Laminin isoforms in tumor invasion, angiogenesis and metastasis

The Hallmarks of Cancer

2000 • 27,569 citations

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

The microenvironment of the tumour–host interface

2001 • 2,307 citations

Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis

1977 • 1,286 citations

Form and function: The laminin family of heterotrimers

2000 • 1,226 citations

Angiogenesis and Tumor Metastasis

1998 • 1,013 citations

Epiligrin, a new cell adhesion ligand for integrin α3β1 in epithelial basement membranes

1991 • 771 citations

Kalinin: an epithelium-specific basement membrane adhesion molecule that is a component of anchoring filaments.

1991 • 755 citations

The Laminin α Chains: Expression, Developmental Transitions, and Chromosomal Locations of α1-5, Identification of Heterotrimeric Laminins 8–11, and Cloning of a Novel α3 Isoform

1997 • 661 citations

Role of Cell Surface Metalloprotease Mt1-Mmp in Epithelial Cell Migration over Laminin-5

2000 • 650 citations

Activation of Phosphoinositide 3-OH Kinase by the α6β4 Integrin Promotes Carcinoma Invasion

1997 • 615 citations

ECM signalling: orchestrating cell behaviour and misbehaviour

1998 • 537 citations

Loss of basement membrane components by invasive tumors but not by their benign counterparts.

1983 • 497 citations

Endothelial Cell Laminin Isoforms, Laminins 8 and 10, Play Decisive Roles in T Cell Recruitment across the Blood–Brain Barrier in Experimental Autoimmune Encephalomyelitis

2001 • 487 citations

Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition

2002 • 486 citations

Canstatin, a Novel Matrix-derived Inhibitor of Angiogenesis and Tumor Growth

2000 • 461 citations

Anti-angiogenic cues from vascular basement membrane collagen.

2000 • 412 citations

Laminin mediates tissue-specific gene expression in mammary epithelia.

1995 • 397 citations

Laminin-5 is a marker of invading cancer cells in some human carcinomas and is coexpressed with the receptor for urokinase plasminogen activator in budding cancer cells in colon adenocarcinomas.

1995 • 383 citations

Cooperative interactions of laminin 5 gamma2 chain, matrix metalloproteinase-2, and membrane type-1-matrix/metalloproteinase are required for mimicry of embryonic vasculogenesis by aggressive melanoma.

2001 • 359 citations

Deletion of the Laminin α4 Chain Leads to Impaired Microvessel Maturation

2002 • 335 citations

Processing of Laminin-5 and Its Functional Consequences: Role of Plasmin and Tissue-type Plasminogen Activator

1998 • 310 citations

The role of laminins in basement membrane function

1998 • 303 citations

Structure and function of laminin LG modules

2000 • 281 citations

Endothelial cell proliferation during angiogenesis. In vitro modulation by basement membrane components.

1986 • 277 citations

The gamma 2 chain of kalinin/laminin 5 is preferentially expressed in invading malignant cells in human cancers.

1994 • 271 citations

Developmental Regulation of the Laminin α5 Chain Suggests a Role in Epithelial and Endothelial Cell Maturation

1997 • 261 citations

The α3 laminin subunit, α6β4 and α3β1 integrin coordinately regulate wound healing in cultured epithelial cells and in the skin

1999 • 255 citations

Kalinin is more efficient than laminin in promoting adhesion of primary keratinocytes and some other epithelial cells and has a different requirement for integrin receptors.

1994 • 252 citations

Integrin binding specificity of laminin-10/11: laminin-10/11 are recognized by α3β1, α6β1 and α6β4 integrins

2000 • 227 citations

Laminin receptors: achieving specificity through cooperation

1995 • 225 citations

Towards a mechanistic understanding of tumor invasion—lessons from theα 6 β 4integrin

2001 • 216 citations

Distinct and overlapping ligand specificities of the alpha 3A beta 1 and alpha 6A beta 1 integrins: recognition of laminin isoforms.

1994 • 204 citations

Overexpression of laminin gamma2 chain monomer in invading gastric carcinoma cells.

1999 • 201 citations

Laminin 5 Deposition Promotes Keratinocyte Motility

1996 • 185 citations

Identification of laminin alpha1 and beta1 chain peptides active for endothelial cell adhesion, tube formation, and aortic sprouting.

1999 • 180 citations

Cellular Interaction of Integrin α3β1 with Laminin 5 Promotes Gap Junctional Communication

1998 • 169 citations

Laminin Isoforms and Epithelial Development

1998 • 166 citations

Integrin α3β1-mediated interaction with laminin-5 stimulates adhesion, migration and invasion of malignant glioma cells

1998 • 166 citations

Laminin α1-Chain Shows a Restricted Distribution in Epithelial Basement Membranes of Fetal and Adult Human Tissues

2000 • 164 citations

A large cell-adhesive scatter factor secreted by human gastric carcinoma cells.

1993 • 161 citations

Purification and Characterization of Human Laminin-8

2001 • 159 citations

Laminin-5 as a Marker of Invasiveness in Cervical Lesions

1999 • 157 citations

Human microvascular endothelial cells use beta 1 and beta 3 integrin receptor complexes to attach to laminin.

1990 • 155 citations

A Cell Signal Pathway Involving Laminin-5, α3β1 Integrin, and Mitogen-activated Protein Kinase Can Regulate Epithelial Cell Proliferation

1999 • 155 citations

Laminin receptors and laminin-binding proteins during tumor invasion and metastasis.

1993 • 154 citations

Identification of laminin α1 and β1 chain peptides active for endothelial cell adhesion, tube formation, and aortic sprouting

1999 • 151 citations

The functions of laminins: Lessons from in vivo studies

1996 • 148 citations

Platelets and Cancer Metastasis: More Than an Epiphenomenon

1992 • 145 citations

Cloning of the Mouse Laminin α4 cDNA. Expression in a Subset of Endothelium

1997 • 137 citations

Angiogenesis inhibitor endostatin is a distinct component of elastic fibers in vessel walls

1999 • 136 citations

Keratinocyte migration requires α2β1 integrin-mediated interaction with the laminin 5 γ2 chain

2001 • 135 citations

Recombinant Human Laminin-10 (α5β1γ1)

2002 • 132 citations

Recombinant Laminin-8 (α4β1γ1)

2000 • 130 citations

Cell Adhesion and Migration Properties of β2-Integrin Negative Polymorphonuclear Granulocytes on Defined Extracellular Matrix Molecules

2001 • 129 citations

Laminins promote the locomotion of skeletal myoblasts via the alpha 7 integrin receptor

1996 • 124 citations

Characterization of Bone Marrow Laminins and Identification of 5-Containing Laminins as Adhesive Proteins for Multipotent Hematopoietic FDCP-Mix Cells

1999 • 123 citations

Expression of Laminin α1, α2, α4, and α5 Chains, Fibronectin, and Tenascin-C in Skeletal Muscle of Dystrophic 129ReJdy/dyMice

1999 • 123 citations

Overexpression of alpha4 chain-containing laminins in human glial tumors identified by gene microarray analysis.

2001 • 120 citations

Integrin expression in cutaneous malignant melanoma: Association of the α₃/β₁ heterodimer with tumor progression

1993 • 113 citations

Pancreatic carcinomas deposit laminin-5, preferably adhere to laminin-5, and migrate on the newly deposited basement membrane.

1997 • 109 citations

Characterization and functional analysis of laminin isoforms in human bone marrow

2000 • 102 citations

Identification of Endothelial Cell Binding Sites on the Laminin γ1 Chain

1999 • 99 citations

The LG3 Module of Laminin-5 Harbors a Binding Site for Integrin α3β1 That Promotes Cell Adhesion, Spreading, and Migration

2001 • 98 citations

Domain IVa of laminin α5 chain is cell‐adhesive and binds β1 and αVβ3 integrins through Arg‐Gly‐Asp

2001 • 94 citations

Co-regulation and Physical Association of the 67-kDa Monomeric Laminin Receptor and the α6β4 Integrin

1997 • 91 citations

Identification of laminin-10/11 as a strong cell adhesive complex for a normal and a malignant human epithelial cell line

1999 • 90 citations

Merosin promotes cell attachment and neurite outgrowth and ls a component of the neurite-promoting factor of RN22 schwannoma cells

1992 • 90 citations

An angiogenic laminin site and its antagonist bind through the αvβ3 and α5β1 integrins

2001 • 82 citations

Developmental Expression and Cellular Origin of the Laminin α2, α4, and α5 Chains in the Intestine

1999 • 80 citations

Insights into Extracellular Matrix Functions from Mutant Mouse Models

2000 • 77 citations

Comparative Analysis of the Distribution of Laminin Chains in the Basement Membranes in Some Malignant Epithelial Tumors: The α1 Chain of Laminin Shows a Selected Expression Pattern in Human Carcinomas

2001 • 76 citations

Expression of Laminin α₃, α₄, and α₅ Chains by Alveolar Epithelial Cells and Fibroblasts

1998 • 75 citations

Confocal Microscopic Analysis of Integrin Expression on the Microvasculature and its Sprouts in the Neonatal Foreskin

1994 • 75 citations

Laminin-8 (α4β1γ1) is synthesized by lymphoid cells, promotes lymphocyte migration and costimulates T cell proliferation

2001 • 71 citations

Human colonic cancer cells synthesize and adhere to laminin-5. Their adhesion to laminin-5 involves multiple receptors among which is integrin α2β1

1998 • 68 citations

Integrin α3β1 Engagement Disrupts Intercellular Adhesion

2001 • 67 citations

Blood Platelets Contain and Secrete Laminin-8 (α4β1γ1) and Adhere to Laminin-8 via α6β1 Integrin

1999 • 65 citations

Basement-membrane components associated with the extracellular matrix of the lymph node

1988 • 65 citations

Laminin-binding integrins in tumor progression and metastasis

1996 • 65 citations

Monocytic Cells Synthesize, Adhere to, and Migrate on Laminin-8 (α4β1γ1)

2000 • 64 citations

Role of laminin in endothelial cell recognition and differentiation

1993 • 61 citations

Expression of Laminins 1 and 10 in Carcinoma Cells and Comparison of Their Roles in Cell Adhesion

1999 • 59 citations

Laminin‐5 γ2 Chain Expression Correlates with Unfavorable Prognosis in Colon Carcinomas

2001 • 58 citations

Loss of laminin‐5 in the epithelium–stroma interface: an immunohistochemical marker of malignancy in epithelial lesions of the breast

1999 • 58 citations

Expression of the alpha7beta1 laminin receptor suppresses melanoma growth and metastatic potential.

1999 • 53 citations

Basement membrane laminin‐5 is deposited in colorectal adenomas and carcinomas and serves as a ligand for α₃β₁ integrin

2000 • 45 citations

Overexpression of laminin ?1 chain in colonic cancer cells induces an increase in tumor growth

2001 • 43 citations

A Comparative Quantitative Analysis of Laminin-5 in the Basement Membrane of Normal, Hyperplastic, and Malignant Oral Mucosa by Confocal Immunofluorescence Imaging

2001 • 42 citations

Tumor microvessels in melanoma express the beta‐2 chain of laminin. Implications for melanoma metastasis

1999 • 42 citations

Angio-tumoral complex in human malignant melanoma characterised by free laminin: ultrastructural and immunohistochemical observations.

1997 • 39 citations

Evidence for the location of a binding sequence for the α2β1 integrin of endothelial cells, in the β1 subunit of laminin

1995 • 39 citations

Laminin isoforms 8 and 10 are primary components of the subendothelial basement membrane promoting interaction with neoplastic lymphocytes.

2001 • 35 citations

Pericytes from Microvessel Fragment Produce Type IV Collagen and Multiple Laminin Isoforms

1996 • 29 citations

Down‐regulation of α6 integrin, an anti‐oncogene product, by functional cooperation of H‐Ras and c‐Myc

2001 • 13 citations

Metastatic melanoma cells interact with the reticular fibres of the lymph node

1994 • 7 citations

Analysis of Laminin Structure and Function with Recombinant Glycoprotein Expressed in Insect Cells

2003 • 4 citations

Deleted Work

1955 • 0 citations