Pax: Genes for mice and men

Mutations affecting segment number and polarity in Drosophila

1980 • 4,280 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

PROTEIN-DNA RECOGNITION

1984 • 1,649 citations

Pax-6, a murine paired box gene, is expressed in the developing CNS

1991 • 1,226 citations

Mouse Small eye results from mutations in a paired-like homeobox-containing gene

1991 • 1,124 citations

Pax-3, a novel murine DNA binding protein expressed during early neurogenesis.

1991 • 897 citations

Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5

1991 • 856 citations

Positional cloning and characterization of a paired box- and homeobox-containing gene from the aniridia region

1991 • 850 citations

The proline-rich transcriptional activator of CTF/NF-I is distinct from the replication and DNA binding domain

1989 • 781 citations

Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression

1991 • 698 citations

Control of cell pattern in the developing nervous system: Polarizing activity of the floor plate and notochord

1991 • 698 citations

Differential transcriptional activation by Oct-1 and Oct-2: Interdependent activation domains induce Oct-2 phosphorylation

1990 • 696 citations

Waardenburg's syndrome patients have mutations in the human homologue of the Pax-3 paired box gene

1992 • 692 citations

Sequence of a Drosophila segmentation gene: protein structure homology with DNA-binding proteins

1984 • 686 citations

splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3

1991 • 664 citations

Genomic structure, evolutionary conservation and aniridia mutations in the human PAX6 gene

1992 • 643 citations

A new syndrome combining developmental anomalies of the eyelids, eyebrows and nose root with pigmentary defects of the iris and head hair and with congenital deafness.

1951 • 627 citations

Murine Developmental Control Genes

1990 • 594 citations

The midbrain-hindbrain phenotype of Wnt-1−Wnt-1− mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum

1992 • 579 citations

The human PAX6 gene is mutated in two patients with aniridia

1992 • 565 citations

Pax2, a new murine paired-box-containing gene and its expression in the developing excretory system

1990 • 562 citations

Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcoma

1993 • 546 citations

Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox geneHox-#150;1.6

1992 • 537 citations

Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis.

1992 • 536 citations

A single amino acid can determine the DNA binding specificity of homeodomain proteins

1989 • 531 citations

The Development of the Rat Spinal Cord

1984 • 513 citations

Conservation of a large protein domain in the segmentation gene paired and in functionally related genes of Drosophila

1986 • 497 citations

Structure of the segmentation gene paired and the Drosophila PRD gene set as part of a gene network

1986 • 496 citations

Pax-3 is required for the development of limb muscles: a possible role for the migration of dermomyotomal muscle progenitor cells

1994 • 495 citations

Divergent homeo box proteins recognize similar DNA sequences in Drosophila

1988 • 491 citations

Pax8, a murine paired box gene expressed in the developing excretory system and thyroid gland

1990 • 479 citations

An exonic mutation in the HuP2 paired domain gene causes Waardenburg's syndrome

1992 • 470 citations

POU-domain transcription factors: pou-er-ful developmental regulators.

1991 • 461 citations

Expression of the zebrafish paired box gene pax[zf-b] during early neurogenesis

1991 • 443 citations

Mendelian inheritance in man

1993 • 430 citations

Pax: A murine multigene family of paired box-containing genes

1991 • 427 citations

Pax-2 is a DNA-binding protein expressed in embryonic kidney and Wilms tumor.

1992 • 417 citations

Aniridia. A review

1984 • 406 citations

Spatially and temporally restricted expression of Pax2 during murine neurogenesis

1990 • 397 citations

The murine paired box gene, Pax7, is expressed specifically during the development of the nervous and muscular system

1990 • 383 citations

Homeosis in the mouse induced by a null mutation in the Hox-3.1 gene

1992 • 364 citations

Signals from the notochord and floor plate regulate the region-specific expression of two Pax genes in the developing spinal cord

1993 • 356 citations

The paired box encodes a second DNA-binding domain in the paired homeo domain protein.

1991 • 349 citations

Small eyes (Sey) : a homozygous lethal mutation on chromosome 2 which affects the differentiation of both lens and nasal placodes in the mouse

1986 • 344 citations

Signals from the notochord and floor plate regulate the region-specific expression of two Pax genes in the developing spinal cord

1993 • 326 citations

The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP.

1992 • 325 citations

undulated, a mutation affecting the development of the mouse skeleton, has a point mutation in the paired box of Pax 1

1988 • 323 citations

Pax 1, a member of a paired box homologous murine gene family, is expressed in segmented structures during development

1988 • 304 citations

Pax-8, a paired domain-containing protein, binds to a sequence overlapping the recognition site of a homeodomain and activates transcription from two thyroid-specific promoters.

1992 • 298 citations

Analysis of the developmental effects of a lethal mutation in the house mouse

1954 • 290 citations

Deregulation of Pax-2 expression in transgenic mice generates severe kidney abnormalities

1993 • 284 citations

The molecular basis of the undulated/Pax-1 mutation

1991 • 273 citations

Complete physical map of the WAGR region of 11p13 localizes a candidate Wilms' tumor gene

1990 • 264 citations

Mutations in the paired domain of the human PAX3 gene cause Klein-Waardenburg syndrome (WS-III) as well as Waardenburg syndrome type I (WS-I).

1993 • 250 citations

The oncogenic potential of Pax genes.

1993 • 247 citations

Effect of the notochord on the differentiation of a floor plate area in the neural tube of the chick embryo

1988 • 246 citations

A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation.

1990 • 244 citations

Orientation of commissural axons in vitro in response to a floor plate-derived chemoattractant

1990 • 227 citations

Mutations in the PAX3 gene causing Waardenburg syndrome type 1 and type 2

1993 • 223 citations

Zebrafish pax[zf-a]: a paired box-containing gene expressed in the neural tube.

1991 • 213 citations

Structure of two genes at the gooseberry locus related to the paired gene and their spatial expression during Drosophila embryogenesis.

1987 • 213 citations

Chromosomal localization of seven PAX genes and cloning of a novel family member, PAX-9

1993 • 212 citations

Conservation of the paired domain in metazoans and its structure in three isolated human genes.

1989 • 210 citations

The Splotch mutation interferes with muscle development in the limbs

1993 • 205 citations

Production of a mutation in mouse En-2 gene by homologous recombination in embryonic stem cells

1989 • 200 citations

Persistent truncus arteriosus in the Splotch mutant mouse

1989 • 184 citations

Small eye (Sey): a mouse model for the genetic analysis of craniofacial abnormalities

1988 • 182 citations

A mutation within intron 3 of the Pax-3 gene produces aberrantly spliced mRNA transcripts in the splotch (Sp) mouse mutant.

1993 • 180 citations

Comparative analysis of Pax-2 protein distributions during neurulation in mice and zebrafish

1992 • 169 citations

Isolation of two tissue-specific Drosophila paired box genes, Pox meso and Pox neuro.

1989 • 161 citations

Alternative splicing of Pax-8 gene transcripts is developmentally regulated and generates isoforms with different transactivation properties.

1993 • 150 citations

A Mouse Model of the Aniridia-Wilms Tumor Deletion Syndrome

1990 • 136 citations

Zebrafish pax[b] is involved in the formation of the midbrain–hindbrain boundary

1992 • 127 citations

Analysis of the Pax-3 Gene in the Mouse Mutant Splotch

1993 • 125 citations

The Antennapedia-type homeobox genes have evolved from three precursors separated early in metazoan evolution.

1993 • 121 citations

Pax-5 is expressed at the midbrain-hindbrain boundary during mouse development

1992 • 113 citations

The Splotch-Delayed (Spd) Mouse Mutant Carries a Point Mutation within the Paired Box of the Pax-3 Gene

1993 • 112 citations

Development of floor plate, neurons and axonal outgrowth pattern in the early spinal cord of the notochord-deficient chick embryo

1991 • 112 citations

Assignment of the locus for Waardenburg syndrome type I to human chromosome 2q37 and possible homology to the Splotch mouse.

1990 • 112 citations

Do multigene families regulate vertebrate development?

1988 • 109 citations

The effects of notochordectomy in Amblystoma mexicanum

1949 • 101 citations

A frameshift mutation in the HuP2 paired domain of the probable human homolog of murine Pax-3 is responsible for Waardenburg syndrome type 1 in an Indonesian family

1992 • 93 citations

The gooseberry-zipper region of Drosophila : five genes encode different spatially restricted transcripts in the embryo

1987 • 87 citations

Effect of a notochordal implant on the early morphogenesis of the neural tube and neuroblasts: Histometrical and histological results

1985 • 80 citations

Delayed neural crest cell emigration from Sp and Sp^d mouse neural tube explants

1990 • 79 citations

Development of Dickie's small eye, a mutation in the house mouse

1979 • 78 citations

Waardenburg syndrome type I in a child with de novo inversion (2)(q35q37.3)

1989 • 77 citations

The Effect of the Floor Plate on Pattern and Polarity in the Developing Central Nervous System

1991 • 77 citations

Induction of an additional floor plate in the neural tube.

1985 • 74 citations

Small eyes—a new dominant eye mutant in the mouse

1967 • 73 citations

Splotch locus mouse mutants: models for neural tube defects and Waardenburg syndrome type I in humans.

1992 • 69 citations

Induction of somite chondrogenesis by cartilage and notochord: A correlation between inductive activity and specific stages of cytodifferentiation

1965 • 68 citations

The paired domain‐containing nuclear factor Pax[b] is expressed in specific commissural interneurons in zebrafish embryos

1992 • 65 citations

Defective Ensheathment of Motoric Nerves in the Splotch Mutant Mouse

1990 • 65 citations

Murine Pax-2 Protein Is a Sequence-SpecificTrans-Activator with Expression in the Genital System

1993 • 58 citations

Genetical studies on the skeleton of the mouse. I. Minor variations of the vertebral column.

1950 • 57 citations

NEW SPLOTCH ALLELES IN THE MOUSE

1964 • 56 citations

Genetical studies on the skeleton of the mouse

1950 • 54 citations

Cloning of Breakpoints of a Chromosome Translocation Identifies the AN2 Locus

1989 • 53 citations

A new Pax gene, Pax-9, maps to mouse Chromosome 12

1993 • 51 citations

Molecular characterization of a deletion encompassing the splotch mutation on mouse chromosome 1

1991 • 51 citations

Waardenburg syndrome and myelomeningocele in a family.

1993 • 50 citations

Spinal ganglia reduction in the splotch‐delayed mouse neural tube defect mutant

1989 • 49 citations

Functional dissection of the paired segmentation gene in Drosophila embryos.

1991 • 49 citations

Location of the gene involving the Small eye mutation on mouse chromosome 2 suggests homology with human aniridia 2 (AN2)

1990 • 47 citations

A probable case of the homozygous condition of the aniridia gene.

1980 • 47 citations

Waardenburg I syndrome: A clinical and genetic study of two large Brazilian kindreds, and literature review

1991 • 46 citations

Undulated: A new genetic factor in mus musculus affecting the spine and tail

1947 • 46 citations

Genetical studies on the skeleton of the mouse xvi. Tail-kinks

1955 • 40 citations

Early morphological abnormalities in splotch mouse embryos and predisposition to gene‐ and retinoic acid‐induced neural tube defects

1983 • 38 citations

The Waardenburg syndrome.

1971 • 33 citations

Is the presumptive notochord responsible for somite genesis in the chick?

1970 • 30 citations

Development of the Skeletal System

2007 • 28 citations

Abnormalities of neural tube formation in pre‐spina bifida splotch‐delayed mouse embryos

1991 • 26 citations

Ataxia with aniridia of Gillespie

1981 • 24 citations

Long-range restriction map around 11p13 aniridia locus

1989 • 22 citations

An inherited agent of mutation with chromosome damage in wild mice

1985 • 21 citations

Basal lamina and extracellular matrix alterations in the caudal neural tube of the delayed Splotch embryo

1987 • 17 citations

The young notochord can induce somite genesis by means of diffusible substances in the chick

1971 • 17 citations

The syndrome of Waardenburg.

1959 • 16 citations