Transmodulation between Phospholipase D and c-Src Enhances Cell Proliferation

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES

1997 • 2,470 citations

Regulation, substrates and functions of src

1996 • 1,173 citations

SIGNALLING BY RECEPTOR TYROSINE KINASES

1993 • 1,098 citations

Crystal Structures of c-Src Reveal Features of Its Autoinhibitory Mechanism

1999 • 850 citations

Role of Src expression and activation in human cancer

2000 • 832 citations

Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization

1997 • 698 citations

Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation

1987 • 648 citations

Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation

1995 • 603 citations

Characterization of Two Alternately Spliced Forms of Phospholipase D1

1997 • 547 citations

The when and how of Src regulation

1993 • 543 citations

Role of c-Src Tyrosine Kinase in G Protein-coupled Receptorand Gβγ Subunit-mediated Activation of Mitogen-activated Protein Kinases

1996 • 524 citations

Src Tyrosine Kinase Is a Novel Direct Effector of G Proteins

2000 • 422 citations

Cell Transformation by the Viral src Oncogene

1987 • 405 citations

Selected glimpses into the activation and function of Src kinase

2000 • 402 citations

Regulation of phospholipase D

1999 • 369 citations

Phospholipase D and Its Product, Phosphatidic Acid, Mediate Agonist-dependent Raf-1 Translocation to the Plasma Membrane and the Activation of the Mitogen-activated Protein Kinase Pathway

1999 • 297 citations

Involvement of Ral GTPase in v-Src-induced phospholipase D activation

1995 • 261 citations

Role for Phospholipase D in Receptor-Mediated Endocytosis

2001 • 216 citations

Genetics of src: Structure and Functional Organization of a Protein Tyrosine Kinase

1989 • 197 citations

Involvement of Tyrosine Phosphorylation and Protein Kinase C in the Activation of Phospholipase D by H2O2 in Swiss 3T3 Fibroblasts

1998 • 171 citations

Overexpression of phospholipase D1 in human breast cancer tissues

2000 • 160 citations

Molecular Analysis of Mammalian Phospholipase D2

1999 • 157 citations

Increased Activity and Intranuclear Expression of Phospholipase D2 in Human Renal Cancer

2000 • 135 citations

The Phox homology (PX) domain, a new player in phosphoinositide signalling

2001 • 128 citations

α-Synuclein Interacts with Phospholipase D Isozymes and Inhibits Pervanadate-induced Phospholipase D Activation in Human Embryonic Kidney-293 Cells

2002 • 125 citations

Immunolocalization of the cellular src protein in interphase and mitotic NIH c-src overexpresser cells.

1990 • 120 citations

Phospholipase D structure and regulation

1999 • 118 citations

PLD2 Complexes with the EGF Receptor and Undergoes Tyrosine Phosphorylation at a Single Site upon Agonist Stimulation

1998 • 116 citations

c-Src-dependent Activation of the Epidermal Growth Factor Receptor and Mitogen-activated Protein Kinase Pathway by Arsenic

2002 • 112 citations

Phospholipase D and RalA Cooperate with the Epidermal Growth Factor Receptor To Transform 3Y1 Rat Fibroblasts

2000 • 100 citations

Phospholipase C-gamma 1 can induce DNA synthesis by a mechanism independent of its lipase activity.

1994 • 97 citations

The Phox homology (PX) domain, a new player in phosphoinositide signalling

2001 • 90 citations

Phospholipase D activity in human gastric carcinoma.

1999 • 89 citations

Ras Mediates the Activation of Phospholipase D by v-Src

1995 • 87 citations

rlk/TXK Encodes Two Forms of a Novel Cysteine String Tyrosine Kinase Activated by Src Family Kinases

1999 • 86 citations

Regulation of phospholipase D by phosphorylation-dependent mechanisms

1999 • 86 citations

Human Phospholipase D1 Can Be Tyrosine-phosphorylated in HL-60 Granulocytes

1997 • 85 citations

Phospholipase D1 Is Phosphorylated and Activated by Protein Kinase C in Caveolin-enriched Microdomains within the Plasma Membrane

2000 • 83 citations

Increased phospholipase D activity in human breast cancer

1997 • 83 citations

Antagonistic Effects of Protein Kinase C α and δ on Both Transformation and Phospholipase D Activity Mediated by the Epidermal Growth Factor Receptor

1999 • 76 citations

Neoplastic transformation and tumorigenesis associated with overexpression of phospholipase D isozymes in cultured murine fibroblasts

2001 • 75 citations

Regulation of phospholipase D by tyrosine kinases

1996 • 64 citations

Phospholipase D activation by the mitogens platelet‐derived growth factor and 12‐O‐tetradecanoylphorbol 13‐acetate in NIH‐3T3 cells

1989 • 64 citations

Ral and Rho-Dependent Activation of Phospholipase D in v-Raf-Transformed Cells

1999 • 60 citations

Phospholipase D Activation by Norepinephrine Is Mediated by 12(S)-, 15(S)-, and 20-Hydroxyeicosatetraenoic Acids Generated by Stimulation of Cytosolic Phospholipase A2

2001 • 59 citations

Transformation of Cells Overexpressing a Tyrosine Kinase by Phospholipase D1 and D2

2001 • 59 citations

Expression and regulation of phospholipase D during neuronal differentiation of PC12 cells

2001 • 55 citations

Epidermal growth factor‐induced hydrolysis of phosphatidylcholine by phospholipase D and phospholipase C in human dermal fibroblasts

1991 • 54 citations

Intracellular Signaling by Phospholipase D as a Therapeutic Target

2001 • 51 citations

Monosodium urate-crystal-stimulated phospholipase D in human neutrophils

1999 • 47 citations

Integrin Engagement, the Actin Cytoskeleton, and c-Src Are Required for the Calcitonin-induced Tyrosine Phosphorylation of Paxillin and HEF1, but Not for Calcitonin-induced Erk1/2 Phosphorylation

2000 • 46 citations

Collapsin Response Mediator Protein-2 Inhibits Neuronal Phospholipase D2 Activity by Direct Interaction

2002 • 43 citations

Phosphatidic Acid Regulates Tyrosine Phosphorylating Activity in Human Neutrophils

2001 • 42 citations

Phosphatidic acid elicits calcium mobilization and actin polymerization through a tyrosine kinase-dependent process in human neutrophils: a mechanism for induction of chemotaxis

1997 • 41 citations

Role of p38 MAP kinase in diperoxovanadate-induced phospholipase D activation in endothelial cells

2001 • 32 citations

Evidence that v-Src-induced phospholipase D activity is mediated by a G protein.

1994 • 27 citations

Differential Tyrosine Phosphorylation of Phospholipase D Isozymes by Hydrogen Peroxide and the Epidermal Growth Factor in A431 Epidermoid Carcinoma Cells

2001 • 24 citations

Signalling by Src Family Kinases: Lessons Learnt from DNA Tumour Viruses

1997 • 13 citations

Modulation of phospholipase D stimulation in c-src transfected mesangial cells

1997 • 4 citations