Ligation of the OX40 co‐stimulatory receptor reverses self‐Ag and tumor‐induced CD8 T‐cell anergy in vivo

Tolerogenic Dendritic Cells

2003 • 3,131 citations

Immunosuppressive Strategies that are Mediated by Tumor Cells

2006 • 1,662 citations

Cytokines in cancer pathogenesis and cancer therapy

2004 • 1,465 citations

T Cell Anergy

2003 • 1,418 citations

TNF/TNFR FAMILY MEMBERS IN COSTIMULATION OF T CELL RESPONSES

2004 • 1,320 citations

TGF-β directly targets cytotoxic T cell functions during tumor evasion of immune surveillance

2005 • 1,173 citations

Cross-Presentation, Dendritic Cells, Tolerance and Immunity

2001 • 894 citations

Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?

2003 • 848 citations

Does the Immune System See Tumors as Foreign or Self?

2003 • 746 citations

OX40 Promotes Bcl-xL and Bcl-2 Expression and Is Essential for Long-Term Survival of CD4 T Cells

2001 • 638 citations

The enemy within: keeping self-reactive T cells at bay in the periphery

2002 • 586 citations

Triggering of OX40 (CD134) on CD4+CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR

2005 • 406 citations

OX40 costimulation turns off Foxp3+ Tregs

2007 • 398 citations

The OX40 Costimulatory Receptor Determines the Development of CD4 Memory by Regulating Primary Clonal Expansion

2000 • 395 citations

Engagement of the OX-40 Receptor In Vivo Enhances Antitumor Immunity

2000 • 386 citations

OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection

2008 • 383 citations

Boosting antitumor responses of T lymphocytes infiltrating human prostate cancers

2005 • 377 citations

T Cell Stimulation In Vivo by Lipopolysaccharide (LPS)

1997 • 335 citations

Distinct Roles for the OX40-OX40 Ligand Interaction in Regulatory and Nonregulatory T Cells

2004 • 305 citations

Signaling through OX40 (CD134) breaks peripheral T-cell tolerance

2001 • 235 citations

Peripheral Tolerance of CD8 T Lymphocytes

2005 • 227 citations

Danger and OX40 Receptor Signaling Synergize to Enhance Memory T Cell Survival by Inhibiting Peripheral Deletion

2000 • 222 citations

Phenotypic and Functional Analysis of Cd8+ T Cells Undergoing Peripheral Deletion in Response to Cross-Presentation of Self-Antigen

2001 • 220 citations

A Natural Immunological Adjuvant Enhances T Cell Clonal Expansion through a CD28-dependent, Interleukin (IL)-2–independent Mechanism

1998 • 220 citations

During Viral Infection of the Respiratory Tract, CD27, 4-1BB, and OX40 Collectively Determine Formation of CD8+ Memory T Cells and Their Capacity for Secondary Expansion

2005 • 210 citations

Therapeutic efficacy of OX-40 receptor antibody depends on tumor immunogenicity and anatomic site of tumor growth.

2000 • 196 citations

Costimulation of CD8 T Cell Responses by OX40

2004 • 176 citations

OX40 Agonist Therapy Enhances CD8 Infiltration and Decreases Immune Suppression in the Tumor

2008 • 162 citations

Down-regulation of ?-chain expression in T cells: a biomarker of prognosis in cancer?

2004 • 150 citations

TNF-α is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist–deficient mice

2004 • 122 citations

Presence of the T-cell activation marker OX-40 on tumor infiltrating lymphocytes and draining lymph node cells from patients with melanoma and head and neck cancers

1997 • 119 citations

OX40: targeted immunotherapy - implications for tempering autoimmunity and enhancing vaccines

2002 • 112 citations

Dominance of CD4⁺ lymphocytic infiltrates with disturbed effector cell characteristics in the tumor microenvironment of prostate carcinoma

2007 • 112 citations

OX40 Costimulation Synergizes with GM-CSF Whole-Cell Vaccination to Overcome Established CD8+ T Cell Tolerance to an Endogenous Tumor Antigen

2006 • 105 citations

Functional Dichotomy between OX40 and 4-1BB in Modulating Effector CD8 T Cell Responses

2006 • 103 citations

Engagement of OX40 Enhances Antigen-Specific CD4+ T Cell Mobilization/Memory Development and Humoral Immunity: Comparison of αOX-40 with αCTLA-4

2001 • 99 citations

Anti‐OX40 stimulation in vivo enhances CD8⁺ memory T cell survival and significantly increases recall responses

2006 • 95 citations

Distinct Requirements for Deletion versus Anergy during CD8 T Cell Peripheral Tolerance In Vivo

2005 • 91 citations

Tolerization of Tumor-Specific T Cells Despite Efficient Initial Priming in a Primary Murine Model of Prostate Cancer

2007 • 90 citations

Defects in the Acquisition of CD8 T Cell Effector Function after Priming with Tumor or Soluble Antigen Can Be Overcome by the Addition of an OX40 Agonist

2007 • 87 citations

A Signal through OX40 (CD134) Allows Anergic, Autoreactive T Cells to Acquire Effector Cell Functions

2004 • 87 citations

OX40 and Bcl-xL Promote the Persistence of CD8 T Cells to Recall Tumor-Associated Antigen

2005 • 84 citations

Induction of Anti-Mammary Cancer Immunity by Engaging the OX-40 Receptor in Vivo

2001 • 80 citations

The CD8⁺ T cell repertoire against Her‐2/neu antigens in neu transgenic mice is of low avidity with antitumor activity

2004 • 73 citations

Defective Proximal TCR Signaling Inhibits CD8+ Tumor-Infiltrating Lymphocyte Lytic Function

2005 • 72 citations

IL-12 Is Required for Anti-OX40-Mediated CD4 T Cell Survival

2008 • 69 citations

Anti-OX40 (CD134) Administration to Nonhuman Primates: Immunostimulatory Effects and Toxicokinetic Study

2006 • 57 citations

Targeting OX40 and OX40L for the Treatment of Autoimmunity and Cancer

2007 • 56 citations

Molecular transfer of CD40 and OX40 ligands to leukemic human B cells induces expansion of autologous tumor–reactive cytotoxic T lymphocytes

2004 • 55 citations

Mechanisms of T Cell Tolerance and Suppression in Cancer Mediated by Tumor-Associated Antigens and Hormones

2007 • 34 citations

Deletion is neither sufficient nor necessary for the induction of peripheral tolerance in mature CD8⁺ T cells

2006 • 33 citations