Immobilization of glycosylphosphatidylinositol-anchored proteins inhibits T cell growth but not function

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface

1992 • 2,905 citations

Xenogeneic Monoclonal Antibodies to Mouse Lymphoid Differentiation Antigens*

1979 • 1,989 citations

Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule.

1983 • 1,307 citations

Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

1988 • 1,086 citations

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

1989 • 1,010 citations

Membrane Compartmentation Is Required for Efficient T Cell Activation

1998 • 925 citations

GPI-Anchored Cell-Surface Molecules Complexed to Protein Tyrosine Kinases

1991 • 848 citations

LAT Palmitoylation

1998 • 837 citations

Caveolae, DIGs, and the dynamics of sphingolipid—cholesterol microdomains

1997 • 783 citations

Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors.

1989 • 778 citations

Signaling Through the Hematopoietic Cytokine Receptors

1995 • 617 citations

The Cloning of PIG-A, a Component in the Early Step of GPI-Anchor Biosynthesis

1993 • 528 citations

Direct activation of the serine/threonine kinase activity of raf-1 through tyrosine phosphorylation by the PDGF β-receptor

1989 • 513 citations

The structure and ligand interactions of CD2: implications for T-cell function

1996 • 397 citations

Urokinase plasminogen activator receptor, beta 2-integrins, and Src-kinases within a single receptor complex of human monocytes.

1995 • 355 citations

The proteins encoded by the VpreB and lambda 5 pre-B cell-specific genes can associate with each other and with mu heavy chain.

1990 • 352 citations

Identification and initial characterization of a rat monoclonal antibody reactive with the murine interleukin 2 receptor-ligand complex.

1983 • 348 citations

A rat anti-mouse T4 monoclonal antibody (H129.19) inhibits the proliferation of Ia-reactive T cell clones and delineates two phenotypically distinct (T4+, Lyt-2,3-, and T4-, Lyt-2,3+) subsets among anti-Ia cytolytic T cell clones.

1984 • 308 citations

Somatic Mutations in Paroxysmal Nocturnal Hemoglobinuria: A Blessing in Disguise?

1997 • 305 citations

T cell-activating properties of an anti-Thy-1 monoclonal antibody. Possible analogy to OKT3/Leu-4.

1984 • 302 citations

Signal transduction through decay-accelerating factor. Interaction of glycosyl-phosphatidylinositol anchor and protein tyrosine kinases p56lck and p59fyn 1.

1992 • 286 citations

Engagement of GPI-Linked CD48 Contributes to TCR Signals and Cytoskeletal Reorganization

1998 • 278 citations

Palmitylation of an amino-terminal cysteine motif of protein tyrosine kinases p56lck and p59fyn mediates interaction with glycosyl-phosphatidylinositol-anchored proteins.

1993 • 259 citations

T Cell Activation Induces Rapid Tyrosine Phosphorylation of a Limited Number of Cellular Substrates

1989 • 258 citations

Glycosylphosphatidylinositol-anchor-deficient mice: implications for clonal dominance of mutant cells in paroxysmal nocturnal hemoglobinuria

1996 • 238 citations

Role of Ly-6 in lymphocyte activation. II. Induction of T cell activation by monoclonal anti-Ly-6 antibodies.

1986 • 191 citations

A glycophospholipid anchor is required for Qa-2-mediated T cell activation

1989 • 169 citations

Integrins as promiscuous signal transduction devices

1996 • 165 citations

Antiproliferative action of interferon-α requires components of T-cell-receptor signalling

1997 • 157 citations

Decay-accelerating factor functions as a signal transducing molecule for human T cells.

1988 • 154 citations

CD59 functions as a signal-transducing molecule for human T cell activation.

1991 • 153 citations

Association of tyrosine kinase p56lck with CD4 inhibits the induction of growth through the αβ T-cell receptor

1992 • 146 citations

Antibodies to 5'-nucleotidase (CD73), a glycosyl-phosphatidylinositol-anchored protein, cause human peripheral blood T cells to proliferate.

1989 • 128 citations

Thymocytes in Thy-1−/− mice show augmented TCR signaling and impaired differentiation

1997 • 123 citations

Altered Proliferative Response by T Lymphocytes of Ly-6A (Sca-1) Null Mice

1997 • 120 citations

Mammals have multiple genes for individual ribosomal proteins

1981 • 113 citations

TAP transcription and phosphatidylinositol linkage mutants are defective in activation through the T cell receptor

1988 • 112 citations

Functional competence of T cells in the absence of glycosylphosphatidylinositol-anchored proteins caused by T cell-specific disruption of thePig-agene

1998 • 111 citations

The association between glycosylphosphatidylinositol-anchored proteins and heterotrimeric G protein alpha subunits in lymphocytes.

1996 • 107 citations

The glycosyl phosphatidylinositol anchor is critical for Ly-6A/E-mediated T cell activation.

1991 • 99 citations

The murine interleukin 2 receptor. Irreversible cross-linking of radiolabeled interleukin 2 to high affinity interleukin 2 receptors reveals a noncovalently associated subunit.

1987 • 91 citations

Expression and function of the gamma c subunit of the IL-2, IL-4, and IL-7 receptors. Distinct interaction of gamma c in the IL-4 receptor.

1995 • 73 citations

Interaction of Fcγ receptor type IIIB with complement receptor type 3 in fibroblast transfectants: Evidence from lateral diffusion and resonance energy transfer studies

1995 • 70 citations

Role of Ly-6 in lymphocyte activation. I. Characterization of a monoclonal antibody to a nonpolymorphic Ly-6 specificity.

1986 • 69 citations

Modulation of TCR-mediated signaling pathway by thymic shared antigen-1 (TSA-1)/stem cell antigen-2 (Sca-2).

1995 • 59 citations

CD73 expression and fyn-dependent signaling on murine lymphocytes

1998 • 58 citations

Syngeneic bone marrow transplantation without conditioning in a patient with paroxysmal nocturnal hemoglobinuria: in vivo evidence that the mutant stem cells have a survival advantage

1996 • 58 citations

Anti-Qa-2-induced T cell activation. The parameters of activation, the definition of mitogenic and nonmitogenic antibodies, and the differential effects on CD4+ vs CD8+ T cells.

1989 • 46 citations

Phosphatidylinositol-based glycolipid-anchored proteins enhance proximal TCR signaling events.

1997 • 44 citations

sgp-60, a signal-transducing glycoprotein concerned with T cell activation through the T cell receptor/CD3 complex.

1990 • 35 citations

Physical Association of CD4 and CD45 in Primary, Resting CD4+T Cells

1997 • 35 citations

Epitope clusters of Qa-2 antigens defined by a panel of new monoclonal antibodies.

1989 • 35 citations

Phenotypic and functional analysis of lymphocytes in paroxysmal nocturnal hemoglobinuria

1995 • 32 citations

[61] Purification of rat monoclonal antibodies

1986 • 27 citations

Multiple glycosylphosphatidylinositol-anchored Ly-6 molecules and transmembrane Ly-6E mediate inhibition of IL-2 production.

1994 • 27 citations

Down-regulation of IL-2 production by activation of T cells through Ly-6A/E.

1990 • 27 citations

Immobilized antibodies to CD45 induce rapid morphologic changes and increased tyrosine phosphorylation of p56lck-associated proteins in T cells.

1995 • 27 citations

Identification and characterization of an inherited mutation of PIG‐A in a patient with paroxysmal nocturnal haemoglobinuria

1996 • 20 citations

Costimulatory signal provided by a B-lymphoblastoid cell line and its Ia-negative variant.

1989 • 17 citations

Role of Ly-6A/E and T cell receptor-zeta for IL-2 production. Phosphatidylinositol-anchored Ly-6A/E antagonizes T cell receptor-mediated IL-2 production by a zeta-independent pathway.

1992 • 16 citations

Glycosylphosphatidylinositol (GPI)-anchored surface antigens in the allogeneic activation of T cells

1995 • 14 citations

Selection of internalization‐deficient cells by interleukin‐2‐Pseudomonas exotoxin chimeric protein: the cytoplasmic domain of the interleukin‐2 receptor β chain does not contribute to internalization of interleukin‐2

1993 • 11 citations

Isolation of high‐affinity murine interleukin 2 receptors as detergent‐resistant membrane complexes

1990 • 9 citations

Signaling by a New Anti-Thy 1 Monoclonal Antibody Inhibits T Cell Proliferation and Interferes with T-Cell-Mediated Induction of Costimulatory Molecule B7-2

1995 • 8 citations

GPI-anchored molecules enhance proximal TCR signalling events

1997 • 4 citations