Blood Protein Defects Associated with Thrombosis: Laboratory Assessment

The Metabolic Basis of Inherited Disease

1990 • 4,327 citations

Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C.

1993 • 1,997 citations

Deficiency of protein C in congenital thrombotic disease.

1981 • 1,260 citations

Inherited Antithrombin Deficiency Causing Thrombophilia

1965 • 1,040 citations

A new vitamin K-dependent protein. Purification from bovine plasma and preliminary characterization.

1976 • 634 citations

Familial protein S deficiency is associated with recurrent thrombosis.

1984 • 614 citations

A comparison of human prothrombin, factor IX (Christmas factor), factor X (Stuart factor), and protein S

1977 • 582 citations

Plasma protein S deficiency in familial thrombotic disease

1984 • 516 citations

Prevalence of hyperhomocyst(e)inemia in patients with peripheral arterial occlusive disease.

1989 • 510 citations

Regulation of activated protein C by a new protein. A possible function for bovine protein S.

1980 • 460 citations

Deficiencies of Coagulation-Inhibiting and Fibrinolytic Proteins in Outpatients with Deep-Vein Thrombosis

1990 • 456 citations

Actions and Interactions of Antithrombin and Heparin

1975 • 449 citations

Homozygous Protein C Deficiency Manifested by Massive Venous Thrombosis in the Newborn

1984 • 444 citations

Activation of heparin cofactor II by dermatan sulfate.

1983 • 439 citations

Heparin cofactor II. Purification and properties of a heparin-dependent inhibitor of thrombin in human plasma.

1982 • 427 citations

Purification of antithrombin III by affinity chromatography

1974 • 426 citations

Anticoagulant activity of heparin: Separation of high‐activity and low‐activity heparin species by affinity chromatography on immobilized antithrombin

1976 • 420 citations

Congenital Protein C Deficiency and Venous Thromboembolism

1983 • 408 citations

Antithrombin III Deficiency and Thromboembolism

1981 • 398 citations

Hereditary Protein S Deficiency: Clinical Manifestations

1987 • 391 citations

Inherited resistance to activated protein C iscorrected by anticoagulant cofactor activity found to be a property of factorV.

1994 • 359 citations

Functional and immunologic protein S levels are decreased during pregnancy

1986 • 347 citations

Heparin cofactor activity measured with an amidolytic method

1975 • 341 citations

Acquired antithrombin III deficiency and thrombosis in the nephrotic syndrome

1978 • 320 citations

Changes in the Blood Coagulation System Associated with Septicemia

1968 • 318 citations

Increased Plasminogen Activator Inhibitor Activity in Non Insulin Dependent Diabetic Patients – Relationship with Plasma Insulin

1989 • 296 citations

Urokinase-plasminogen activator, a marker for aggressive breast carcinomas. Preliminary report

1988 • 294 citations

An abnormal plasma distribution of protein S occurs in functional protein S deficiency

1986 • 289 citations

Protein C Deficiency in a Dutch Family with Thrombotic Disease

1982 • 287 citations

Abnormal Plasminogen

1978 • 259 citations

Homocysteinemia: Association of a metabolic disorder with vascular disease and thrombosis

1993 • 249 citations

THE INHIBITION OF BLOOD CLOTTING: AN UNIDENTIFIED SUBSTANCE WHICH ACTS IN CONJUNCTION WITH HEPARIN TO PREVENT THE CONVERSION OF PROTHROMBIN INTO THROMBIN

1939 • 235 citations

The Frequency of Type I Heterozygous Protein S and Protein C Deficiency in 141 Unrelated Young Patients with Venous Thrombosis

1988 • 227 citations

Fibrinogen Detroit—a Molecular Defect in the N-terminal Disulphide Knot of Human Fibrinogen?

1968 • 225 citations

Acquired deficiencies of protein S. Protein S activity during oral anticoagulation, in liver disease, and in disseminated intravascular coagulation.

1988 • 210 citations

Neonatal purpura fulminans: a genetic disorder related to the absence of protein C in blood

1985 • 204 citations

Inhibition of activated factor XII by antithrombin-heparin cofactor.

1976 • 200 citations

Thrombosis or Myocardial Infarction in Congenital Clotting Factor Abnormalities and Chronic Thrombocytopenias

1983 • 189 citations

Hereditary Protein C Deficiency

1985 • 189 citations

Abnormal Antithrombin III (Antithrombin III ‘Budapest’) as a Cause of a Familial Thrombophilia

1974 • 182 citations

Disseminated Intravascular Coagulation and Related Syndromes: A Clinical Review

1988 • 181 citations

Thromboembolism and Bleeding Tendency in Congenital Factor XII DeficienCy - A Study on 74 Subjects from 14 Swiss Families

1991 • 178 citations

Immunological Studies on Human Antithrombin III

1970 • 176 citations

Disseminated Intravascular Coagulation

1980 • 170 citations

Protein-C: biochemistry, physiology, and clinical implications

1983 • 169 citations

Characterization of human, bovine, and horse antithrombin III

1976 • 168 citations

Protein S and the Regulation of Activated Protein C

1984 • 167 citations

Tissue activators of plasminogen.

1966 • 167 citations

Detection of a new heparin-dependent inhibitor of thrombin in human plasma.

1981 • 156 citations

Coagulation Studies in 45 Cases of Nephrotic Syndrome without Uremia

1970 • 147 citations

Purification of Two Progressive Antithrombins of Human Plasma

1967 • 145 citations

Homocysteine in the Plasma of Renal Transplant Recipients: Effects of Cofactors for Methionine Metabolism

1981 • 144 citations

Oral contraceptives and blood coagulation: A critical review

1982 • 141 citations

The Demise of John Hageman

1968 • 141 citations

Protein S Deficiency Occurs in the Nephrotic Syndrome

1987 • 140 citations

Determination of functional levels of protein C, an antithrombotic protein, using thrombin-thrombomodulin complex

1984 • 137 citations

Clinical Relevance of Antithrombin III

1982 • 134 citations

Activation of Purified Prothrombin to Autoprothrombin I or Autoprothrombin II (Platelet Cofactor II or Autoprothrombin II-A)

1961 • 131 citations

A catalytic role for heparin

1978 • 128 citations

Binding of Thrombin to Antithrombin III

1969 • 127 citations

Incidence and clinical characteristics of hereditary disorders associated with venous thrombosis

1991 • 127 citations

The spectrum of genetic defects in a panel of 40 Dutch families with symptomatic protein C deficiency type I: heterogeneity and founder effects

1991 • 126 citations

Clinical experience with antithrombin III concentrate in treatment of congenital and acquired deficiency of antithrombin

1989 • 125 citations

Alteration in Fibrinolysis Associated With Surgery and Venous Thrombosis

1972 • 117 citations

Nephrotic Syndrome

1971 • 117 citations

A functional assay of protein C in human plasma

1984 • 117 citations

Coagulation Abnormalities in Liver Disease

2008 • 115 citations

Comparison of Progressive Antithrombin Activity and the Concentrations of Three Thrombin Inhibitors in Human Plasma

1970 • 114 citations

Lipoprotein(a) inhibition of plasminogen activation by tissue-type plasminogen activator

1990 • 112 citations

Structure and Function of Protein C

1984 • 112 citations

Vessel proteoglycans and thrombogenesis.

1980 • 110 citations

Assignment of the human antithrombin III structural gene to chromosome 1q23–25

1985 • 109 citations

EFFECT OF COMBINED ŒSTROGEN-PROGESTOGEN ORAL CONTRACEPTIVES, ŒSTROGEN, AND PROGESTOGEN ON ANTIPLASMIN AND ANTITHROMBIN ACTIVITY

1970 • 107 citations

The Relative Frequency of Hereditary Thrombotic Disorders Among 107 Patients with Thrombophilia in Israel

1989 • 106 citations

CONSTITUTIONAL HEPARIN CO-FACTOR II DEFICIENCY ASSOCIATED WITH RECURRENT THROMBOSIS

1985 • 106 citations

Changes in Blood Coagulation and Fibrinolysis in the Nephrotic Syndrome

1974 • 105 citations

Hereditary Heparin Cofactor II Deficiency and the Risk of Development of Thrombosis

1987 • 102 citations

Antithrombin-III deficiency in a Dutch family

1973 • 102 citations

Disturbed fibrinolysis in patients with inflammatory bowel disease. A study in blood plasma, colon mucosa, and faeces.

1989 • 102 citations

Hematology : clinical and laboratory practice

1993 • 100 citations

Elevated total plasma homocysteine, a risk factor for thrombosis. Relation to coagulation and fibrinolytic parameters

1993 • 99 citations

Inherited Resistance to Activated Protein C, a Major Cause of Venous Thrombosis, is due to a Mutation in the Factor V Gene

1994 • 97 citations

Identification of two distinct heparin cofactors in human plasma

1974 • 97 citations

Human hepatoma cells secrete single chain factor X, prothrombin, and antithrombin III

1984 • 97 citations

ASSOCIATION OF HEREDITARY HEPARIN CO-FACTOR II DEFICIENCY WITH THROMBOSIS

1985 • 96 citations

SUCCESSFUL TREATMENT OF HOMOZYGOUS PROTEIN C DEFICIENCY BY HEPATIC TRANSPLANTATION

1988 • 95 citations

Inhibition of thrombin by antithrombin III in the presence of certain glycosaminoglycans found in the mammalian aorta

1978 • 92 citations

The cofactor role of protein S in the acceleration of whole blood clot lysis by activated protein C in vitro

1986 • 91 citations

Evaluation of the safety, recovery, half-life, and clinical efficacy of antithrombin III (human) in patients with hereditary antithrombin III deficiency. Cooperative Study Group [see comments]

1990 • 90 citations

A functional assay for protein C in human plasma

1983 • 90 citations

Antithrombin III (AT-III) as a diagnostic aid in disseminated intravascular coagulation

1977 • 88 citations

Protein C Activation

1984 • 85 citations

Interaction of thrombin and heparin. Proflavine dye binding studies

1974 • 85 citations

Factor XII activity and antigen concentrations in patients suffering from recurrent thrombosis

1987 • 84 citations

Dysfibrinogenemia (Fibrinogen Dusard) Associated with Impaired Fibrin-Enhanced Plasminogen Activation

1984 • 82 citations

Heterogeneity of the "Classical" Antithrombin III Deficiency

1980 • 76 citations

Laboratory Screening of Inherited Thrombotic Syndromes

1987 • 74 citations

Activation and complexation of protein C and cleavage and decrease of protein S in plasma of patients with intravascular coagulation

1989 • 74 citations

Therapeutic Use of Antithrombin III in Shock and Disseminated Intravascular Coagulation

1989 • 72 citations

Fibrinogen Abnormalities

1983 • 71 citations

Sublocalization of the human protein C gene on chromosome 2q13?q14

1989 • 70 citations

Procoagulant and Plasminogen Activator Activities of Bronchoalveolar Fluid in Patients with Pulmonary Sarcoidosis

1988 • 70 citations

Clinical Studies of Protein C

1984 • 68 citations

Fibrinolysis and Atherosclerosis

1988 • 67 citations

Fundamental Interactions and Effect of Storage, Ether, Adsorbants and Blood Clotting on Plasma Antithrombin Activity

1952 • 66 citations

Structural and Functional Characterization of Factor XII

1987 • 65 citations

Deep Vein Thrombosis: Prevalence of Etiologic Factors and Results of Management in 100 Consecutive Patients

1992 • 65 citations

Antithrombin III in fresh and cultured human endothelial cells: A natural anticoagulant from the vascular endothelium

1979 • 65 citations

Identification of two distinct heparin cofactors in human plasma: II. Inhibition of thrombin and activated factor X

1974 • 64 citations

Disseminated Intravascular Coagulation

1992 • 64 citations

A new two-stage functional assay for antithrombin-III (Heparin cofactor): Clinical and laboratory evaluation

1976 • 63 citations

Antithrombin III deficiency: an etiology of Budd-Chiari syndrome.

1985 • 61 citations

Antithrombin III Patterns in Disseminated Intravascular Coagulation

1980 • 61 citations

Hypercoagulability and Thrombosis

1992 • 61 citations

Antithrombin III: Critical Review of Assay Methods. Significance of Variations in Health and Disease

1977 • 61 citations

Laboratory Evaluation of Protein S Status

1990 • 59 citations

THROMBOPHILIA:ITS CAUSES AND A ROUGH ESTIMATE OF ITS PREVALENCE

1987 • 59 citations

Disorders of Thrombosis and Hemostasis: Clinical and Laboratory Practice

1992 • 55 citations

Elevated Plasminogen Activator Inhibitor (PAI), a Cause of Thrombophilia? – A Study in 203 Patients with Familial or Sporadic Venous Thrombophilia

1989 • 54 citations

Abnormal plasminogen, a case of recurrent thrombosis

1981 • 54 citations

Antithrombin III deficiency

1988 • 54 citations

Acquired Antithrombin III Deficiency in Patients with Glomerular Proteinuria

1978 • 53 citations

Assay of dermatan sulfate cofactor (heparin cofactor II) activity in human plasma

1984 • 53 citations

NEUTRALIZATION OF AUTOPROTHROMBIN C ACTIVITY WITH ANTITHROMBIN

1964 • 53 citations

Protein S is a cofactor for activated protein C neutralization of an inhibitor of plasminogen activation released from platelets

1987 • 51 citations

ANTITHROMBIN III AND THE ŒSTROGEN CONTENT OF COMBINED ŒSTRO-PROGESTAGEN CONTRACEPTIVES

1972 • 51 citations

Impaired Fibrinolytic Capacity and Tissue Plasminogen Activator Release in Patients with Restenosis after Percutaneous Transluminal Coronary Angioplasty (PTCA)

1989 • 50 citations

ANTITHROMBIN IN INFANCY AND CHILDHOOD

1975 • 50 citations

Antithrombin III concentrate as adjuvant in DIC treatment a pilot study in 9 severely ill patients

1984 • 48 citations

Changes in Antithrombin III and Plasminogen Induced by Oral Contraceptives

1970 • 47 citations

Three Abnormal Fibrinogen Variants with the Same Amino Acid Substitution (γ 275 Arg → His): Fibrinogens Bergamo II, Essen and Perugia

1986 • 47 citations

Laboratory Diagnosis of Antithrombin and Heparin Cofactor II Deficiency

1990 • 47 citations

At III content and antithrombin activity in oestrogen-progestogen and progestogen-only treated women

1980 • 46 citations

Oral contraceptives reduce total protein S, but not free protein S.

1987 • 45 citations

Pathophysiology of Generalized Intravascular Coagulation

2008 • 45 citations

Laboratory Diagnosis of Protein C Deficiency

1990 • 45 citations

Hereditary Protein S Deficiency

1985 • 45 citations

Laboratory Evaluation of Antithrombin III: A Critical Overview of Currently Available Methods for Antithrombin III Measurements

1982 • 44 citations

Inactivation and binding of human plasma kallikrein by antithrombin III and heparin

1976 • 42 citations

Antithrombin III Alger: A New Homozygous AT III Variant

1986 • 42 citations

Cerebral Thromboembolism Due to Antithrombin III Deficiency in Two Children

1987 • 41 citations

Plasma concentrations of C4b‐binding protein and vitamin K‐dependent protein S in term and preterm infants: low levels of protein S‐C4b‐binding protein complexes

1988 • 40 citations

Fibrinogen Nijmegen : Congenital Dysfibrinogenemia Associated with Impaired t-PA Mediated Plasminogen Activation and Decreased Binding of t-PA

1988 • 38 citations

Familial hypofibrinolysis and venous thrombosis

1989 • 36 citations

The Determination of Antithrombin III

1978 • 36 citations

Clinical aspects of antithrombin III deficiency.

1991 • 36 citations

New perspectives in coagulation testing.

1980 • 36 citations

Inhibition of thrombin-induced platelet aggregation and serotonin release by antithrombin III and heparin cofactor II in the presence of standard heparin, dermatan sulfate and pentosan polysulfate

1984 • 34 citations

Disseminated intravascular coagulation syndromes.

1992 • 34 citations

Identification of heparin cofactor II as the principal plasma cofactor for the antithrombin activity of pentosan polysulphate (SP54)

1984 • 33 citations

Incidence of increased plasminogen activator inhibitor in patients with deep venous thrombosis and/or pulmonary embolism

1989 • 33 citations

Fibrinolytic Activity in Acute Myocardial Infarction

1972 • 33 citations

Acute promyelocytic leukemiaA model for understanding the role of the malignant cell in hemostasis

1974 • 31 citations

Total and free protein S in nephrotic syndrome

1988 • 30 citations

Inactivation of heparin cofactor II by polymorphonuclear leukocytes

1987 • 29 citations

UROKINASE INHIBITORS IN SERUM IN A CLINICAL SERIES

1971 • 29 citations

Heparin Cofactor II and Other Endogenous Factors in the Mediation of the Antithrombotic and Anticoagulant Effects of Heparin and Dermatan Sulfate

1985 • 29 citations

The effects of oestrogen administration on the plasma free protein S and C4b-binding protein

1988 • 28 citations

Association between Alveolar Macrophage Plasminogen Activator Activity and Indices of Lung function in Young Cigarette Smokers

1988 • 27 citations

Recurrent deletion in the human antithrombin III gene

1991 • 27 citations

Low heparin cofactor ii associated with abnormal crossed immunoelectrophoresis pattern in two norwegian families

1987 • 26 citations

INACTIVATION OF PURIFIED AUTOPROTHROMBIN I WITH ANTITHROMBIN

1964 • 26 citations

Disseminated Intravascular Coagulation and Related Syndromes.

1983 • 26 citations

Immunochemical Analysis of Active and Inactive Antithrombin III

1980 • 25 citations

Heparin Interaction with Activated Factor X and Its Inhibitor

1975 • 24 citations

Long‐Term Treatment with Combined Oral Contraceptives and Cigarette Smoking Associated with Impaired Activity of Tissue Plasminogen Activator

1986 • 24 citations

Disseminated Intravascular Coagulation

1992 • 24 citations

Hereditary dysfibrinogenemia.

1985 • 23 citations

Platelet antithrombin deficiency

1978 • 23 citations

Studies of the Effects of Estradiol, Progesterone, Cortisol, Thrombophlebitis, and Typhoid Vaccine on Synthesis and Catabolism of Antithrombin III in the Dog

1977 • 23 citations

Antithrombin III: Comparison of Functional and Immunologic Assays

1978 • 23 citations

Natural Inhibitors of the Coagulation System

1982 • 21 citations

Low protein s in essential thrombocythemia with thrombosis

1989 • 21 citations

Thrombotic Thrombocytopenic Purpura: An Extended Editorial

2008 • 20 citations

The levels of protein C and protein S in plasma in patients with type II diabetes mellitus

1988 • 20 citations

Production of plasminogen activator by alveolar macrophages in normal subjects and patients with interstitial lung disease.

1988 • 20 citations

Clinical Hemostasis Practice: The Major Impact of Laboratory Automation

1983 • 18 citations

A survey of inherited thrombotic syndromes in italy

1989 • 18 citations

Hereditary thrombophilia among 217 consecutive patients with thromboembolic disease in Jordan

1993 • 18 citations

Theoretic and Practical Considerations on Laboratory Monitoring of Thrombolytic Therapy

1987 • 17 citations

Behavior of protein S during long-term oral anticoagulant therapy

1988 • 17 citations

Plasma and Urinary Heparin Cofactor II Levels in Patients with Nephrotic Syndrome

1988 • 17 citations

Acquired and congenital clotting syndromes

1990 • 16 citations

Clinical and Laboratory Features of Homocystinuria

1989 • 16 citations

Heparin cofactor II in adults and infants with thrombosis and DIC

1989 • 16 citations

A Clinical Comparison Of Chromogenic, Fluorometric, And Natural (Fibrinogen) Substrate Assays For Determination Of Antithrombin-III

1981 • 15 citations

The role of specific forms of heparan sulfate in regulating blood vessel wall function.

1986 • 14 citations

The molecular mechanisms of heparin action: II. Separation of functionally different heparins by affinity chromatography

1979 • 14 citations

ANTITHROMBIN III AND ŒSTROGEN CONTENT OF ORAL CONTRACEPTIVES

1973 • 13 citations

Antithrombin III replacement therapy in pregnancy.

1991 • 12 citations

Heparin cofactor II in patients with deep venous thrombosis under heparin and oral anticoagulant therapy

1988 • 12 citations

Fibrinolytic activity. Changes induced with oral contraceptives.

1972 • 12 citations

Radiolabelled ATIII as a probe for the detection of activation of blood coagulation

1976 • 12 citations

Antithrombin III in adolescents

1979 • 11 citations

Inhibition of Thrombin-Neutralizing Activity of Antithrombin III by Steroid Hormones

1982 • 11 citations

Dysfibrinogenemia and lupus anticoagulant in a patient with recurrent thrombosis.

1987 • 11 citations

Plasma protein S deficiency and thromboembolic disease.

1987 • 10 citations

The Fibrinolytic System in Patients with Diabetes mellitus with Special Reference to Diabetic Retinopathy

1975 • 10 citations

Plasminogen Abnormalities

1983 • 9 citations

Methodological considerations on antithrombin determination.

1982 • 9 citations

Hypercoagulability and Thrombosis

1992 • 8 citations

Inhibitor Abnormalities

1983 • 7 citations

Absent elevations in growth hormone, factor VIII related antigen, and plasminogen activator activity during exercise in diabetic patients resistant to retinopathy.

1988 • 7 citations

Heparin cofactor II: a simple assay method and results of its clinical application

1987 • 7 citations

Congenital Antithrombin III Deficiency in 3 Families (7 Affected Members)

1979 • 5 citations

[Homocystinuria accompanied with cerebral deep venous thrombosis--a case report].

1990 • 4 citations