Endothelin-1 Is Involved in Norepinephrine-Induced Ventricular Hypertrophy In Vivo

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

DETERMINATION OF SERUM PROTEINS BY MEANS OF THE BIURET REACTION

1949 • 16,078 citations

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

Cloning and expression of a cDNA encoding an endothelin receptor

1990 • 2,590 citations

Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor

1990 • 2,432 citations

Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene

1985 • 1,836 citations

Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology.

1994 • 1,631 citations

Circulating and Tissue Endothelin Immunoreactivity in Advanced Atherosclerosis

1991 • 967 citations

Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload.

1988 • 877 citations

Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist.

1994 • 650 citations

Polar secretion of endothelin-1 by cultured endothelial cells.

1992 • 650 citations

Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes. A paracrine mechanism for myocardial cell hypertrophy

1990 • 641 citations

Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes.

1993 • 576 citations

Endothelin is a potent mitogen for rat vascular smooth muscle cells

1989 • 509 citations

Endothelin-1 induces hypertrophy with enhanced expression of muscle-specific genes in cultured neonatal rat cardiomyocytes.

1991 • 505 citations

The endothelin ETB receptor mediates both vasodilation and vasoconstriction in vivo

1992 • 405 citations

Cellular signaling by peptides of the endothelin gene family

1990 • 391 citations

Analysis of Tissues and Body Fluids for Nitrogenous Constituents

1969 • 325 citations

Growth factor activity of endothelin on vascular smooth muscle

1990 • 325 citations

Effects of endothelins on collagen turnover in cardiac fibroblasts

1993 • 290 citations

Neonatal atria and ventricles secrete atrial natriuretic factor via tissue-specific secretory pathways

1986 • 283 citations

Alpha-skeletal muscle actin mRNA's accumulate in hypertrophied adult rat hearts.

1986 • 282 citations

Tissue Endothelin-1 Immunoreactivity in the Active Coronary Atherosclerotic Plaque

1995 • 280 citations

Natriuretic peptides inhibit angiotensin II-induced proliferation of rat cardiac fibroblasts by blocking endothelin-1 gene expression.

1995 • 267 citations

Characterization and localization of endothelin receptor subtypes in the human atrioventricular conducting system and myocardium.

1993 • 262 citations

Endothelin ETA receptor antagonist blocks cardiac hypertrophy provoked by hemodynamic overload.

1994 • 252 citations

Co-regulation of the atrial natriuretic factor and cardiac myosin light chain-2 genes during alpha-adrenergic stimulation of neonatal rat ventricular cells. Identification of cis sequences within an embryonic and a constitutive contractile protein gene which mediate inducible expression.

1991 • 244 citations

Endothelin: Potential Role in Hypertension and Vascular Hypertrophy

1995 • 240 citations

cDNA cloning, sequence analysis and tissue distribution of rat preproendothelin-1 mRNA

1991 • 226 citations

Organ distribution of the three rat endothelin messenger RNAs and the effects of ischemia on renal gene expression.

1992 • 216 citations

The cardiac beta-myosin heavy chain isogene is induced selectively in alpha 1-adrenergic receptor-stimulated hypertrophy of cultured rat heart myocytes.

1990 • 200 citations

Role of endothelin in the maintenance of blood pressure in conscious rats with chronic heart failure. Acute effects of the endothelin receptor antagonist Ro 47-0203 (bosentan).

1994 • 165 citations

Circulating and tissue endothelin immunoreactivity in hypercholesterolemic pigs.

1993 • 161 citations

Ventricular atriopeptin. Unmasking of messenger RNA and peptide synthesis by hypertrophy or dexamethasone.

1987 • 150 citations

Switches in cardiac muscle gene expression as a result of pressure and volume overload

1992 • 119 citations

Endothelin receptors in cultured adult rat cardiac fibroblasts

1993 • 90 citations

Cis-acting sequences that modulate atrial natriuretic factor gene expression.

1988 • 85 citations

Endothelin-1 and its binding sites are upregulated in pressure overload cardiac hypertrophy

1995 • 85 citations

Gene expression in cardiac hypertrophy

1992 • 77 citations

Complete nucleotide sequence of full length cDNA for rat α cardiac myosin hea chain

1989 • 68 citations

Clenbuterol Induces Hypertrophy of the Latissimus Dorsi Muscle and Heart in the Rat With Molecular and Phenotypic Changes

1995 • 61 citations

Up-Regulation of ETB Receptor Subtype mRNA by Angiotensin II in Rat Cardiomyocytes

1993 • 60 citations

Coupling of the type A endothelin receptor to multiple responses in adult rat cardiac myocytes.

1994 • 60 citations

Effect of thyroid hormone on the accumulation of mRNA for skeletal and cardiac alpha-actin in hearts from normal and hypophysectomized rats.

1990 • 60 citations

Inhibition of the release of arachidonic acid prevents the development of sarcolemmal membrane defects in cultured rat myocardial cells during adenosine triphosphate depletion.

1988 • 56 citations

Stimulation of adult rat ventricular myocyte protein synthesis and phosphoinositide hydrolysis by the endothelins

1993 • 56 citations

Production of endothelin by cultured porcine endothelial cells: modulation by adrenaline

1989 • 52 citations

Complete nudeotide sequence of full length cDNA for rat β cardiac myosin heavy chain

1989 • 42 citations

MOLECULAR BIOLOGY OF THE CARDIOVASCULAR SYSTEM

1991 • 41 citations

Characterization of endothelin-1-induced vascular effects in the rat heart by using endothelin receptor antagonists

1994 • 34 citations

Two Subtypes of the Endothelin Receptor (ETA and ETB) Mediate Vasoconstriction in the Perfused Rat Heart

1993 • 31 citations

Release of endothelin from cultured bovine endothelial cells

1991 • 30 citations

Enzyme immunometric assay for endothelin using tandem monoclonal antibodies

1993 • 26 citations

Mammalian protein metabolism. Volume 4.

1964 • 17 citations

The elucidation of the structure of atrial natriuretic factor, a new peptide hormone

1987 • 15 citations

Regulation of expression of contractile proteins with cardiac hypertrophy and failure

1996 • 7 citations

1030-11 Ventricular Myocytes in Culture Express Endothelin-1 (ET-1) mRNA but not ET-2 mRNA or ET-3 mRNA in Response to the Hypertrophic Agonists Phenylephrine and ET-1

1995 • 3 citations

Studies on protein turnover in the perfused rat heart

1985 • 1 citations