Concomitant Endothelin Receptor Subtype-A Blockade During the Progression of Pacing-Induced Congestive Heart Failure in Rabbits

Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure.

1986 • 1,297 citations

Plasma endothelin correlates with the extent of pulmonary hypertension in patients with chronic congestive heart failure.

1992 • 653 citations

Endothelin in human congestive heart failure.

1994 • 598 citations

Evidence for endothelin-1-mediated vasoconstriction in severe chronic heart failure

1995 • 575 citations

Both ETA and ETB receptors mediate contraction to endothelin-1 in human blood vessels.

1994 • 521 citations

Endothelin-1 induces hypertrophy with enhanced expression of muscle-specific genes in cultured neonatal rat cardiomyocytes.

1991 • 505 citations

Molecular and cellular mechanism of endothelin regulation. Implications for vascular function.

1991 • 391 citations

Remodeling and reparation of the cardiovascular system

1992 • 323 citations

Neurohormonal activation in patients with right ventricular failure from pulmonary hypertension: Relation to hemodynamic variables and endothelin levels

1995 • 315 citations

Increased endothelin in experimental heart failure.

1990 • 288 citations

Endogenous Endothelin-1 Participates in the Maintenance of Cardiac Function in Rats With Congestive Heart Failure

1996 • 287 citations

Endothelin and increased contractility in adult rat ventricular myocytes. Role of intracellular alkalosis induced by activation of the protein kinase C-dependent Na(+)-H+ exchanger.

1991 • 286 citations

Characterization and localization of endothelin receptor subtypes in the human atrioventricular conducting system and myocardium.

1993 • 262 citations

Myocardial Blood Flow Response to Pacing Tachycardia and to Dipyridamole Infusion in Patients With Dilated Cardiomyopathy Without Overt Heart Failure

1995 • 207 citations

Endothelin-1 is an autocrine/paracrine growth factor for human cancer cell lines.

1991 • 198 citations

Endothelin has biological actions at pathophysiological concentrations.

1991 • 191 citations

Abnormalities in intracellular calcium regulation and contractile function in myocardium from dogs with pacing-induced heart failure.

1992 • 169 citations

Relation between endothelin-1 spillover in the lungs and pulmonary vascular resistance in patients with chronic heart failure

1994 • 168 citations

Endothelin enhances the contractile responsiveness of adult rat ventricular myocytes to calcium by a pertussis toxin-sensitive pathway.

1990 • 165 citations

Role of endothelin in the maintenance of blood pressure in conscious rats with chronic heart failure. Acute effects of the endothelin receptor antagonist Ro 47-0203 (bosentan).

1994 • 165 citations

Comparative neurohormonal responses in patients with preserved and impaired left ventricular ejection fraction: Results of the studies of left ventricular dysfunctions (SOLVD) registry

1993 • 153 citations

Endothelin-A receptor mediates cardiac inhibition by regulating calcium and potassium currents

1994 • 152 citations

Defective endothelium-mediated control of coronary circulation in conscious dogs after heart failure

1994 • 145 citations

Relation between ventricular and myocyte remodeling with the development and regression of supraventricular tachycardia-induced cardiomyopathy.

1991 • 123 citations

Changes in myocardial blood flow during development of and recovery from tachycardia-induced cardiomyopathy.

1992 • 122 citations

Increased In Vivo Expression and Production of Endothelin-1 by Porcine Cardiomyocytes Subjected to Ischemia

1995 • 122 citations

Relation between ventricular and myocyte function with tachycardia-induced cardiomyopathy.

1992 • 120 citations

In Vitro Biological Profile of a Highly Potent Novel Endothelin (ET) Antagonist BQ-123 Selective for the ETA Receptor

1992 • 116 citations

Endothelin-1 and Angiotensin II Receptors in Cells From Rat Hypertrophied Heart

1996 • 114 citations

Discovery of a Novel Series of Orally Active Non-Peptide Endothelin-A (ETA) Receptor-Selective Antagonists

1995 • 109 citations

Enhanced Coronary Vasoconstriction to Endothelin-BReceptor Activation in Experimental Congestive Heart Failure

1996 • 107 citations

Angiotensin-Converting Enzyme Inhibition and the Progression of Congestive Cardiomyopathy

1995 • 105 citations

Inhibition of the cardiac protein kinase A-dependent chloride conductance by endothelin-1

1994 • 90 citations

Myosin Synthesis and Degradation during Development of Cardiac Hypertrophy in the Rabbit

1972 • 87 citations

Endothelin activates voltage‐dependent Ca2+ current by a G protein‐dependent mechanism in rabbit cardiac myocytes.

1992 • 77 citations

Endothelins. Myocardial actions of a new class of cytokines.

1992 • 74 citations

Pharmacological characterization of PD 156707, an orally active ETA receptor antagonist.

1995 • 69 citations

Myocyte electrophysiological properties following the development of supraventricular tachycardia-induced cardiomyopathy

1995 • 67 citations

Haemodynamic and neurohumoral response in heart failure produced by rapid ventricular pacing

1992 • 65 citations

Structure‐Function Relationships of Endothelins, Sarafotoxins, and Their Receptor Subtypes

1992 • 63 citations

Downregulation of cardiac guanosine 5'-triphosphate-binding proteins in right atrium and left ventricle in pacing-induced congestive heart failure.

1993 • 62 citations

Cellular and molecular alterations in the adrenergic system with cardiomyopathy induced by tachycardia

1994 • 58 citations

Angiotensin II and phorbol-esters potently down-regulate endothelin (ET-1) binding sites in vascular smooth muscle cells

1989 • 55 citations

Human saphenous vein contains both endothelin ETA and ETB contractile receptors

1994 • 50 citations

Endothelin stimulates multiple responses in isolated adult ventricular cardiac myocytes

1992 • 43 citations

Concentration- and time-dependence of phosphoinositide hydrolysis induced by endothelin-1 in relation to the positive inotropic effect in the rabbit ventricular myocardium.

1992 • 41 citations

Effect of Endothelin-1 on Actomyosin ATPase Activity

1996 • 31 citations

Myocardial ischaemia induced by endothelin in the intact rabbit: angiographic analysis

1990 • 28 citations

Effects of chronic supraventricular pacing tachycardia on relaxation rate in isolated cardiac muscle cells

1995 • 26 citations

Altered sarcolemmal calcium channel density and Ca2+-pump ATPase activity in tachycardia heart failure

1994 • 25 citations

Functional coupling between endothelin receptors and multiple G-proteins in rat heart myocytes.

1993 • 24 citations

Evidence of an endothelin-1 autocrine loop in cardiac myocytes: Relation to contractile function with congestive heart failure

1996 • 22 citations

Molecular Biology and Pharmacology of the Endothelins

1995 • 22 citations

Left ventricular and myocyte structure and function following chronic ventricular tachycardia in rabbits

1994 • 18 citations

Myocardial depression produced by sustained tachycardia in rabbits

1992 • 17 citations

Regulation of the Endothelin-1 Transmembrane Signaling Pathway: the Potential Role of Agonist-Induced Desensitization in the Coronary Artery of the Rapid Ventricular Pacing-Overdrive Dog Model of Heart Failure

1993 • 14 citations

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