Mechanism of adenylate kinase: site-directed mutagenesis versus x-ray and NMR

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

[14]Determination and analysis of urea and guanidine hydrochloride denaturation curves

1986 • 2,265 citations

The P-loop — a common motif in ATP- and GTP-binding proteins

1990 • 2,029 citations

Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation

1989 • 881 citations

Conformational stability of globular proteins

1990 • 390 citations

Substrate positions and induced-fit in crystalline adenylate kinase

1977 • 304 citations

Three-dimensional structure of adenyl kinase

1974 • 258 citations

Refined structure of porcine cytosolic adenylate kinase at 2.1 Å resolution

1988 • 243 citations

Synthesis and properties of diastereoisomers of adenosine 5'-(O-1-thiotriphosphate) and adenosine 5'-(O-2-thiotriphosphate)

1976 • 214 citations

Induced-fit movements in adenylate kinases

1990 • 198 citations

Initial Velocity and Equilibrium Kinetics of Myokinase

1968 • 182 citations

The Amino‐Acid Sequence of Porcine Adenylate Kinase from Skeletal Muscle

1974 • 173 citations

NMR studies of the magnesium-ATP binding site of adenylate kinase and of a 45-residue peptide fragment of the enzyme

1985 • 160 citations

Two conformations of crystalline adenylate kinase

1977 • 146 citations

The glycine‐rich loop of adenylate kinase forms a giant anion hole

1986 • 143 citations

Structure of the complex of yeast adenylate kinase with the inhibitor P1,P5-di(adenosine-5′-)pentaphosphate at 2.6 Å resolution

1987 • 131 citations

Induced Fit in Yeast Hexokinase

1970 • 125 citations

Structural relationships in the adenylate kinase family

1986 • 121 citations

Mutations in the nucleotide binding loop of adenylate kinase of Escherichia coli

1988 • 114 citations

Cloning and sequencing of the adenylate kinase gene (adk) ofEscherichia coli

1985 • 110 citations

Site-directed mutants of staphylococcal nuclease. Detection and localization by proton NMR spectroscopy of conformational changes accompanying substitutions for glutamic acid-43

1987 • 92 citations

Structurally and catalytically important residues in the phosphate binding loop of adenylate kinase of Escherichia coli

1990 • 90 citations

Fluorescence and NMR investigations on the ligand binding properties of adenylate kinases

1990 • 87 citations

Enzymatic and 32P nuclear magnetic resonance study of adenylate kinase-catalyzed stereospecific phosphorylation of adenosine 5'-phosphorothioate.

1977 • 84 citations

Human adenylate kinase deficiency associated with hemolytic anemia. A single base substitution affecting solubility and catalytic activity of the cytosolic adenylate kinase.

1989 • 80 citations

PERSPECTIVES IN BIOCHEMISTRY

1940 • 80 citations

Differentiation of nucleotide binding sites and role of metal ion in the adenylate kinase reaction by 31P NMR. Equilibria, interconversion rates, and NMR parameters of bound substrates

1978 • 77 citations

Three-dimensional structure of the complex of guanylate kinase from yeast with its substrate GMP

1990 • 73 citations

Structural and Functional Relationships in the Adenylate Kinase Family

1987 • 71 citations

Structure of the complex of adenylate kinase from Escherichia coli with the inhibitor P1,P5-di(adenosine-5′-)pentaphosphate

1988 • 70 citations

Substrate synergism and the kinetic mechanism of yeast hexokinase

1982 • 68 citations

Affinity labeling of adenylate kinase with adenosine diphosphopyridoxal. Presence of Lys21 in the ATP-binding site.

1987 • 62 citations

Mechanism of adenylate kinase. 6. Are the essential lysines essential?

1990 • 60 citations

Solution structure of the 45-residue magnesium ATP-binding peptide of adenylate kinase as examined by 2-D NMR, FTIR, and CD spectroscopy

1988 • 59 citations

Proton magnetic resonance spectra or porcine muscle adenylate kinase and substrate complexes.

1975 • 57 citations

Mechanism of adenylate kinase. Demonstration of a functional relationship between aspartate 93 and magnesium by site-directed mutagenesis and proton, phosphorus-31, and magnesium-25 NMR

1991 • 53 citations

Isolation and characterization of cDNA for chicken muscle adenylate kinase.

1986 • 53 citations

Studies on adenosine triphosphate transphosphorylases XIV. Equilibrium binding properties of the crystalline rabbit and calf muscle ATP-AMP transphosphorylase (adenylate kinase) and derived peptide fragments

1979 • 53 citations

Three-dimensional structure of the complex between the mitochondrial matrix adenylate kinase and its substrate AMP

1990 • 51 citations

The Role of Metals in Enzyme‐Catalyzed Substitutions at each of the Phosphorus Atoms of ATP

1979 • 49 citations

The switch between two conformations of adenylate kinase

1988 • 49 citations

In vitro mutagenesis studies at the arginine residues of adenylate kinase. A revised binding site for AMP in the x-ray-deduced model

1990 • 48 citations

Nuclear magnetic resonance studies of the nucleotide binding sites of porcine adenylate kinase

1982 • 47 citations

The complete amino acid sequence of adenylate kinase from baker's yeast

1986 • 47 citations

NMR studies of the AMP-binding site and mechanism of adenylate kinase

1987 • 47 citations

Hazards of deducing enzyme structure-activity relationships on the basis of chemical applications of molecular biology

1989 • 44 citations

Substitution of a serine residue for proline-87 reduces catalytic activity and increases susceptibility to proteolysis of Escherichia coli adenylate kinase.

1986 • 39 citations

Adenylate kinases from thermosensitive Escherichia coli strains

1989 • 39 citations

Studies on adenosine triphosphate transphosphorylases

1978 • 39 citations

Low resolution structure of adenylate kinase

1973 • 39 citations

Mechanism of adenylate kinase. Structural and functional demonstration of arginine-138 as a key catalytic residue that cannot be replaced by lysine

1990 • 39 citations

Mechanism of adenylate kinase. Is there a relationship between local substrate dynamics, and local binding energy, and the catalytic mechanism?

1989 • 38 citations

Site-directed Mutagenesis of Pro-17 Located in the Glycine-rich Region of Adenylate Kinase

1989 • 36 citations

High Level Expression of Chicken Muscle Adenylate Kinase in Escherichia coli1

1987 • 36 citations

Mechanism of adenylate kinase. Critical evaluation of the x-ray model and assignment of the AMP site

1990 • 34 citations

Structural and catalytic role of arginine 88 in Escherichia coli adenylate kinase as evidenced by chemical modification and site-directed mutagenesis

1989 • 34 citations

Mechanism of adenylate kinase. Histidine-36 is not directly involved in catalysis, but protects cysteine-25 and stabilizes the tertiary structure

1988 • 34 citations

Assignment of the nucleotide binding sites and the mechanism of substrate inhibition of Escherichia coli adenylate kinase

1991 • 33 citations

Baker's Yeast Adenlate Kinase

1983 • 32 citations

Cloning and characterization of cDNA for mitochondrial GTP:AMP phosphotransferase of bovine liver

1989 • 29 citations

Hazards and their exploitation in the applications of molecular biology to structure-function relationships

1990 • 28 citations

Mechanism of adenylate kinase. 10. Reversing phosphorus stereospecificity by site-directed mutagenesis

1991 • 23 citations

Structural Investigations of the Mg · ATP Complex at the Active Site of Porcine Adenylate Kinase Using Phosphorothioate Analogs and Electron Paramagnetic Resonance of Mn(II) with Chiral ¹⁷)‐Labelled ATP Analogs

1983 • 20 citations

8-Azido-2′-O-dansyl-ATP

1989 • 18 citations

Complexes of Escherichia coli adenylate kinase and nucleotides: proton NMR studies of the nucleotide sites in solution

1990 • 17 citations

The cDNA sequence encoding cytosolic adenylate kinase from baker's yeast (Saccharomyces cerevisiae)

1987 • 17 citations

Nucleotide and AP5A complexes of porcine adenylate kinase: a proton and fluorine-19 NMR study

1989 • 15 citations

Mechanism of adenylate kinase. Does adenosine 5'-triphosphate bind to the adenosine 5'-monophosphate site?

1987 • 14 citations

Inactivation of muscle adenylate kinase by site-specific destruction of tyrosine 95 using potassium ferrate.

1985 • 13 citations

Complexes of yeast adenylate kinase and nucleotides investigated by proton NMR

1991 • 9 citations

Two-dimensional NMR studies of the porcine muscle adenylate kinase

1988 • 8 citations

The role of Leu-190 in the function and stability of adenylate kinase.

1990 • 8 citations

Isolation and characterization of the gene encoding bovine adenylate kinase isozyme 2

1990 • 8 citations

Investigation of the substrate binding and phosphate transfer in adenylate kinase by molecular mechanics.

1988 • 7 citations

Proton-nuclear magnetic resonance studies of the aromatic spin systems of Escherichia coli adenylate kinase

1988 • 6 citations

The binding of ATP and AMP to Escherichia coli adenylate kinase investigated by 1H and 15N NMR spectroscopy

1990 • 5 citations

Identification of valine/leucine/isoleucine and threonine/alanine/glycine proton-spin systems of Escherichia coli adenylate kinase by selective deuteration and selective protonation

1991 • 3 citations

Deleted Work

1955 • 0 citations