Enzymes of Arginine and Urea Systhesis

Untersuchungen uber die Harnstoffbildung im Tierkörper

1932 • 3,104 citations

Proteins, amino acids and peptides

1943 • 2,189 citations

The kinetics of enzyme-catalyzed reactions with two or more substrates or products☆I. Nomenclature and rate equations

1963 • 2,095 citations

The kinetics of enzyme-catalyzed reactions with two or more substrates or products

1963 • 1,885 citations

Regulation of glutamine synthetase. XII. Electron microscopy of the enzyme from Escherichia coli

1968 • 833 citations

Adaptive Characteristics of Urea Cycle Enzymes in the Rat

1962 • 738 citations

Gluconeogenesis in the perfused rat liver

1966 • 726 citations

Control of Enzyme Levels in Animal Tissues

1970 • 680 citations

Biochemistry of the Amino Acids

1957 • 530 citations

The Metabolic Basis of Inherited Disease

1972 • 478 citations

STUDIES ON THE FREE AMINO ACIDS AND RELATED COMPOUNDS IN THE TISSUES OF THE CAT

1954 • 476 citations

Comparative Biochemistry of Urea Synthesis

1959 • 409 citations

The Importance of Both Synthesis and Degradation in the Control of Arginase Levels in Rat Liver

1964 • 396 citations

NEGATIVE COOPERATIVITY IN REGULATORY ENZYMES

1969 • 382 citations

DEATH DURING THERAPEUTIC STARVATION

1968 • 360 citations

ACYL ADENYLATES: AN ENZYMATIC MECHANISM OF ACETATE ACTIVATION

1956 • 355 citations

CARBAMYL PHOSPHATE, THE CARBAMYL DONOR IN ENZYMATIC CITRULLINE SYNTHESIS¹

1955 • 349 citations

Influence of turnover rates on the responses of enzymes to cortisone.

1965 • 348 citations

The principles of human biochemical genetics

1972 • 347 citations

HYPERAMMONÆMIA

1962 • 328 citations

THE INHIBITION OF ARGINASE BY AMINO ACIDS

1945 • 327 citations

Quaternary Structure of Proteins

1970 • 297 citations

Synthesis of glutamate in Aerobacter aerogenes by a hitherto unknown route

1970 • 296 citations

Cystinuria: biochemical evidence for three genetically distinct diseases.

1966 • 290 citations

Differential Effects of Fasting and Protein-free Diets on Levels of Urea Cycle Enzymes in Rat Liver

1962 • 288 citations

Studies on Factors Affecting the Levels of Urea Cycle Enzymes in Rat Liver

1963 • 286 citations

The Dynamic State of Body Constituents

1942 • 266 citations

A DISEASE, PROBABLY HEREDITARY, CHARACTERISED BY SEVERE MENTAL DEFICIENCY AND A CONSTANT GROSS ABNORMALITY OF AMINOACID METABOLISM

1958 • 219 citations

The Biosynthesis of Carbamoyl Phosphate in Saccharomyces cerevisiae

1965 • 208 citations

Hemoglobin Kansas, a Human Hemoglobin with a Neutral Amino Acid Substitution and an Abnormal Oxygen Equilibrium

1968 • 204 citations

Ornithine Transcarbamylase from Streptococcus faecalis and Bovine Liver

1972 • 196 citations

Citrulline synthesis in rat tissues

1961 • 189 citations

Decomposition of Carbamylphosphate in Aqueous Solutions^*

1964 • 186 citations

Uses and limitations of measurements of rates of isotopic exchange and incorporation in catalyzed reactions

1959 • 182 citations

An analysis of the kinetics of rat liver tryptophan pyrrolase induction: The significance of both enzyme synthesis and degradation

1964 • 181 citations

Biochemical Differentiation during Amphibian Metamorphosis

1970 • 180 citations

Enzymes of Arginine Metabolism in Mammalian Cell Culture

1964 • 179 citations

Ornithine-δ-transaminase in the rat I. Assay and some general properties

1963 • 166 citations

Studies on Repression of Arginine Biosynthesis in Escherichia coli

1961 • 163 citations

Evidence for an Activated Form of Carbon Dioxide in the Reaction Catalyzed by Escherichia coli Carbamyl Phosphate Synthetase^*

1965 • 162 citations

Studies on the Mechanism of Glutamine Synthesis: Evidence for the Formation of Enzyme-bound Activated Glutamic Acid

1962 • 161 citations

Phosphorus Metabolism

1951 • 159 citations

Comparative biochemistry of urea synthesis. 3. Activities of urea cycle enzymes in various higher and lower vertebrates

1960 • 159 citations

ENZYMATIC SYNTHESIS OF l-PIPECOLIC ACID AND l-PROLINE

1957 • 156 citations

Glutamyl and Glutaminyl Ribonucleic Acid Synthetases of Escherichia coli W

1965 • 150 citations

Renal clearances of amino acids in normal adults and in patients with aminoaciduria

1960 • 150 citations

The Generation of Energy by the Arginine Dihydrolase Pathway in Mycoplasma hominis 07

1966 • 149 citations

Bicarbonate-Dependent Cleavage of Adenosine Triphosphate and Other Reactions Catalyzed by Escherichia coli Carbamyl Phosphate Synthetase^*

1966 • 146 citations

l-Phenylalanine ammonia-lyase

1970 • 146 citations

Studies on the Mechanism of Action and the Structure of the Electrophilic Center of Histidine Ammonia Lyase

1969 • 144 citations

GASOMETRIC AND PHOTOMETRIC MEASUREMENT OF ARGINASE ACTIVITY

1946 • 140 citations

Comparative Biochemistry of Urea Synthesis

1959 • 139 citations

Reversible Dissociation of Carbamyl Phosphate Synthetase into a Regulated Synthesis Subunit and a Subunit Required for Glutamine Utilization

1971 • 138 citations

L-Phenylalanine ammonia-lyase. II. Mechanism and kinetic properties of the enzyme from potato tubers

1968 • 136 citations

Evidence for X-Linked Dominant Inheritance of Ornithine Transcarbamylase Deficiency

1973 • 128 citations

Control of Escherichia coli Carbamyl Phosphate Synthetase by Purine and Pyrimidine Nucleotides^*

1966 • 127 citations

[Ornithine transcarbamylase deficiency].

1988 • 125 citations

THE CATALYTIC RÔLE OF CARBAMYL GLUTAMATE IN CITRULLINE BIOSYNTHESIS

1952 • 119 citations

Molecular Characteristics of Rat Liver Arginase

1968 • 117 citations

CHEMICAL AND ENZYMATIC SYNTHESIS OF CARBAMYL PHOSPHATE

1960 • 117 citations

Purification of Carbamyl Phosphate Synthetase from Frog Liver

1958 • 117 citations

The Activation of Arginyl Transfer Ribonucleic Acid Synthetase by Transfer Ribonucleic Acid

1967 • 112 citations

Structure and Function of Carbamoylphosphate Synthase

1968 • 111 citations

BIOSYNTHESIS OF UREA

1953 • 111 citations

Control of the biosynthesis of carbamoyl phosphate in Escherichia coli

1965 • 110 citations

Initial Steps in Pyrimidine Synthesis in Ehrlich Ascites Carcinoma in Vitro

1967 • 110 citations

Argininosuccinic aciduria: identification and reactions of the abnormal metabolite in a newly described form of mental disease, with some preliminary metabolic studies

1960 • 110 citations

BIOSYNTHESIS OF UREA

1953 • 107 citations

BIOSYNTHESIS OF UREA

1949 • 106 citations

Effect of adrenalectomy and of growth hormone on enzymes concerned with urea synthesis in rat liver

1963 • 104 citations

Enzymes of arginine metabolism in brain

1960 • 103 citations

Nuclear Magnetic Resonance Studies of Manganese Binding of Rat Liver Arginase

1971 • 103 citations

Role of l-Glutamine as Donor of Carbamyl Nitrogen for the Enzymatic Synthesis of Citrulline in Agaricus bisporus

1962 • 102 citations

Regulation of Rat Liver Glutamine Synthetase: Activation by α-Ketoglutarate and Inhibition by Glycine, Alanine, and Carbamyl Phosphate

1971 • 102 citations

ARGININE METABOLISM IN PLEUROPNEUMONIA-LIKE ORGANISMS ISOLATED FROM MAMMALIAN CELL CULTURE

1963 • 101 citations

Ornithine Carbamyl Transferase from Rat Liver.

1957 • 101 citations

A study of ornithine, citrulline and arginine synthesis in growing chicks

1963 • 100 citations

Biosynthesis of Urea

1965 • 99 citations

The Interconversion of Glutamic Acid and Proline

1960 • 99 citations

Selective Inactivation of the Glutamine Binding Site of Escherichia coli Carbamyl Phosphate Synthetase by 2-Amino-4-oxo-5-chloropentanoic Acid^*

1966 • 99 citations

Metabolite Distribution in Cells

1972 • 98 citations

[48] Enzymatic synthesis of arginine (condensing and splitting enzymes)

1955 • 94 citations

INFLUENCE OF PANCREATIC HORMONES ON ENZYMES CONCERNED WITH UREA SYNTHESIS IN RAT LIVER

1965 • 94 citations

Carbamyl Phosphate Synthetase: Studies on the Mechanism of Action

1958 • 93 citations

Free amino acids in the caiman and rat

1966 • 92 citations

Identification of a Reactive Cysteine Residue at the Glutamine Binding Site of Carbamyl Phosphate Synthetase

1972 • 90 citations

The Pathway of Carbonate in the Biosynthesis of Carbamyl Phosphate

1960 • 83 citations

The Mechanism of Arginine Synthesis from Citrulline in Kidney

1953 • 82 citations

Effects of pH on the kinetics of human liver ornithine-carbamyl phosphate transferase

1968 • 80 citations

Urea Cycle Enzyme Adaptation to Dietary Protein in Primates

1971 • 78 citations

Interaction between Arginase and Ornithine Carbamoyltransferase in Saccharomyces cerevisiae

1971 • 77 citations

Crystallization of catalase in the form of tubes with monomolecular walls

1967 • 76 citations

Comparative physical-chemical studies of mammalian arginases

1970 • 76 citations

Purification and Properties of a Bacterial Carbamyl Phosphate Synthetase

1966 • 75 citations

Developmental formation and distribution of arginase in rat tissues

1970 • 73 citations

Biosynthesis of Urea

1967 • 71 citations

The Role of Transfer Ribonucleic Acid in the Pyrophosphate Exchange Reaction of Arginine-Transfer Ribonucleic Acid Synthetase

1966 • 68 citations

Arsenolysis and phosphorolysis of citrulline in mammalian liver

1955 • 67 citations

Channeling in Neurospora Metabolism

1967 • 67 citations

Arginine and urea biosynthesis in the earthworm Lumbricus terrestris

1965 • 65 citations

CITRULLINURIA

1963 • 64 citations

Metabolic Adaptations in Higher Animals VI. Liver Arginase Activity During Adaptation to High Protein Diet.

1961 • 64 citations

Evidence for Two Discrete Carbamyl Phosphate Pools in Neurospora

1971 • 64 citations

Cystinuria: Genetic Heterogeneity and Allelism

1966 • 63 citations

Argininosuccinic aciduria

1967 • 63 citations

THE DISTRIBUTION OF FIXED CARBON IN AMINO ACIDS

1956 • 61 citations

Free Energy Changes of the Argininosuccinate Synthetase Reaction and of the Hydrolysis of the Inner Pyrophosphate Bond of Adenosine Triphosphate

1960 • 61 citations

EFFECT OF MALNUTRITION ON ACTIVITY OF TWO ENZYMES CONCERNED WITH AMINOACID METABOLISM IN HUMAN LIVER

1968 • 60 citations

Factors influencing the development of urea-synthesizing enzymes in rat liver

1968 • 60 citations

Congenital Hyperammonemia

1970 • 59 citations

Genetic Heterogeneity

1968 • 58 citations

Rabbit Liver l-Arginase

1972 • 58 citations

3 The Enzymic Elimination of Ammonia

1972 • 56 citations

On the availability of intramitochondrial carbamoylphosphate for the extramitochondrial biosynthesis of pyrimidines

1969 • 54 citations

AN ENZYMATIC REACTION BETWEEN CANAVANINE AND FUMARATE

1953 • 54 citations

An Immunochemical Study of Carbamyl Phosphate Synthetase

1961 • 52 citations

Pyrimidine-Specific Carbamyl Phosphate Synthetase in Neurospora crassa

1970 • 52 citations

Ammonia intoxication due to acongenital defect in urea synthesis

1964 • 52 citations

A Kinetic Study of Carbamyl Phosphate Synthetase

1964 • 52 citations

STUDY OF CITRULLINE SYNTHESIS WITH SOLUBLE ENZYME PREPARATIONS

1951 • 52 citations

Random sequential mechanism for arginyl transfer ribonucleic acid synthetase of Escherichia coli

1972 • 51 citations

Beef-Liver Arginase. Isolation and Molecular Properties

1972 • 51 citations

Immunological studies of liver, kidney, and muscle fructose 1,6-diphosphatases

1969 • 51 citations

Self-assembly of glutamic dehydrogenase into ordered superstructures: Multichain tubes formed by association of single molecules

1972 • 51 citations

Effect of allosteric effectors and adenosine triphosphate on the aggregation and rate of inhibition by N-ethylmaleimide of carbamyl phosphate synthetase of Escherichia coli

1970 • 51 citations

BIOSYNTHESIS OF UREA

1951 • 50 citations

A Kinetic Study of the Mechanism of Crystalline Carbamate Kinase

1966 • 50 citations

Arginine and Urea Biosynthesis in the Land Planarian: Its Significance in Biochemical Evolution

1965 • 49 citations

Synthesis of Carbamyl Phosphate Synthetase in Amphibian Liver in Vitro

1969 • 49 citations

Hyperargininemia with arginase deficiency a new familial metabolic disease

1970 • 49 citations

[124a] Carbamyl phosphate synthesis and utilization

1962 • 48 citations

Amino Acid Metabolism

1965 • 48 citations

Biochemical studies of the developing mammalian fetus

1959 • 47 citations

A comparative study of molluscan and mammalian arginases

1966 • 46 citations

The formation of ornithine from proline in animal tissues

1967 • 46 citations

On the structure and function of different arginases

1966 • 46 citations

Biosynthesis of Urea

1970 • 46 citations

Arginase Deficiency in Macaca fascicularis. I. Arginase Activity and Arginine Concentration in Erythrocytes and in Liver

1972 • 45 citations

Separation and Properties of Argininosuccinate and Its Two Anhydrides and Their Detection in Biological Materials^*

1966 • 44 citations

Arginine biosynthesis and metabolism in terrestrial snails

1968 • 44 citations

Studies on the Mechanism of Action of Acetylglutamate as an Activator of Carbamyl Phosphate Synthetase

1964 • 44 citations

Symmetry of protein oligomers formed by isologous association

1966 • 44 citations

Structure and Function of Carbamoylphosphate Synthetase. On the Mechanism of Bicarbonate Activation

1969 • 43 citations

Argininosuccinase deficiency in fibroblasts cultured from patients with argininosuccinic aciduria

1969 • 43 citations

Enzymic Reaction Between Arginine and Fumarate in Plant and Animal Tissues

1952 • 42 citations

Citrullinemia with defective urea production.

1967 • 41 citations

Fructose diphosphatase from rabbit muscle

1969 • 40 citations

Biosynthesis of Urea

1972 • 40 citations

CITRULLINEMIA WITH DEFECTIVE UREA PRODUCTION

1967 • 40 citations

Biosynthesis of Urea

1961 • 39 citations

Activity of Aspartate Transcarbamylase in Heart and Liver of the Developing Rat

1964 • 37 citations

Structure of the tubes of catalase: Analysis of electron micrographs by optical filtering

1968 • 37 citations

Biosynthesis of Urea

1958 • 36 citations

Ammonia Detoxication in Liver from Humans.

1961 • 36 citations

Purification of ornithine transcarbamylase from derepressed cells of Escherichia coli W

1962 • 35 citations

Role for Pancreas in Biosynthesis of Creatine.

1958 • 35 citations

Argininosuccinase from bovine kidney: Comparison of catalytic, physical, and chemical properties with the enzyme from bovine liver

1971 • 33 citations

A Concerted Response of the Enzymes of Urea Biosynthesis during Thyroxine-induced Metamorphosis of Rana catesbeiana

1972 • 33 citations

Mammalian Histidine Ammonia Lyase

1970 • 32 citations

Characterization of the reactive sulfhydryl groups in carbamyl phosphate synthetase of Escherichia coli

1971 • 31 citations

THE ENZYMATIC MECHANISM OF ARGININE FORMATION FROM CITRULLINE

1947 • 31 citations

Influence of glucagon, 6-N,2′-O-dibutyryladenosine 3′:5′-cyclic monophosphate and triamcinolone on the arginine synthetase system in perinatal rat liver

1972 • 30 citations

Decrease in thermal stability of frog liver carbamyl phosphate synthetase by substrates and cofactors

1959 • 30 citations

Rapid short-column chromatography of amino acids

1967 • 30 citations

Arginine and urea metabolism in terrestrial snails

1969 • 29 citations

Further Studies on the Mechanism of Action of Carbamyl Phosphate Synthetase

1959 • 27 citations

Argininosuccinase Activity in Brain Tissue

1960 • 26 citations

Biosynthesis of Urea

1964 • 26 citations

Molecular weights of arginase from different species

1970 • 26 citations

Studies on the Action of Hydrazine, Hydroxylamine, and Other Amines in the Carbamyl Phosphate Synthetase Reaction

1967 • 25 citations

Arginine Synthesis in Neurospora crassa; Genetic Studies

1957 • 24 citations

VARIATION WITH AGE OF THE ENZYMES OF THE UREA CYCLE AND ASPARTATE TRANSCARBAMYLASE IN RAT LIVER

1967 • 24 citations

LETHAL NEONATAL HYPERAMMONÆMIA DUE TO COMPLETE ORNITHINE-TRANSCARBAMYLASE DEFICIENCY

1971 • 23 citations

Studies on the mechanism of action of carbamate kinase

1962 • 23 citations

Neurospora crassa Mutants Lacking Argininosuccinase

1957 • 23 citations

Regulation of arginine and ornithine metabolism at the enzymic level in rat liver and kidney

1967 • 20 citations

366. Kinetic and tracer studies of the reactions of carbamoyl phosphate in aqueous solution

1962 • 18 citations

Crystalline ornithine transcarbamylase

1967 • 18 citations

Crystallization of Arginase from Normal and Cirrhotic Human Liver

1965 • 18 citations

Nuclear magnetic resonance study of the anhydrides of argininosuccinic acid and related guanidino compounds

1969 • 17 citations

Conversion of argininosuccinic acid to citrulline coupled to ATP formation

1956 • 17 citations

Determination of Argininosuccinic Acid by Ion-Exchange Chromatography

1961 • 17 citations

Ornithine transcarbamylase: Steady-state kinetic properties

1971 • 16 citations

Purification and properties of carbamate kinase from Streptococcus faecalis

1964 • 15 citations

Urea cycle enzymes in the liver of a patient with argininosuccinic aciduria.

1967 • 15 citations

Urea Synthesis in Rats treated with α-D,L-Methylaspartic Acid

1962 • 14 citations

The carbamyl phosphate content of rabbit blood plasma

1964 • 13 citations

Urea production from labelled ammonia in arginino-succinic aciduria

1969 • 12 citations

A study of carbamyl phosphate synthesis in Streptococcus lactis

1961 • 12 citations

Studies on the function of N-acyl glutamates in the carbamyl phosphate synthetase reaction

1966 • 11 citations

Effects of analogues of aspartic acid on enzymes of urea synthesis

1968 • 11 citations

Tubular organization of crystalline argininosuccinase

1971 • 10 citations

Purification of argininosuccinase fromNeurosporaand comparison of some properties of the wild-type enzyme and an enzyme formed by inter-allelic complementation

1966 • 10 citations

A radioisotopic assay system for enzymes of the ornithine-urea cycle

1970 • 7 citations

Optical diffraction of electron micrographs of argininosuccinase tubules

1971 • 6 citations

Activity of urea cycle enzymes in the liver and urea excretion in the rat during development.

1968 • 5 citations