Effects of long-term therapy with bosentan on the progression of left ventricular dysfunction and remodeling in dogs with heart failure

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system.

1991 • 2,017 citations

Plasma endothelin correlates with the extent of pulmonary hypertension in patients with chronic congestive heart failure.

1992 • 653 citations

Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist.

1994 • 650 citations

Inhibition of myocardial endothelin pathway improves long-term survival in heart failure

1996 • 630 citations

Usefulness and limitations of radiographic methods for determining left ventricular volume

1966 • 622 citations

Effects of angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor antagonists in rats with heart failure. Role of kinins and angiotensin II type 2 receptors.

1997 • 603 citations

Endothelin in human congestive heart failure.

1994 • 598 citations

Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes.

1993 • 576 citations

Evidence for endothelin-1-mediated vasoconstriction in severe chronic heart failure

1995 • 575 citations

Endothelin-1 induces hypertrophy with enhanced expression of muscle-specific genes in cultured neonatal rat cardiomyocytes.

1991 • 505 citations

Integrated cardiac, renal, and endocrine actions of endothelin.

1989 • 481 citations

Plasma endothelin determination as a prognostic indicator of 1-year mortality after acute myocardial infarction.

1994 • 404 citations

Role of Endogenous Endothelin in Chronic Heart Failure

1997 • 367 citations

Remodeling and reparation of the cardiovascular system

1992 • 323 citations

Short-Term Oral Endothelin-Receptor Antagonist Therapy in Conventionally Treated Patients With Symptomatic Severe Chronic Heart Failure

1998 • 292 citations

A canine model of chronic heart failure produced by multiple sequential coronary microembolizations

1991 • 291 citations

Effects of endothelins on collagen turnover in cardiac fibroblasts

1993 • 290 citations

Increased endothelin in experimental heart failure.

1990 • 288 citations

Endogenous Endothelin-1 Participates in the Maintenance of Cardiac Function in Rats With Congestive Heart Failure

1996 • 287 citations

Endothelin and increased contractility in adult rat ventricular myocytes. Role of intracellular alkalosis induced by activation of the protein kinase C-dependent Na(+)-H+ exchanger.

1991 • 286 citations

Reactive and reparative myocardial fibrosis in arterial hypertension in the rat

1992 • 268 citations

Endothelin ETA receptor antagonist blocks cardiac hypertrophy provoked by hemodynamic overload.

1994 • 252 citations

Significance of Ventricular Myocytes and Nonmyocytes Interaction During Cardiocyte Hypertrophy

1997 • 238 citations

Endothelin-1-induced vasoconstriction in humans. Reversal by calcium channel blockade but not by nitrovasodilators or endothelium-derived relaxing factor.

1991 • 216 citations

Endothelins ¹

1991 • 213 citations

Effects of long-term monotherapy with enalapril, metoprolol, and digoxin on the progression of left ventricular dysfunction and dilation in dogs with reduced ejection fraction.

1994 • 207 citations

Vasodilator Effects of Endothelin-Converting Enzyme Inhibition and Endothelin ET _A Receptor Blockade in Chronic Heart Failure Patients Treated With ACE Inhibitors

1996 • 180 citations

Cardiac Endothelin-1 Plays a Critical Role in the Functional Deterioration of Left Ventricles During the Transition From Compensatory Hypertrophy to Congestive Heart Failure in Salt-Sensitive Hypertensive Rats

1998 • 163 citations

Progression of heart failure: A role for interstitial fibrosis

1995 • 163 citations

Chronic Endothelin Receptor Blockade Attenuates Progressive Ventricular Dilation and Improves Cardiac Function in Rats With Myocardial Infarction

1997 • 157 citations

Endothelin-A receptor mediates cardiac inhibition by regulating calcium and potassium currents

1994 • 152 citations

Endothelin-1 Is Involved in Norepinephrine-Induced Ventricular Hypertrophy In Vivo

1996 • 144 citations

Concomitant Endothelin Receptor Subtype-A Blockade During the Progression of Pacing-Induced Congestive Heart Failure in Rabbits

1997 • 127 citations

Endothelin in experimental congestive heart failure in the anesthetized dog

1990 • 117 citations

Endothelin A Receptor Blockade Causes Adverse Left Ventricular Remodeling but Improves Pulmonary Artery Pressure After Infarction in the Rat

1998 • 115 citations

Endothelin-1 and Angiotensin II Receptors in Cells From Rat Hypertrophied Heart

1996 • 114 citations

Characterization of Endothelin-1 Stimulation of Catecholamine Release from Adrenal Chromaffin Cells

1989 • 93 citations

Endothelins. Myocardial actions of a new class of cytokines.

1992 • 74 citations

Short-term Hemodynamic Effects of Endothelin Receptor Blockade in Dogs With Chronic Heart Failure

1996 • 74 citations

Acute and short-term effects of the nonpeptide endothelin-1 receptor antagonist bosentan in humans

1997 • 62 citations

Phorbol Myristate Acetate-induced Hypertrophy of Neonatal Rat Cardiac Myocytes is Associated with Decreased Sarcoplasmic Reticulum Ca2+ATPase (SERCA2) Gene Expression and Calcium Reuptake

1996 • 55 citations

Endothelin stimulates degradation of phospholipids in isolated rat hearts

1991 • 51 citations

Pharmacological properties of endothelin receptor subtypes mediating positive inotropic effects in rabbit heart

1994 • 43 citations

Molecular biology of collagen matrix in the heart

1995 • 33 citations

A dual-component positive inotropic effect of endothelin-1 in guinea pig left atria: a role of protein kinase C.

1993 • 24 citations

Endothelin regulation of cardiac contractility in absence of added endothelin

1995 • 22 citations

Inhibition of cyclic AMP accumulation by endothelin is pertussis toxin sensitive and calcium independent in isolated adult feline cardiac myocytes

1995 • 21 citations

Effects of the ET_A/ET_B receptor antagonist, bosentan on endothelin‐1‐induced myocardial ischaemia and oedema in the rat

1995 • 19 citations