The Role of Metals in Enzyme‐Catalyzed Substitutions at each of the Phosphorus Atoms of ATP

The Nature of the Chemical Bond

1939 • 13,296 citations

Catalysis in chemistry and enzymology

1969 • 3,236 citations

Nuclear Magnetic Resonance Spectra of Adenosine Di- and Triphosphate

1962 • 433 citations

The Correlation of Reaction Kinetics and Substrate Binding with the Mechanism of Pyruvate Kinase

1961 • 254 citations

ZINC in DNA polymerases

1971 • 253 citations

A Study of Manganous Complexes by Paramagnetic Resonance Absorption

1954 • 225 citations

Magnetic Resonance Studies of Metal Activation of Enzymic Reactions of Nucleotides and Other Phosphate Substrates^*

1963 • 195 citations

Magnetic Resonance Studies of the Interaction of the Manganous Ion with Bovine Serum Albumin^*

1963 • 195 citations

Escherichia coli Deoxyribonucleic Acid Polymerase I, a Zinc Metalloenzyme

1973 • 190 citations

The Enzymatic Carboxylation of Phosphoenolpyruvate

1968 • 173 citations

Absolute configuration of the diastereomers of adenosine 5'-O-(1-thiotriphosphate): consequences for the stereochemistry of polymerization by DNA-dependent RNA polymerase from Escherichia coli.

1978 • 164 citations

Effects of specific divalent cations on some physical and chemical properties of glutamine synthetase from Escherichia coli. Taut and relaxed enzyme forms

1968 • 158 citations

Preparation and properties of chromium(III)-nucleotide complexes for use in the study of enzyme mechanisms

1973 • 155 citations

Phosphorus Magnetic Resonance Spectra of Adenosine Di- and Triphosphate

1960 • 150 citations

Use of chromium-adenosine triphosphate and lyxose to elucidate the kinetic mechanism and coordination state of the nucleotide substrate for yeast hexokinase

1975 • 141 citations

Phosphorus-31 NMR studies of complexes of adenosine triphosphate, adenosine diphosphate, tripolyphosphate, and pyrophosphate with cobalt(III) ammines

1977 • 137 citations

PYROPHOSPHORYLATION OF RIBOSE 5-PHOSPHATE IN THE ENZYMATIC SYNTHESIS OF 5-PHOSPHORYLRIBOSE 1-PYROPHOSPHATE

1958 • 136 citations

Structural Changes Induced by Substrates and Anions at the Active Site of Creatine Kinase

1972 • 134 citations

Regulation of glutamine synthetase. XI. The nature and implications of a lag phase in the Escherichia coli glutamine synthetase reaction

1968 • 133 citations

Substrate activity of (adenosine triphosphato)tetraamminecobalt(III) with yeast hexokinase and separation of diastereomers using the enzyme

1978 • 125 citations

Magnetic Resonance Investigations of Ternary Complexes of Enzyme–Metal–Substrate

1962 • 118 citations

Alteration of Rat Liver Phosphoenolpyruvate Carboxykinase Activity by L-Tryptophan in Vivo and Metals in Vitro^*

1967 • 117 citations

Kinetic and Magnetic Resonance Studies of Pyruvate Kinase. III. The Enzyme-Metal-Phosphoryl Bridge Complex in the Fluorokinase Reaction^*

1967 • 111 citations

The Mechanism of Escherichia coli Deoxyribonucleic Acid Polymerase I

1972 • 109 citations

Dual divalent cation requirement for activation of pyruvate kinase: essential roles of both enzyme- and nucleotide-bound metal ions

1976 • 94 citations

Regulation and Mechanism of Phosphoribosylpyrophosphate Synthetase

1971 • 90 citations

Magnetic Resonance Investigations of the Metal Complexes Formed in the Manganese-activated Creatine Kinase Reaction

1966 • 86 citations

Experimental evidence for the role of cross-relaxation in proton nuclear magnetic resonance spin lattice relaxation time measurements in proteins

1978 • 86 citations

Conformation of deoxynucleoside triphosphate substrates on DNA polymerase I from Escherichia coli as determined by nuclear magnetic relaxation

1975 • 82 citations

THE MECHANISM OF ENZYMIC PHOSPHATE TRANSFER REACTIONS

1955 • 82 citations

Interaction of pyruvate with pyruvate carboxylase and pyruvate kinase as studied by paramagnetic effects on carbon-13 relaxation rates

1973 • 82 citations

The Inhibition of Acetate, Pyruvate, and 3-Phosphoglycerate Kinase by Chromium Adenosine Triphosphate

1974 • 80 citations

Relaxation Enhancement by Paramagnetic Ion Binding in Deoxyribonucleic Acid Solutions

1961 • 78 citations

Studies on Adenosine Triphosphate Transphosphorylases. IV. Enzyme-Substrate Interactions^*

1962 • 78 citations

Nucleotide Specificity and Conformation of the Active Site of Creatine Kinase

1966 • 77 citations

Differentiation of nucleotide binding sites and role of metal ion in the adenylate kinase reaction by 31P NMR. Equilibria, interconversion rates, and NMR parameters of bound substrates

1978 • 77 citations

Chromium(III)-adenosine triphosphate as a paramagnetic probe to determine intersubstrate distances on pyruvate kinase. Detection of an active enzyme-metal-ATP-metal complex.

1976 • 76 citations

Nuclear Magnetic Resonance Study of Metal-Ion Binding to Adenosine Triphosphate. II. Proton Studies

1965 • 72 citations

Pyruvate Carboxylase

1974 • 71 citations

Studies of the stereochemistry and of the role of metal ions in the mechanism of phosphoribosylpyrophosphate synthetase from Salmonella typhimurium.

1978 • 65 citations

An electron-spin-resonance study of the interaction of manganous ions with enolase and its substrate

1958 • 64 citations

Relaxation spectra of adenosine triphosphate-creatine phosphotransferase

1969 • 61 citations

The Effect of Manganous Ion on the Kinetics and Mechanism of the Yeast Hexokinase Reaction

1964 • 61 citations

Nuclear magnetic relaxation studies of the conformation of adenosine 5'-triphosphate on pyruvate kinase from rabbit muscle.

1976 • 59 citations

Magnetic resonance studies of the conformation of enzyme-bound adenylyl(3' → 5')uridine and adenosine 5'-triphosphate on RNA polymerase from Escherichia coli

1977 • 59 citations

Magnetic resonance studies of substrate and inhibitor binding to porcine muscle adenylate kinase

1973 • 59 citations

Phosphoenolpyruvate Synthetase of Escherichia coli

1970 • 59 citations

31P NMR studies of the arginine kinase reaction. Equilibrium constants and exchange rates at stoichiometric enzyme concentration.

1976 • 56 citations

UDP-glucose pyrophosphorylase. Stereochemical course of the reaction of glucose 1-phosphate with uridine-5'[1-thiotriphosphate].

1978 • 55 citations

Adenosine 5'-O-([gamma-18O]gamma-thio)triphosphate chiral at the gamma-phosphorus: stereochemical consequences of reactions catalyzed by pyruvate kinase, glycerol kinase, and hexokinase.

1978 • 53 citations

Mechanisms of enzymic cleavage of some organic phosphates

1959 • 53 citations

X-ray crystal and molecular structure and absolute configuration of (dihydrogen tripolyphosphato)tetraamminecobalt(III) monohydrate, Co(NH₃)₄H₂P₃O₁₀·H₂O. A model for a metal-nucleoside polyphosphate complex

1978 • 53 citations

Pyruvate Carboxylase from Chicken Liver

1974 • 51 citations

The Interaction of the Lanthanide Ions with Staphylococcal Nuclease

1973 • 49 citations

Magnetic resonance and kinetic studies of the role of the divalent cation activator of RNA polymerase from Escherichia coli

1977 • 46 citations

Arrangement and conformations of substrates at the active site of pyruvate kinase from model building studies based on magnetic resonance data.

1976 • 45 citations

Studies of Manganous Nucleotide Complexes with Uridine Diphosphate-Glucose Pyrophosphorylase, Formyltetrahydrofolate Synthetase, and Creatine Kinase

1972 • 44 citations

Investigations of equilibrium complexes of myoxin subfragment 1 with the manganous ion and adenosine diphosphate using magnetic resonance techniques.

1976 • 44 citations

The role of divalent cations in the mechanism of enzyme catalyzed phosphoryl and nucleotidyl transfer reactions

2007 • 42 citations

Pyruvate Carboxylase

1974 • 42 citations

Magnetic resonance studies of the conformations of enzyme-bound substrates

1977 • 42 citations

The pH Dependence of the Steady State Kinetic Parameters for Staphylococcal Nuclease-catalyzed Hydrolysis of Deoxythymidine-3′-phosphate-5′-p-nitrophenylphosphate in H2O and D2O

1973 • 41 citations

Magnetic resonance studies of the manganese guanosine di- and triphosphate complexes with elongation factor Tu.

1977 • 40 citations

Formyltetrahydrofolate Synthetase

1967 • 40 citations

Three-dimensional structure of cat muscle pyruvate kinase at 3·1 Å resolution

1977 • 39 citations

Kinetic and Magnetic Resonance Studies of the Mechanism of d-Xylose Isomerase

1972 • 35 citations

Magnetic resonance and kinetic studies of the mechanism of membrane‐bound sodium and potassium ION‐activated adenosine triphosphatase

1975 • 35 citations

Magnetic resonance and kinetic studies of pyruvate phosphate dikinase. Interaction of oxalate with the phosphorylated form of the enzyme

1975 • 35 citations

Magnetic resonance studies of the interaction of Co2+ and phosphoenolpyruvate with pyruvate kinase.

1975 • 35 citations

The Magnesium Ion (Mg2+) Activation of Sheep Kidney Pyruvate Carboxylase

1972 • 34 citations

Magnetic Resonance and Kinetic Studies Related to the Manganese Activation of the Adenylate Kinase Reaction

1968 • 34 citations

Proton magnetic relaxation studies of the interaction of D-xylose and xylitol with D-xylose isomerase. Characterization of metal-enzyme-substrate interactions

1975 • 31 citations

Electron paramagnetic resonance and water proton relaxation rate studies of formyltetrahydrofolate synthetase-manganous ion complexes. Evidence for involvement of substrates in the promotion of a catalytically competent active site.

1975 • 30 citations

Determination of metal-metal distances in E. coli glutamine synthetase by EPR

1977 • 30 citations

Oxygen-18 studies of the mechanism of pyrophosphoryl group transfer catalyzed by phosphoribosylpyrophosphate synthetase

1975 • 29 citations

The stereochemical course of acetate activation by yeast acetyl-CoA synthetase.

1978 • 28 citations

Nuclear magnetic resonance studies of inorganic phosphate binding to yeast inorganic pyrophosphatase

1978 • 28 citations

A novel nuclear relaxation approach for estimating distance between enzyme- and nucleotide-bound metal ions at the catalytic site of pyruvate kinase.

1977 • 27 citations

Magnetic resonance and kinetic studies of initiator-substrate distances on RNA polymerase from Escherichia coli

1978 • 23 citations

Arrangement of the phosphate- and metal-binding subsites of phospholucomutase. Intersubsite distance by means of nuclear magnetic resonance measurements

1973 • 22 citations

Role of bivalent cations in the phosphoglucomutase system. IV. Study of the Mn2+ binding site by means of nuclear relaxation measurements on water protons

1970 • 21 citations

NUCLEAR RELAXATION STUDIES OF THE ROLE OF THE DIVALENT CATION IN THE MECHANISM OF PYRUVATE KINASE AND ENOLASE: INNER SPHERE AND SECOND SPHERE COMPLEXES *

1973 • 20 citations

Phosphorus nuclear magnetic resonance studies of phosphoglucomutase and its metal ion complexes

1977 • 18 citations

Magnetic resonance studies on manganese-nucleotide complexes of phosphoglycerate kinase

1977 • 16 citations