The Folding Intermediate Concept of Prion Protein Formation and Conformational Links to Infectivity

Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.

1993 • 2,237 citations

The molten globule state as a clue for understanding the folding and cooperativity of globular‐protein structure

1989 • 1,446 citations

Principles of protein structure

1980 • 1,094 citations

Principles of Protein Structure

1979 • 1,090 citations

PATHWAYS OF PROTEIN FOLDING

1993 • 435 citations

Protein folding: local structures, domains, subunits, and assemblies

1991 • 432 citations

A kinetic model for amyloid formation in the prion diseases: importance of seeding.

1993 • 391 citations

Conformational transitions, dissociation, and unfolding of scrapie amyloid (prion) protein.

1993 • 369 citations

A 'unified theory' of prion propagation

1991 • 304 citations

Thermal stability and conformational transitions of scrapie amyloid (prion) protein correlate with infectivity

1993 • 204 citations

Genetic and Infectious Prion Diseases

1993 • 175 citations

A simple and effective method for inactivating virus infectivity in formalin‐fixed tissue samples from patients with Creutzfeldt‐Jakob disease

1990 • 140 citations

scrapie Amyloid (Prion) Protein Has the Conformational Characteristics of an Aggregated Molten Globule Folding Intermediate

1994 • 113 citations

Secondary structure of proteins associated in thin films

1993 • 52 citations

Transmissible and nontransmissible dementias: distinction between primary cause and pathogenetic mechanisms in Alzheimer's disease and aging.

1988 • 27 citations