VP-16-induced nucleotide pool changes and poly(ADP-ribose) synthesis: The role of VP-16 in interphase death

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

(ADP-ribose)n participates in DNA excision repair

1980 • 1,112 citations

Poly ADP-ribose and ADP-ribosylation of proteins

1976 • 572 citations

Cleavage of DNA by mammalian DNA topoisomerase II.

1983 • 539 citations

Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II.

1984 • 491 citations

Role of topoisomerase II in mediating epipodophyllotoxin-induced DNA cleavage.

1984 • 463 citations

Fluorometric method for rapid detection of DNA strand breaks in human white blood cells produced by low doses of radiation.

1981 • 448 citations

Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes.

1985 • 397 citations

An improved cycling assay for nicotinamide adenine dinucleotide

1973 • 382 citations

DNA strand breaks, NAD metabolism, and programmed cell death

1986 • 303 citations

Inhibitors of Poly(Adenosine Diphosphate-Ribose) Synthesis: Effect on Other Metabolic Processes

1984 • 241 citations

Radiation-induced Interphase Death of Rat Thymocytes is Internally Programmed (Apoptosis)

1988 • 239 citations

Association of Poly(Adenosine Diphosphoribose) Synthesis with DNA Damage and Repair in Normal Human Lymphocytes

1979 • 222 citations

Cytoskeletal and morphologic impact of cellular oxidant injury.

1986 • 190 citations

Comparison of cytotoxicity and DNA breakage activity of congeners of podophyllotoxin including VP16-213 and VM26: a quantitative structure-activity relationship

1984 • 188 citations

Proliferation dependence of topoisomerase II-mediated drug action

1986 • 170 citations

Defective poly(adenosine diphosphoribose) synthesis in Xeroderma pigmentosum

1980 • 145 citations

Topoisomerase-specific drug sensitivity in relation to cell cycle progression.

1987 • 144 citations

Relationship between the intracellular effects of camptothecin and the inhibition of DNA topoisomerase I in cultured L1210 cells.

1987 • 141 citations

Differences in the regulation by poly(ADP-ribose) of repair of DNA damage from alkylating agents and ultraviolet light according to cell type.

1983 • 116 citations

Adenosine phosphorylase-mediated nucleoside toxicity

1982 • 96 citations

Modifications of sphingomyelin and phosphatidylcholine metabolism by tricyclic antidepressants and phenothiazines

1986 • 91 citations

Inhibition of protein synthesis reduces the cytotoxicity of 4'-(9-acridinylamino) methane-sulfon-m-anisidide without affecting DNA breakage and DNA topoisomerase ii in a murine mastocytoma cell line

1989 • 53 citations

Characterization of VP-16-induced DNA damage in isolated nuclei from L1210 cells

1984 • 50 citations

Topoisomerase inhibitors induce irreversible fragmentation of replicated DNA in concanavalin A stimulated splenocytes

1988 • 50 citations

Role of nicotinamide adenine dinucleotide and adenosine triphosphate in glucocorticoid-induced cytotoxicity in susceptible lymphoid cells.

1987 • 31 citations

Formation and resealing of intercalator-induced DNA strand breaks in permeabilized L1210 cells without the stimulated synthesis of poly(ADP-ribose).

1982 • 27 citations

Cancer chemotherapy: new strategies for success.

1986 • 25 citations

Prevention of adriamycin-induced interphase death by 3-aminobenzamide and nicotinamide in a human promyelocytic leukemia cell line

1987 • 19 citations

Characterization of an adenosine deaminase-deficient human histiocytic lymphoma cell line (DHL-9) and selection of mutants deficient in adenosir kinase and deoxycytidine kinase.

1983 • 15 citations

Effect of hyperthermia and doxorubicin on nucleoid sedimentation and poly (ADP-ribose) Polymerase activity in L1210 cells

1988 • 6 citations