Engineering peptides and proteins that undergo α-to-β transitions

Circular Dichroism and the Conformational Analysis of Biomolecules

1996 • 1,897 citations

NMR structure of the mouse prion protein domain PrP(121–231)

1996 • 1,251 citations

Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis

1997 • 1,041 citations

Arrest of -Amyloid Fibril Formation by a Pentapeptide Ligand

1996 • 905 citations

Alternative conformations of amyloidogenic proteins govern their behavior

1996 • 596 citations

The Acid-Mediated Denaturation Pathway of Transthyretin Yields a Conformational Intermediate That Can Self-Assemble into Amyloid

1996 • 546 citations

Inhibition of Alzheimer's Amyloidosis by Peptides That Prevent β-Sheet Conformation

1996 • 420 citations

Context-dependent secondary structure formation of a designed protein sequence

1996 • 395 citations

Structural model for the β-amyloid fibril based on interstrand alignment of an antiparallel-sheet comprising a C-terminal peptide

1995 • 393 citations

Specific aggregation of partially folded polypeptide chains: The molecular basis of inclusion body composition

1996 • 307 citations

Prolines and Aamyloidogenicity in Fragments of the Alzheimer's Peptide .beta./A4

1995 • 306 citations

Structure of Amyloid A4‐(1–40)‐Peptide of Alzheimer's Disease

1995 • 296 citations

Solvent effects on self-assembly of beta-amyloid peptide

1995 • 271 citations

Non-native α-helical intermediate in the refolding of β-lactoglobulin, a predominantly β-sheet protein

1996 • 259 citations

Selective Inhibition of Aβ Fibril Formation

1996 • 229 citations

Nicotine Inhibits Amyloid Formation by the β-Peptide

1996 • 218 citations

Comparison of Lethal and Nonlethal Transthyretin Variants and Their Relationship to Amyloid Disease

1995 • 195 citations

Prion Protein Peptides Induce .alpha.-Helix to .beta.-Sheet Conformational Transitions

1995 • 192 citations

Scrapie prions: a three-dimensional model of an infectious fragment

1996 • 191 citations

Aggregates of scrapie-associated prion protein induce the cell-free conversion of protease-sensitive prion protein to the protease-resistant state

1995 • 188 citations

High-Level Expression and Characterization of a Purified 142-Residue Polypeptide of the Prion Protein

1996 • 188 citations

Conformational Transformations in Peptides Containing Two Putative α-Helices of the Prion Protein

1995 • 178 citations

High Helical Propensity of the Peptide Fragments Derived from β-Lactoglobulin, a Predominantly β-sheet Protein

1995 • 173 citations

1H NMR of A.beta. Amyloid Peptide Congeners in Water Solution. Conformational Changes Correlate with Plaque Competence

1995 • 171 citations

X-ray Diffraction of Scrapie Prion Rods and PrP Peptides

1995 • 165 citations

Point Substitution in the Central Hydrophobic Cluster of a Human β-Amyloid Congener Disrupts Peptide Folding and Abolishes Plaque Competence

1996 • 158 citations

For Protein Misassembly, It's the “I” Decade

1996 • 153 citations

Fibrillogenesis of synthetic amyloid-β peptides is dependent on their initial secondary structure

1995 • 148 citations

De novo protein design: from molten globules to native-like states

1993 • 145 citations

Misfolding the Way to Disease

1996 • 132 citations

The Burst-phase Intermediate in the Refolding of β-Lactoglobulin Studied by Stopped-flow Circular Dichroism and Absorption Spectroscopy

1996 • 126 citations

The conformation of Alzheimer's β peptide determines the rate of amyloid formation and its resistance to proteolysis

1996 • 118 citations

Conformational switching in designed peptides: the helix/sheet transition

1996 • 111 citations

Specificity of Abnormal Assembly in Immunoglobulin Light Chain Deposition Disease and Amyloidosis

1996 • 109 citations

Prion protein (PrP) synthetic peptides induce cellular PrP to acquire properties of the scrapie isoform.

1995 • 108 citations

Partial Unfolding and Refolding of Scrapie-Associated Prion Protein: Evidence for a Critical 16-kDa C-Terminal Domain

1996 • 107 citations

Native-like and structurally characterized designed α-helical bundles

1995 • 90 citations

Three-Dimensional Structures of the Amyloid β Peptide (25−35) in Membrane-Mimicking Environment

1996 • 85 citations

Redox-Triggered Secondary Structure Changes in the Aggregated States of a Designed Methionine-Rich Peptide

1996 • 84 citations

Solid‐state NMR studies of the prion protein H1 fragment

1996 • 83 citations

High helicity of peptide fragments corresponding to β-strand regions of β-lactoglobulin observed by 2D-NMR spectroscopy

1996 • 76 citations

Folding intermediates are involved in genetic diseases?

1995 • 75 citations

Nucleated Antiparallel β-Sheet That Folds and Undergoes Self-Assembly: A Template Promoted Folding Strategy toward Controlled Molecular Architectures

1996 • 52 citations

Amyloid in alzheimer's disease and prion-related encephalopathies: Studies with synthetic peptides

1996 • 50 citations

Prion diseases and the ‘protein only’ hypothesis: a theoretical dynamic study

1996 • 47 citations

Structures of Prion Proteins and Conformational Models for Prion Diseases

1996 • 41 citations

Stopped-Flow Circular Dichroism

1996 • 40 citations

Correlation among Secondary Structure, Amyloid Precursor Protein Accumulation, and Neurotoxicity of Amyloid β(25–35) Peptide as Analyzed by Single Alanine Substitution

1995 • 36 citations

Induction of α-Helix in the β-Sheet Protein Tumor Necrosis Factor-α: Thermal- and Trifluoroethanol-Induced Denaturation at Neutral pH

1996 • 33 citations

Induction of α-Helix in the β-Sheet Protein Tumor Necrosis Factor-α: Acid-Induced Denaturation

1996 • 27 citations

Conformational Analysis of the β-amyloid Peptide Fragment, β(12–28)

1995 • 25 citations

The double life of the prion protein

1996 • 17 citations

The Folding Intermediate Concept of Prion Protein Formation and Conformational Links to Infectivity

1996 • 14 citations

Sequence Effects on Helix-Sheet Conformational Transitions of Designed Amphiphilic Peptides

1996 • 11 citations

Transgenetics of Prion Diseases

1996 • 7 citations

Design and Synthesis of Peptide Misfolding from α to β Structure and Regulation by β-Cyclodextrin as Mini-Molecular Chaperone

1996 • 1 citations