Tyrosine phosphorylation of focal adhesion kinase by PDGF is dependent on Ras in human hepatic stellate cells

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

1994 • 1,590 citations

The Cellular Basis of Hepatic Fibrosis -- Mechanisms and Treatment Strategies

1993 • 1,444 citations

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1993 • 1,077 citations

Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras

1997 • 1,064 citations

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

1993 • 972 citations

K- and N-Ras Are Geranylgeranylated in Cells Treated with Farnesyl Protein Transferase Inhibitors

1997 • 848 citations

Platelet-derived growth factor receptor signals.

1994 • 561 citations

Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase.

1994 • 516 citations

Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: the potential for multiplex signalling

1996 • 503 citations

Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex.

1995 • 503 citations

Integrin signalling and tyrosine phosphorylation: just the FAKs?

1998 • 502 citations

Spatial and temporal aspects of cellular calcium signaling

1996 • 480 citations

A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase

1994 • 477 citations

Coupling of Ras and Rac Guanosine Triphosphatases Through the Ras Exchanger Sos

1998 • 452 citations

Regulation of chemotaxis by the platelet-derived growth factor receptor-β

1994 • 441 citations

Book Review Ethical Problems in Dialysis and Transplantation (Developments in Nephrology. Vol. 33.) Edited by Carl M. Kjellstrand and John B. Dossetor. 235 pp., illustrated. Boston, Kluwer Academic, 1992. $108.50. 0-7923-1625-8

1993 • 329 citations

Platelet-derived growth factor modulation of focal adhesion kinase (p125FAK) and paxillin tyrosine phosphorylation in Swiss 3T3 cells. Bell-shaped dose response and cross-talk with bombesin.

1994 • 305 citations

Expression of platelet-derived growth factor and its receptors in normal human liver and during active hepatic fibrogenesis.

1996 • 279 citations

Focal adhesion kinase: at the crossroads of signal transduction

1997 • 260 citations

Regulation of extracellular matrix synthesis by transforming growth factor β1 in human fat-storing cells

1993 • 230 citations

Characterization of Ha-Ras, N-Ras, Ki-Ras4A, and Ki-Ras4B as in Vitro Substrates for Farnesyl Protein Transferase and Geranylgeranyl Protein Transferase Type I

1997 • 203 citations

Position independence and proper developmental control of gamma-globin gene expression require both a 5' locus control region and a downstream sequence element.

1994 • 194 citations

Novel insights into the biology and physiology of the Ito cell

1995 • 181 citations

Disruption of Oncogenic K-Ras4B Processing and Signaling by a Potent Geranylgeranyltransferase I Inhibitor

1995 • 176 citations

Focal adhesion kinase and phospholipase C gamma involvement in adhesion and migration of human hepatic stellate cells

1997 • 125 citations

Platelet-derived Growth Factor Receptor Tyrosine Phosphorylation Requires Protein Geranylgeranylation but not Farnesylation

1996 • 119 citations

The chemotactic response to PDGF-BB: evidence of a role for Ras.

1995 • 116 citations

Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation.

1994 • 113 citations

Differential Effects of Platelet-derived Growth Factor BB on p125 Focal Adhesion Kinase and Paxillin Tyrosine Phosphorylation and on Cell Migration in Rabbit Aortic Vascular Smooth Muscle Cells and Swiss 3T3 Fibroblasts

1995 • 113 citations

Requirement for Phosphatidylinositol 3′-Kinase Activity in Platelet-derived Growth Factor-stimulated Tyrosine Phosphorylation of p125 Focal Adhesion Kinase and Paxillin

1996 • 108 citations

The mitogenic effect of platelet-derived growth factor in human hepatic stellate cells requires calcium influx

1995 • 66 citations

Structure of the c-Ki-ras Gene in a Rat Fibrosarcoma Induced by 1,8-Dinitropyrene

1986 • 53 citations

Knockout of α6β1-integrin expression reverses the transformed phenotype of hepatocarcinoma cells

1998 • 44 citations

Ca2+ channel activation by platelet-derived growth factor-induced tyrosine phosphorylation and Ras guanine triphosphate-binding proteins in rat glomerular mesangial cells.

1996 • 37 citations

Ca(2+)-permeable channel associated with platelet-derived growth factor receptor in mesangial cells

1994 • 30 citations