Mechanism of adenylate kinase. Demonstration of a functional relationship between aspartate 93 and magnesium by site-directed mutagenesis and proton, phosphorus-31, and magnesium-25 NMR

[14]Determination and analysis of urea and guanidine hydrochloride denaturation curves

1986 • 2,265 citations

Time-resolved X-ray crystallographic study of the conformational change in Ha-Ras p21 protein on GTP hydrolysis

1990 • 489 citations

Observation of histidine residues in proteins by nuclear magnetic resonance spectroscopy

1975 • 416 citations

The use of phosphorothioate-modified DNA in restriction enzyme reactions to prepare nicked DNA

1985 • 247 citations

Refined structure of porcine cytosolic adenylate kinase at 2.1 Å resolution

1988 • 243 citations

Initial Velocity and Equilibrium Kinetics of Myokinase

1968 • 182 citations

NMR studies of the magnesium-ATP binding site of adenylate kinase and of a 45-residue peptide fragment of the enzyme

1985 • 160 citations

Structure of the complex of yeast adenylate kinase with the inhibitor P1,P5-di(adenosine-5′-)pentaphosphate at 2.6 Å resolution

1987 • 131 citations

Aspects of Enzyme Mechanisms Studied by Nuclear Spin Relaxation Induced by Paramagnetic Probes

1970 • 124 citations

ADENOSINE TRIPHOSPHATE-ADENOSINE MONOPHOSPHATE TRANSPHOSPHORYLASE

1958 • 112 citations

Investigations of substrate specificity and reaction mechanism of several kinases using chromium(III) adenosine 5'-triphosphate and chromium(III) adenosine 5'-diphosphate

1980 • 112 citations

Fluorescence and NMR investigations on the ligand binding properties of adenylate kinases

1990 • 87 citations

Is the binding of magnesium(II) to calmodulin significant? An investigation by magnesium-25 nuclear magnetic resonance

1987 • 85 citations

Structural and Functional Relationships in the Adenylate Kinase Family

1987 • 71 citations

Mechanism of adenylate kinase. 6. Are the essential lysines essential?

1990 • 60 citations

Proton magnetic resonance spectra or porcine muscle adenylate kinase and substrate complexes.

1975 • 57 citations

The Role of Metals in Enzyme‐Catalyzed Substitutions at each of the Phosphorus Atoms of ATP

1979 • 49 citations

In vitro mutagenesis studies at the arginine residues of adenylate kinase. A revised binding site for AMP in the x-ray-deduced model

1990 • 48 citations

Some properties of the phosphorothioate analogs of adenosine triphosphate as substrates of enzymic reactions

1982 • 48 citations

Nuclear magnetic resonance studies of the nucleotide binding sites of porcine adenylate kinase

1982 • 47 citations

Mechanism of adenylate kinase. Structural and functional demonstration of arginine-138 as a key catalytic residue that cannot be replaced by lysine

1990 • 39 citations

Mechanism of adenylate kinase. Is there a relationship between local substrate dynamics, and local binding energy, and the catalytic mechanism?

1989 • 38 citations

High Level Expression of Chicken Muscle Adenylate Kinase in Escherichia coli1

1987 • 36 citations

Mechanism of adenylate kinase. Critical evaluation of the x-ray model and assignment of the AMP site

1990 • 34 citations

Mechanism of adenylate kinase. Histidine-36 is not directly involved in catalysis, but protects cysteine-25 and stabilizes the tertiary structure

1988 • 34 citations

Stereoelectronic effects at carboxylate: a syn-oriented model for the histidine-aspartate couple in enzymes

1988 • 29 citations

Asymmetric binding of the inhibitor di(adenosine-5′) pentaphosphate (Ap ₅ A) to adenylate kinase

1977 • 26 citations

[15] Phosphorus-31 nuclear magnetic resonance of enzyme complexes: Bound ligand structure, dynamics, and environment

1989 • 22 citations

Phosphorus-31 NMR studies of the structure of cation-nucleotide complexes bound to porcine muscle adenylate kinase

1988 • 21 citations

[16] Ligand-protein interactions via nuclear magnetic resonance of quadrupolar nuclei

1989 • 10 citations