Targeting of an Apical Endosomal Protein to Endosomes in Madin–Darby Canine Kidney Cells Requires Two Sorting Motifs

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia.

1986 • 1,588 citations

ENDOCYTOSIS AND MOLECULAR SORTING

1996 • 1,537 citations

Rab11 regulates recycling through the pericentriolar recycling endosome.

1996 • 1,293 citations

Endocytosis

1997 • 1,263 citations

Protein Sorting by Transport Vesicles

1996 • 1,168 citations

Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic

1991 • 832 citations

Brefeldin A inhibits Golgi membrane-catalysed exchange of guanine nucleotide onto ARF protein

1992 • 741 citations

Phosphoinositides as Regulators in Membrane Traffic

1996 • 717 citations

MHC class II-associated invariant chain contains a sorting signal for endosomal compartments

1990 • 565 citations

N-glycans as apical sorting signals in epithelial cells

1995 • 454 citations

The Receptor Recycling Pathway Contains Two Distinct Populations of Early Endosomes with Different Sorting Functions

1999 • 446 citations

Actin microfilaments play a critical role in endocytosis at the apical but not the basolateral surface of polarized epithelial cells.

1993 • 438 citations

Polarity of Epithelial and Neuronal Cells

1992 • 435 citations

Mechamisms of cell polarity: sorting and transport in epithelial cells

1994 • 430 citations

Association of Rab25 and Rab11a with the Apical Recycling System of Polarized Madin–Darby Canine Kidney Cells

1999 • 391 citations

Receptor-mediated transcytosis of IgA in MDCK cells is via apical recycling endosomes.

1994 • 384 citations

PACS-1 Defines a Novel Gene Family of Cytosolic Sorting Proteins Required for trans-Golgi Network Localization

1998 • 372 citations

Characterization of ZO-1, a protein component of the tight junction from mouse liver and Madin-Darby canine kidney cells.

1988 • 366 citations

Protein targeting by tyrosine- and di-leucine-based signals: evidence for distinct saturable components.

1996 • 314 citations

A di-leucine-based motif in the cytoplasmic tail of LIMP-II and tyrosinase mediates selective binding of AP-3

1998 • 298 citations

The O-glycosylated Stalk Domain Is Required for Apical Sorting of Neurotrophin Receptors in Polarized MDCK Cells

1997 • 279 citations

Endocytosis in filter-grown Madin-Darby canine kidney cells.

1989 • 264 citations

A di-leucine motif mediates endocytosis and basolateral sorting of macrophage IgG Fc receptors in MDCK cells.

1994 • 253 citations

Structural requirements and sequence motifs for polarized sorting and endocytosis of LDL and Fc receptors in MDCK cells.

1994 • 242 citations

Meeting of the apical and basolateral endocytic pathways of the Madin-Darby canine kidney cell in late endosomes.

1989 • 226 citations

ADP-Ribosylation Factor 1 (ARF1) Regulates Recruitment of the AP-3 Adaptor Complex to Membranes

1998 • 215 citations

Phosphoinositides in membrane traffic

1999 • 212 citations

Carbohydrate-mediated Golgi to cell surface transport and apical targeting of membrane proteins

1998 • 212 citations

VIP17/MAL, a lipid raft-associated protein, is involved in apical transport in MDCK cells

1999 • 203 citations

Mutations in the Middle of the Transmembrane Domain Reverse the Polarity of Transport of the Influenza Virus Hemagglutinin in MDCK Epithelial Cells

1998 • 192 citations

Basolateral to apical transcytosis in polarized cells is indirect and involves BFA and trimeric G protein sensitive passage through the apical endosome

1994 • 186 citations

The SNARE Machinery Is Involved in Apical Plasma Membrane Trafficking in MDCK Cells

1998 • 181 citations

The Kinetics and Mechanism of Iron (III) Exchange between Chelates and Transferrin

1971 • 180 citations

Protein and lipid sorting from thetrans–Golgi network to the plasma membrane in polarized cells

1998 • 179 citations

The AP-1 adaptor complex binds to immature secretory granules from PC12 cells, and is regulated by ADP-ribosylation factor.

1996 • 178 citations

A Casein Kinase II Phosphorylation Site in the Cytoplasmic Domain of the Cation-dependent Mannose 6-Phosphate Receptor Determines the High Affinity Interaction of the AP-1 Golgi Assembly Proteins with Membranes

1996 • 173 citations

Interaction of furin in immature secretory granules from neuroendocrine cells with the AP-1 adaptor complex is modulated by casein kinase II phosphorylation

1997 • 173 citations

A role for synaptic vesicles in non‐neuronal cells: clues from pancreatic β cells and from chromaffin cells

1994 • 167 citations

The MAL Proteolipid Is Necessary for Normal Apical Transport and Accurate Sorting of the Influenza Virus Hemagglutinin in Madin-Darby Canine Kidney Cells

1999 • 164 citations

A tyrosine-based motif and a casein kinase II phosphorylation site regulate the intracellular trafficking of the varicella-zoster virus glycoprotein I, a protein localized in the trans-Golgi network.

1996 • 153 citations

Synaptic vesicle proteins and early endosomes in cultured hippocampal neurons: differential effects of Brefeldin A in axon and dendrites

1993 • 148 citations

The Cytoplasmic Tail of Rhodopsin Acts as a Novel Apical Sorting Signal in Polarized MDCK Cells

1998 • 148 citations

Rab17 Regulates Membrane Trafficking through Apical Recycling Endosomes in Polarized Epithelial Cells

1998 • 141 citations

Regulation of protein traffic in polarized epithelial cells.

1995 • 138 citations

Apical and basolateral endosomes of MDCK cells are interconnected and contain a polarized sorting mechanism.

1996 • 135 citations

Cation-dependent mannose 6-phosphate receptor contains two internalization signals in its cytoplasmic domain.

1990 • 121 citations

Apical Plasma Membrane Proteins and Endolyn-78 Travel through a Subapical Compartment in Polarized WIF-B Hepatocytes

1998 • 111 citations

Effects of brefeldin A on endocytosis, transcytosis and transport to the Golgi complex in polarized MDCK cells.

1992 • 105 citations

Medium Chains of Adaptor Complexes AP-1 and AP-2 Recognize Leucine-based Sorting Signals from the Invariant Chain

1998 • 104 citations

Both Microtubules and Actin Filaments Are Required for Efficient Postendocytotic Traffic of the Polymeric Immunoglobulin Receptor in Polarized Madin-Darby Canine Kidney Cells

1997 • 100 citations

Regulation of Endosome Sorting by a Specific PP2A Isoform

1998 • 99 citations

A Tyrosine-Based Signal Targets H/K-ATPase to a Regulated Compartment and Is Required for the Cessation of Gastric Acid Secretion

1997 • 98 citations

Sorting Mechanisms Regulating Membrane Protein Traffic in the Apical Transcytotic Pathway of Polarized MDCK Cells

1998 • 97 citations

Identification of Sorting Determinants in the C-terminal Cytoplasmic Tails of the γ-Aminobutyric Acid Transporters GAT-2 and GAT-3

1998 • 95 citations

Chapter 11 Cytomegalovirus Plasmid Vectors for Permanent Lines of Polarized Epithelial Cells

1994 • 90 citations

Re-expression of the Mannose 6-Phosphate Receptors in Receptor-deficient Fibroblasts

1996 • 83 citations

Membrane protein trafficking through the common apical endosome compartment of polarized Caco-2 cells.

1995 • 83 citations

Basolateral Sorting of Furin in MDCK Cells Requires a Phenylalanine-Isoleucine Motif Together with an Acidic Amino Acid Cluster

1999 • 81 citations

Selective Perturbation of Apical Membrane Traffic by Expression of Influenza M2, an Acid-activated Ion Channel, in Polarized Madin–Darby Canine Kidney Cells

1998 • 66 citations

Evidence for Apical Endocytosis in Polarized Hepatic Cells: Phosphoinositide 3-Kinase Inhibitors Lead to the Lysosomal Accumulation of Resident Apical Plasma Membrane Proteins

1999 • 63 citations

Endocytosis, intracellular transport and transcytosis of the toxic protein ricin by a polarized epithelium.

1990 • 61 citations

Phosphorylation Regulates the Delivery of MHC Class II Invariant Chain Complexes to Antigen Processing Compartments

1998 • 60 citations

Identification of an endosomal antigen specific to absorptive cells of suckling rat ileum.

1987 • 60 citations

Convergence of apical and basolateral endocytic pathways at apical late endosomes in absorptive cells of suckling rat ileum in vivo

1990 • 57 citations

Nonvectorial Surface Transport, Endocytosis via a Di-leucine-based Motif, and Bidirectional Transcytosis of Chimera Encoding the Cytosolic Tail of Rat FcRn Expressed in Madin-Darby Canine Kidney Cells

1999 • 44 citations

Serine phosphorylation site of the 46-kDa mannose 6-phosphate receptor is required for transport to the plasma membrane in Madin-Darby canine kidney and mouse fibroblast cells.

1997 • 41 citations

Endosomal pathways for water channel and proton pump recycling in kidney epithelial cells

1993 • 41 citations

Tyrosine-dependent Basolateral Sorting Signals Are Distinct from Tyrosine-dependent Internalization Signals

1997 • 35 citations

Basolateral Sorting of the Cation-dependent Mannose 6-Phosphate Receptor in Madin-Darby Canine Kidney Cells

1998 • 33 citations

Structural Requirements for Major Histocompatibility Complex Class II Invariant Chain Trafficking in Polarized Madin-Darby Canine Kidney Cells

1997 • 32 citations

Targeting of an Intestinal Apical Endosomal Protein to Endosomes in Nonpolarized Cells

1997 • 29 citations

Identification of a Leu-Ile internalization motif within the cytoplasmic domain of the leukaemia inhibitory factor receptor

1999 • 29 citations

Traffic of synaptic vesicle proteins in polarized and nonpolarized cells

1993 • 29 citations

Polarized Apical Targeting Directed by the Signal/Anchor Region of Simian Virus 5 Hemagglutinin-Neuraminidase

1997 • 28 citations

A mono phenylalanine-based motif (F790) and a leucine-dependent motif (LI760) mediate internalization of furin

1999 • 20 citations

Polarized transport of MHC class II molecules in Madin-Darby canine kidney cells is directed by a leucine-based signal in the cytoplasmic tail of the beta-chain.

1999 • 19 citations

The N-terminal segment of endothelin-converting enzyme (ECE)-1b contains a di-leucine motif that can redirect neprilysin to an intracellular compartment in Madin–Darby canine kidney (MDCK) cells

1999 • 17 citations

Polarized Transport of MHC Class II Molecules in Madin-Darby Canine Kidney Cells Is Directed by a Leucine-Based Signal in the Cytoplasmic Tail of the β-Chain

1999 • 17 citations

Molecular Characterization of an Apical Early Endosomal Glycoprotein from Developing Rat Intestinal Epithelial Cells

1995 • 15 citations

Changes in the concentration of ions during senescence of the human erythrocyte.

1993 • 14 citations

The N-terminal segment of endothelin-converting enzyme (ECE)-1b contains a di-leucine motif that can redirect neprilysin to an intracellular compartment in Madin‒Darby canine kidney (MDCK) cells

1999 • 9 citations

Vesicular transport: implications for cell polarity.

1996 • 9 citations