notatus
1995 • 97 citations
Characteristics of arginases from ureotelic and non-ureotelic animals
1965 • 96 citations
Complete nucleotide sequence of cDNA and deduced amino acid sequence of rat liver arginase.
1987 • 95 citations
Elevated manganese concentration and arginase activity in livers of streptozotocin-induced diabetic rats.
1983 • 93 citations
Role of polyamines in macromolecular synthesis
1981 • 93 citations
Hereditary disorders of the urea cycle in man: Biochemical and molecular approaches
1987 • 92 citations
Hepatic role in pH regulation: role of the intercellular glutamine cycle
1984 • 90 citations
Differential cellular localization of enzymes ofl-arginine metabolism in the rat brain
1990 • 90 citations
Comparison of Substrate and Inhibitor Specificity of Arginase and Nitricm Oxide (NO) Synthase for Arginine Analogs and Related Compounds in Murine and Rat Macrophages
1994 • 90 citations
Nucleotide sequence of the Saccharomyces cerevisiae arginase gene (CAR1) and its transcription under various physiological conditions
1984 • 87 citations
Purification and properties of arginase from human liver and erythrocytes
1978 • 87 citations
Induction of urea cycle enzymes by glucagon and dexamethasone in monolayer cultures of adult rat hepatocytes.
1982 • 85 citations
Mutagenesis of Rat Liver Arginase Expressed in Escherichia coli: Role of Conserved Histidines
1994 • 82 citations
Isolation and characterization of
2014 • 82 citations
Immunologic Studies of Arginase in Tissues of Normal Human Adult and Arginase-Deficient Patients
1983 • 80 citations
Argininemia
1977 • 79 citations
Arginase Isozymes of Rat Mammary Gland, Liver, and Other Tissues
1973 • 78 citations
Isolation of human liver arginase cdna and demonstration of nonhomology between the two human arginase genes
1986 • 77 citations
Comparative physical-chemical studies of mammalian arginases
1970 • 76 citations
Developmental formation and distribution of arginase in rat tissues
1970 • 73 citations
Induced RAW 264.7 macrophages express soluble and particulate nitric oxide synthase: inhibition by transforming growth factor-ß
1992 • 72 citations
On the evolution of arginases and related enzymes
1994 • 71 citations
The gene for human liver arginase (ARG1) is assigned to chromosome band 6q23.
1986 • 71 citations
Carbamyl Phosphate Synthetase III, an Evolutionary Intermediate in the Transition Between Glutamine-dependent and Ammonia-dependent Carbamyl Phosphate Synthetases
1994 • 68 citations
Subcellular location of glutamine synthetase and urea cycle enzymes in liver of spiny dogfish (Squalus acanthias).
1982 • 66 citations
Hyperargininemia
1977 • 66 citations
Enzymatic mechanism of creatine amidinohydrolase as deduced from crystal structures
1990 • 64 citations
Early diagnosis of myocardial infarction by arginase activity determination
1975 • 64 citations
Human liver-type arginase gene: structure of the gene and analysis of the promoter region
1988 • 63 citations
Arginine metabolism in experimental glomerulonephritis: interaction between nitric oxide synthase and arginase
1994 • 61 citations
Coordinate Induction of the Urea Cycle Enzymes by Glucagon and Dexamethasone Is Accomplished by Three Different Mechanisms
1993 • 61 citations
Role of arginase in killing of schistosomula of schistosoma mansoni
1980 • 60 citations
Rabbit Liver l-Arginase
1972 • 58 citations
Biochemical properties of arginase in human adult and fetal tissues
1982 • 55 citations
STUDIES ON FUNCTIONAL AND METABOLIC ROLE OF UREA CYCLE INTERMEDIATES IN BRAIN
1976 • 55 citations
Arginase is a major pathway of L-arginine metabolism in nephritic glomeruli
1992 • 54 citations
INFLUENCE OF CATIONS ON THE INTRACELLULAR DISTRIBUTION OF RAT LIVER ARGINASE
1956 • 54 citations
Mitochondrial Arginase Activity from Cotyledons of Developing and Germinating Seeds of Vicia faba L
1975 • 53 citations
Functional Roles of Urea Synthesis in Vertebrates
1992 • 52 citations
Structural organization of the gene for rat liver-type arginase.
1988 • 52 citations
Characterisation of arginase from the extreme thermophile ‘Bacillus caldovelox’
1991 • 52 citations
Purification and Properties of Arginase from Soybean, Glycine max, Axes
1990 • 52 citations
Development of arginine-synthesizing enzymes in mouse intestine
1986 • 51 citations
Beef-Liver Arginase. Isolation and Molecular Properties
1972 • 51 citations
The purification and characterization of arginase from Saccharomyces cerevisiae.
1990 • 50 citations
Kinetic properties of erythrocyte- and liver arginase
1961 • 50 citations
Properties of fetal and adult red blood cell arginase: a possible prenatal diagnostic test for arginase deficiency.
1980 • 50 citations
Multiple positive and negative cis-acting elements mediate induced arginase (CAR1) gene expression in Saccharomyces cerevisiae.
1990 • 50 citations
Inducible L-Arginine-Dependent Nitric Oxide Synthase Activity in Bovine Bone Marrow-Derived Macrophages
1994 • 50 citations
pH-Sensitive control of arginase by Mn(II) ions at submicromolar concentrations
1991 • 49 citations
Purification and characterization of arginase from Neurospora crassa.
1987 • 49 citations
Dietary Manganese Deficiency Decreases Rat Hepatic Arginase Activity
1994 • 49 citations
Roles of metal ions in the maintenance of the tertiary and quaternary structure of arginase from Saccharomyces cerevisiae.
1991 • 48 citations
Control of Ornithine Carbamoyltransferase Activity by Arginase in Bacillus subtilis
1974 • 48 citations
Analysis and sequence of the speB gene encoding agmatine ureohydrolase, a putrescine biosynthetic enzyme in Escherichia coli
1990 • 48 citations
Effect of manganese on the quaternary structure of human liver arginase
1971 • 48 citations
Human arginase isozymes.
1987 • 47 citations
Cloning of rat liver arginase cDNA and elucidation of regulation of arginase gene expression in H4 rat hepatoma cells
1986 • 47 citations
Inhibition of herpes simplex virus multiplication by activated macrophages: a role for arginase?
1982 • 46 citations
Purification of rat kidney arginases A1 and A4 and their subcellular distribution.
1983 • 46 citations
On the structure and function of different arginases
1966 • 46 citations
Evolutionary aspects of urea cycle enzyme genes
1989 • 45 citations
The urea cycle: a two-compartment system.
1991 • 45 citations
Purification, Properties and Subunit Structure of Arginase from Iris Bulbs
1982 • 45 citations
Arginase Deficiency in Macaca fascicularis. I. Arginase Activity and Arginine Concentration in Erythrocytes and in Liver
1972 • 45 citations
Purification of Human Hepatic Arginase and Its Manganese (II)-Dependent and pH-Dependent Interconversion between Active and Inactive Forms: A Possible pH-Sensing Function of the Enzyme on the Ornithine Cycle
1995 • 44 citations
[49] Arginase
1955 • 44 citations
Molecular forms of human-liver arginase
1966 • 42 citations
Arginase of Agrobacterium Ti plasmid C58
1989 • 42 citations
Thyroid hormone-dependent differential regulation of multiple arginase genes during amphibian metamorphosis.
1994 • 42 citations
Evidence that a rat liver “inhibitor” of the synthesis of DNA in cultured mammalian cells is arginase
1967 • 42 citations
Increased arginase activity during lymphocyte mitogenesis
1978 • 42 citations
Developmental and hormonal regulation of the Xenopus liver‐type arginase gene
1993 • 41 citations
Isoenzymes of arginase in rat tissues.
1970 • 41 citations
Rat Mammary Arginase: Isolation and Characterization
1994 • 40 citations
Arginine, mitochondrial arginase, and the control of carbamyl phosphate synthesis
1981 • 40 citations
Nucleotide Sequence of Arabidopsis thaliana Arginase Expressed in Yeast
1995 • 40 citations
Serum Arginase Level in Patients with Gastric Cancer
1994 • 39 citations
Structure of the rat argininosuccinate lyase gene: close similarity to chicken delta-crystallin genes.
1989 • 38 citations
Regulation of urea and citrulline synthesis under physiological conditions
1993 • 38 citations
Nucleotide sequence of the gene encoding the repressor for the histidine utilization genes of Klebsiella aerogenes
1990 • 37 citations
Identification of mutations (D128G, H141L) in the liver arginase gene of patients with hyperargininemia
1994 • 36 citations
Enzymes of Krebs-Henseleit Cycle in Vitis vinifera L
1978 • 36 citations
In vitro analysis of the rat liver-type arginase promoter
1991 • 36 citations
Subcellular location and differential antibody specificity of arginase in tissue culture and whole animals
1994 • 35 citations
Crystallization and oligomeric structure of rat liver arginase
1992 • 35 citations
Five forms of arginase in human tissues
1988 • 34 citations
Arginine metabolism in insects: Properties of insect fat body arginase
1969 • 34 citations
Assay and kinetics of arginase
1986 • 34 citations
Effect of Nitric Oxide Synthase Substrate Analog Inhibitors on Rat Liver Arginase
1993 • 34 citations
Arginase deficiency in a 12-year-old boy with mild impairment of intellectual function
1986 • 34 citations
Arginine catabolism in the phototrophic bacterium Rhodobacter capsulatus E1F1
1992 • 33 citations
Nitrogen metabolism in channel catfish, Ictalurus punctatus—II. Evidence for an apparent incomplete ornithine-urea cycle
1973 • 33 citations
A low molecular weight arginase in the earthworm
1968 • 32 citations
Submitochondrial localization of arginase and other enzymes associated with urea synthesis and nitrogen metabolism, in liver of Squalus acanthias
1985 • 32 citations
Comparison of arginase activity in red blood cells of lower mammals, primates, and man: evolution to high activity in primates.
1985 • 32 citations
Identification of the apparently lymphocyte-specific human liver-derived inhibitory protein (LIP) as cytoplasmic liver L-arginase.
1983 • 32 citations
Purification, affinity to anti-human arginase immunoglobulin-Sepharose 4B and subunit molecular weights of mammalian arginases
1985 • 31 citations
Immobilised monomers of human liver arginase
1977 • 31 citations
Participation of ABF-1 protein in expression of the Saccharomyces cerevisiae CAR1 gene
1991 • 31 citations
Arginase activity in different fish species and tissues
1983 • 31 citations
Arginine supply for nitric oxide synthesis and arginase is mainly exogenous in elicited murine and rat macrophages
1994 • 30 citations
Molecular genetic study of human arginase deficiency.
1992 • 30 citations
Arginase as an inhibitory principle in liver plasma membranes arresting the growth of various mammalian cells in vitro
1982 • 30 citations
Cloning and expression in Escherichia coli of cDNA for arginase of rat liver
1986 • 29 citations
Localization of urea and ornithine production along mouse and rabbit nephrons: functional significance
1992 • 29 citations
New kinetic parameters for rat liver arginase measured at near-physiological steady-state concentrations of arginine and Mn2+
1992 • 29 citations
Multiple molecular forms of mouse liver arginase
1988 • 29 citations
Three novel mutations in the liver-type arginase gene in three unrelated Japanese patients with argininemia.
1992 • 28 citations
Types of Arginase in Rat Tissues
1975 • 28 citations
A simple quantitative micromethod of arginase assay in blood spots dried on filter paper
1986 • 28 citations
Induction of Urea Cycle Enzymes of Rat Liver by Amino Acids
1981 • 27 citations
Comparison of biochemical properties of liver arginase from streptozocin-induced diabetic and control mice
1989 • 27 citations
274 DEVELOPMENT OF ARGININE SYNTHESIZING ENZYMES IN MOUSE INTESTINE
1985 • 26 citations
Content of glucocorticoid receptor and arginase in gastric cancer and normal gastric mucosal tissues
1989 • 26 citations
Molecular weights of arginase from different species
1970 • 26 citations
Purification and biochemical characterization of human liver-derived inhibitory protein (LIP).
1983 • 24 citations
Steady-state kinetic studies of arginase with an improved direct spectrophotometric assay
1980 • 24 citations
Ureogenesis in a freshwater teleost: an unusual sub-cellular localization of ornithine-urea cycle enzymes in the freshwater air-breathing teleost Heteropneustes fossilis.
1991 • 23 citations
Molecular basis of argininemia. Identification of two discrete frame-shift deletions in the liver-type arginase gene.
1990 • 23 citations
Partial purification of bovine liver arginase
1956 • 23 citations
Quantitative rapid microassay of arginase
1968 • 22 citations
Structure and properties of arginase from the polychaete annelid Pista pacifica Berkeley
1974 • 21 citations
The Evolutionary History of the Ornithine Cycle as a Determinant of Its Structure and Regulation
1983 • 21 citations
Isolation and characterization of the arginase-encoding gene (arg) from Coccidioides immitis
1995 • 21 citations
Characteristics of arginases from plant, ureotelic and uricotelic organisms.
1972 • 21 citations
Differential expression of multiple forms of arginase in cultured cells
1985 • 21 citations
Steady-state fluorescence and time-resolved fluorescence monitor changes in tryptophan environment in arginase from Saccharomyces cerevisiae upon removal of catalytic and structural metal ions
1990 • 21 citations
ARGINASES OF MOUSE BRAIN AND LIVER
1977 • 20 citations
Chemical and immunological properties of B. anthracis arginase and its metabolic involvement
1983 • 20 citations
Different Species of Arginase in Animal Tissues
1973 • 20 citations
Arginine Metabolism in Mouse Brain Synaptosomes
1984 • 20 citations
Mouse Macrophage Arginase
1980 • 19 citations
Immunological properties of rat arginases.
1984 • 19 citations
The discovery of the ornithine cycle of urea synthesis
1982 • 18 citations
Ureotelism as the prevailing mode of nitrogen excretion in larvae of the marsupial frog Gastrotheca riobambae (Fowler) (Anura, Hylidae)
1992 • 18 citations
Arginase isoenzymes in human diploid fibroblasts
1975 • 17 citations
Kinetics of manganese reconstitution and thiol group exposition in dialyzed rat mammary gland arginase
1994 • 16 citations
Possible involvement of manganese in the catalytic mechanism of bovine liver arginase
1992 • 16 citations
Purification and structure of arginase of Bacillus licheniformis
1977 • 16 citations
Conversion of Arginine to Proline in the Chick
1973 • 16 citations
Subcellular localization and kinetic properties of arginase from the liver of Genypterus maculatus
1987 • 15 citations
Properties of arginase from the sea mollusc Concholepas concholepas
1984 • 15 citations
Disposal of the daily acid load: an integrated function of the liver, lungs and kidneys
1987 • 15 citations
Effect of Arginine Deficiency on Mammary Gland Development in the Rat
1982 • 14 citations
Subunit interactions and immobilised dimers of human liver arginase
1978 • 14 citations
Participation of RAP1 protein in expression of the Saccharomyces cerevisiae arginase (CAR1) gene
1993 • 14 citations
Molecular characteristics of chicken liver arginase
1972 • 14 citations
Human Salivary Arginase and Its Deficiency in Argininaemia
1985 • 14 citations
Trypsin digestion of arginase: Evidence for a stable conformation manganese directed
1992 • 14 citations
Immunological Identity of the Two Different Molecular Mass Constltutive Subunits of Liver Arginase
1994 • 13 citations
Subcellular localization of arginase in rat liver.
1980 • 12 citations
Effect of level of dietary protein on arginine-stimulated citrulline synthesis.
1990 • 12 citations
Urea cycle enzymes in retina, ciliary body-iris, lens and senile cataracts
1984 • 12 citations
Characterization of arginase activity from mouse epidermis and its relation to ornithine decarboxylase induction by the tumor-promoting agent, 12-O-tetradecanoylphorbol-13-acetate
1981 • 12 citations
Purification and properties of arginase.
1954 • 11 citations
Purification, properties and inhibition of plant arginase.
1968 • 11 citations
Arginase, ornithine decarboxylase and S-adenosylmethionine decarboxylase in chicken brain and retina
1983 • 11 citations
Relationship between two major immunoreactive forms of arginase in Neurospora crassa
1987 • 11 citations
Urea formation in rat, bovine, and human lens
1983 • 11 citations
Inhibitory Effect of Mycoplasma‐Released Arginase
1990 • 11 citations
Effects of Urea in Rats Deprived of Arginine
1973 • 10 citations
Regulation of arginase production by glucocorticoid in three human gastric cancer cell lines
1992 • 10 citations
The quaternary structure of ornithine transcarbamoylase and arginase from Saccharomyces cerevisiae.
1986 • 10 citations
Chemical modification of rat liver arginase.
1979 • 10 citations
The isolation and immunological properties of two arginase forms from human erythrocytes
1988 • 10 citations
Rat Liver Arginase Suppresses Mixed Lymphocyte Reaction
1990 • 9 citations
Resolution of multiple forms of bovine liver arginase by chromatofocusing
1991 • 9 citations
Inhibition of lymphocyte proliferation by liver arginase
1992 • 9 citations
Specificity and seasonal variation of arginase, glutamate synthase and nitrate reductase activities in scots pine needles
1989 • 8 citations
Hepatic arginase activity in intra- and extrauterine larvae of the ovoviviparous salamander, Salamandra salamandra (L.) (amphibia, urodela)
1983 • 8 citations
Properties of arginase from liver of Macaca fascicularis: Comparison of normals with red blood cell arginase deficient monkeys
1980 • 8 citations
Characterization of Murine Liver‐Derived Inhibitory Protein
1990 • 8 citations
An assay for arginase in chicken kidney
1978 • 8 citations
Hybridization of subunits of rat liver arginase A1 and rat kidney arginase A4.
1983 • 7 citations
Separation of Arginase Isoenzymes from Human Tissues by Agar Gel Electrophoresis
1976 • 7 citations
Nonidentity of subunits of human kidney arginase A1 and human liver arginase A5.
1993 • 7 citations
Purification and properties of chick kidney arginase
1979 • 6 citations
Arginase and Free Amino Acids in Hyperargininemia: Leukocyte Arginine as a Diagnostic Parameter for Heterozygotes
1979 • 6 citations
Arginase Activity in Rat Small Intestinal Mucosa
1973 • 6 citations
Physico-chemical properties of hepatocyte plasma-membrane-bound arginase.
1991 • 6 citations
Differing Effects of Arginine Deficiency on the Urea Cycle Enzymes of Rat Liver, Cultured Hepatocytes and Hepatoma Cells
1987 • 5 citations
Intestinal arginase in vertebrates and invertebrates
1978 • 4 citations
Functional and molecular analysis of liver arginase promoter sequences from man andMacaca fascicularis
1994 • 3 citations
Ornithine isn't just for the birds anymore!
1982 • 3 citations
Structure and Expression of Genes for Urea Cycle Enzymes
2015 • 2 citations
The arginase (CAR1) gene is situated near MFα1 on the right arm of chromosome XVI
1992 • 2 citations
Gel filtration behaviour of arginase in frog liver and kidney extracts
1993 • 2 citations