Diagnosis and management of inherited and acquired thrombophilias.

Mutation in blood coagulation factor V associated with resistance to activated protein C

1994 • 3,871 citations

A Quantitative Assessment of Plasma Homocysteine as a Risk Factor for Vascular Disease

1995 • 3,645 citations

A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis

1996 • 3,124 citations

Hyperhomocysteinemia: An Independent Risk Factor for Vascular Disease

1991 • 2,191 citations

Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C.

1993 • 1,997 citations

Vitamin Status and Intake as Primary Determinants of Homocysteinemia in an Elderly Population

1993 • 1,920 citations

A Prospective Study of Plasma Homocyst(e)ine and Risk of Myocardial Infarction in US Physicians

1992 • 1,686 citations

Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H).

1990 • 1,618 citations

The Management of Thrombosis in the Antiphospholipid-Antibody Syndrome

1995 • 1,467 citations

Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study

1993 • 1,283 citations

Deficiency of protein C in congenital thrombotic disease.

1981 • 1,260 citations

Association between Plasma Homocysteine Concentrations and Extracranial Carotid-Artery Stenosis

1995 • 1,244 citations

Resistance to Activated Protein C as a Basis for Venous Thrombosis

1994 • 1,148 citations

Increased risk of venous thrombosis in oral-contraceptive users who are carriers of factor V Leiden mutation

1994 • 1,065 citations

Mutation in the Gene Coding for Coagulation Factor V and the Risk of Myocardial Infarction, Stroke, and Venous Thrombosis in Apparently Healthy Men

1995 • 1,060 citations

Disorders of transsulfuration

1989 • 1,053 citations

Inherited Antithrombin Deficiency Causing Thrombophilia

1965 • 1,040 citations

Hyperhomocysteinemia as a Risk Factor for Deep-Vein Thrombosis

1996 • 1,034 citations

Homocystine-induced arteriosclerosis. The role of endothelial cell injury and platelet response in its genesis.

1976 • 933 citations

Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen.

1993 • 865 citations

Major bleeding in outpatients treated with warfarin: incidence and prediction by factors known at the start of outpatient therapy

1989 • 776 citations

Antiphospholipid Thrombosis: Clinical Course after the First Thrombotic Event in 70 Patients

1992 • 702 citations

Homocysteine and vascular disease

1996 • 694 citations

Risk Factors for Complications of Chronic Anticoagulation: A Multicenter Study

1993 • 682 citations

Management of Deep Vein Thrombosis and Pulmonary Embolism

1996 • 646 citations

Thermolabile methylenetetrahydrofolate reductase: an inherited risk factor for coronary artery disease.

1991 • 615 citations

Repeated fetal losses associated with antiphospholipid antibodies: A collaborative randomized trial comparing prednisone with low-dose heparin treatment

1992 • 594 citations

ARTERIAL THROMBOSIS, INTRAUTERINE DEATH AND "LUPUS" ANTICOAGULANT: DETECTION OF IMMUNOGLOBULIN INTERFERING WITH PROSTACYCLIN FORMATION

1981 • 558 citations

Plasma protein S deficiency in familial thrombotic disease

1984 • 516 citations

Prevalence of hyperhomocyst(e)inemia in patients with peripheral arterial occlusive disease.

1989 • 510 citations

Recurrent Venous Thromboembolism in Patients with a Partial Deficiency of Protein S

1984 • 507 citations

A hemorrhagic disorder caused by circulating anticoagulant in patients with disseminated lupus erythematosus

1952 • 499 citations

Deficiencies of Coagulation-Inhibiting and Fibrinolytic Proteins in Outpatients with Deep-Vein Thrombosis

1990 • 456 citations

Association of idiopathic venous thromboembolism with single point-mutation at Arg506 of factor V

1994 • 446 citations

Inherited thrombophilia: pathogenesis, clinical syndromes, and management [see comments]

1996 • 438 citations

Anticoagulant protein C pathway defective in majority of thrombophilic patients [see comments]

1993 • 411 citations

Antithrombin III Deficiency and Thromboembolism

1981 • 398 citations

Factor V Leiden (Resistance to Activated Protein C) Increases the Risk of Myocardial Infarction in Young Women

1997 • 383 citations

Is hyperhomocysteinaemia a risk factor for recurrent venous thrombosis?

1995 • 374 citations

Prevalence of antithrombin deficiency in the healthy population

1994 • 363 citations

ANTIBODIES TO CARDIOLIPIN IN YOUNG SURVIVORS OF MYOCARDIAL INFARCTION: AN ASSOCIATION WITH RECURRENT CARDIOVASCULAR EVENTS

1986 • 361 citations

Increased risk of venous thrombosis in carriers of hereditary protein C deficiency defect

1993 • 354 citations

Anticoagulant protein C pathway defective in majority of thrombophilic patients [see comments]

1993 • 337 citations

Acceleration of thrombin-antithrombin complex formation in rat hindquarters via heparinlike molecules bound to the endothelium.

1984 • 335 citations

Metabolic evidence that deficiencies of vitamin B−12 (cobalamin), folate, and vitamin B−6 occur commonly in elderly people

1993 • 332 citations

Prevalence of Protein C Deficiency in the Healthy Population

1995 • 328 citations

Homocysteine-induced modulation of tissue plasminogen activator binding to its endothelial cell membrane receptor.

1993 • 320 citations

Homocysteine, a risk factor for premature vascular disease and thrombosis, induces tissue factor activity in endothelial cells.

1993 • 314 citations

Thrombosis and Pregnancy in Congenital Deficiencies in AT III, Protein C or Protein S: Study of 78 Women

1990 • 283 citations

Bleeding and Thromboembolism During Anticoagulant Therapy:A Population-Based Study in Rochester, Minnesota

1995 • 281 citations

Comparative trial of prednisone plus aspirin versus aspirin alone in the treatment of anticardiolipin antibody-positive obstetric patients

1993 • 278 citations

Prevalence, Follow-Up and Clinical Significance of the Anticardiolipin Antibodies in Normal Subjects

1994 • 277 citations

Anticardiolipin antibodies are an independent risk factor for first ischemic stroke

1993 • 268 citations

Genetic Polymorphism of 5,10-Methylenetetrahydrofolate Reductase (MTHFR) as a Risk Factor for Coronary Artery Disease

1997 • 264 citations

The 20210 A Allele of the Prothrombin Gene Is a Common Risk Factor among Swedish Outpatients with Verified Deep Venous Thrombosis

1997 • 255 citations

The Relationship Between Lupus Anticoagulants and Antibodies to Phospholipid

1988 • 254 citations

High prevalence of hyperhomocyst(e)inemia in patients with juvenile venous thrombosis.

1994 • 251 citations

Antiphospholipid antibodies and cerebral ischemia in young people

1990 • 250 citations

Homocysteinemia: Association of a metabolic disorder with vascular disease and thrombosis

1993 • 249 citations

The effect of a subnormal vitamin B-6 status on homocysteine metabolism.

1996 • 245 citations

Homocysteine, a thrombogenic agent, suppresses anticoagulant heparan sulfate expression in cultured porcine aortic endothelial cells.

1993 • 243 citations

Patients with antiphospholipid antibodies and venous thrombosis should receive long term anticoagulant treatment.

1993 • 241 citations

The Frequency of Type I Heterozygous Protein S and Protein C Deficiency in 141 Unrelated Young Patients with Venous Thrombosis

1988 • 227 citations

Immune mediated mechanism for thrombosis: antiphospholipid antibody binding to platelet membranes.

1988 • 226 citations

Predisposing factors to thrombosis in systemic lupus erythematosus: possible relation to endothelial cell damage.

1979 • 218 citations

Inhibition of activated protein C and its cofactor protein S by antiphospholipid antibodies

1990 • 216 citations

Effect of Lupus Anticoagulant on Antithrombogenic Properties of Endothelial Cells - Inhibition of Thrombomodulin-Dependent Protein C Activation

1988 • 194 citations

Thrombosis in Antithrombin-III-deficient Persons

1992 • 178 citations

Impaired catalytic function of activated protein C: a new in vitro manifestation of lupus anticoagulant

1989 • 178 citations

Vitamins as Homocysteine-Lowering Agents

1996 • 177 citations

Heparin therapy for pregnant women with lupus anticoagulant or anticardiolipin antibodies

1991 • 170 citations

The Use of a Functional and Immunologic Assay for Plasma Protein C in the Study of the Heterogeneity of Congenital Protein C Deficiency

1984 • 169 citations

Low functional and high antigenic antithrombin iii level in a patient with the lupus anticoagulant and recurrent thrombosis

1981 • 168 citations

Inherited predisposition to thrombosis

1993 • 166 citations

Anticardiolipin antibodies and lupus anticoagulants comprise separate antibody subgroups with different phospholipid binding characteristics

1989 • 159 citations

Beta 2-glycoprotein I is a requirement for anticardiolipin antibodies binding to activated platelets: differences with lupus anticoagulants

1993 • 151 citations

Hereditary deficiency of antithrombin III, protein C and protein S: prevalence in patients with a history of venous thrombosis and criteria for rational patient screening.

1992 • 151 citations

Prekallikrein Inhibition Associated with the Lupus Anticoagulant: A Mechanism of Thrombosis

1982 • 146 citations

Age-Specific Incidence Rates of Venous Thromboembolism among Heterozygous Carriers of Factor V Leiden Mutation

1997 • 138 citations

Lupus anticoagulant and pregnancy

1985 • 134 citations

Incidence and clinical characteristics of hereditary disorders associated with venous thrombosis

1991 • 127 citations

The spectrum of genetic defects in a panel of 40 Dutch families with symptomatic protein C deficiency type I: heterogeneity and founder effects

1991 • 126 citations

Variability of Thrombosis among Homozygous Siblings with Resistance to Activated Protein C Due to an Arg-to-Gln Mutation in the Gene for Factor V

1994 • 125 citations

Antithrombin III Mutation Database: First Update

1993 • 124 citations

A Critical Review of the Evidence Supporting a Relationship Between Impaired Fibrinolytic Activity and Venous Thromboembolism

1991 • 122 citations

Thromboembolic Disease – Critical Evaluation of Laboratory Investigation

1992 • 119 citations

Intravenous immunoglobulin therapy for the antiphospholipid syndrome in pregnancy

1995 • 118 citations

A Prospective Epidemiological Study on the Occurrence of Antiphospholipid Antibody: The Montpellier Antiphospholipid (MAP) Study

1994 • 105 citations

Activated Protein C Resistance: Molecular Mechanisms

1995 • 88 citations

Deficiencies of coagulation-inhibiting and fibrinolytic proteins in outpatients with deep-vein thrombosis

1991 • 87 citations

Effects of Homocysteine and Related Compounds on Prostacyclin Production by Cultured Human Vascular Endothelial Cells

1993 • 84 citations

Activated Protein C Increases Fibrin Clot Lysis by Neutralization of Plasminogen Activator Inhibitor No Evidence for a Cofactor Role of Protein S

1988 • 69 citations

Antithrombin III: Critical Review of Assay Methods. Significance of Variations in Health and Disease

1977 • 61 citations

Hypercoagulability and Thrombosis

1992 • 61 citations

Guidelines on the investigation and management of thrombophilia. The British Committee for Standards in Haematology.

1990 • 58 citations

Hereditary thrombophilia: identification of nonsense and missense mutations in the protein C gene.

1987 • 57 citations

Molecular Characterization of a Type I Quantitative Factor V Deficiency in a Thrombosis Patient that Is “Pseudo Homozygous” for Activated Protein C Resistance

1997 • 55 citations

Normal fetal growth in women with antiphospholipid syndrome treated with high‐dose intravenous immunoglobulin (IVIG)

1995 • 54 citations

Congenital thrombophilia among patients with venous thromboembolism

1992 • 53 citations

Anticardiolipin Antibodies and Thrombosis

1992 • 52 citations

A Review of Mutations Causing Deficiencies of Antithrombin, Protein C and Protein S

1995 • 50 citations

Value of immunologic testing in stroke patients. A prospective multicenter study.

1994 • 47 citations

Antithrombin III: Critical Review of Assay Methods

1978 • 41 citations

Antiphospholipid thrombosis syndromes: etiology, pathophysiology, diagnosis and management.

1997 • 41 citations

Hypercoagulability and thrombosis

1994 • 38 citations

Acquired Circulating Anticoagulants

1992 • 37 citations

Thromboembolism. A complication of weekly chemotherapy in the treatment of non-Hodgkin's lymphoma

1990 • 33 citations

The automated modified Russell viper venom time test for the lupus anticoagulant.

1991 • 32 citations

Coagulation Abnormalities in Patients With Precocious Coronary Artery Thrombosis and Patients Failing Coronary Artery Bypass Grafting and Percutaneous Transcoronary Angioplasty

1993 • 28 citations

Antiphospholipid Antibodies in Coronary Artery Disease: A Review

1994 • 27 citations

Guidelines for the management of thrombophilia. Department of Haematology, The Royal London Hospital, Whitechapel, London, UK.

1996 • 22 citations

Therapeutic considerations for stroke patients with antiphospholipid antibodies.

1992 • 20 citations

Blood Protein Defects Associated with Thrombosis: Laboratory Assessment

1995 • 17 citations

A case of IgM antibodies which inhibit the contact activation of blood coagulation

1978 • 16 citations

Antiphospholipid antibody syndrome and recurrent fetal loss

1991 • 8 citations

[Prednisolone and aspirin therapy for habitual abortion associated with anti-cardiolipin antibody].

1992 • 4 citations