Production of a mutation in mouse En-2 gene by homologous recombination in embryonic stem cells

Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia

1985 • 9,128 citations

Establishment in culture of pluripotential cells from mouse embryos

1981 • 8,424 citations

Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells.

1981 • 5,629 citations

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

1987 • 2,368 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

Targetted correction of a mutant HPRT gene in mouse embryonic stem cells

1987 • 786 citations

Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector

1986 • 761 citations

Transgenesis by means of blastocyst-derived embryonic stem cell lines.

1986 • 432 citations

Buffalo rat liver cells produce a diffusible activity which inhibits the differentiation of murine embryonal carcinoma and embryonic stem cells

1987 • 403 citations

En-1 and En-2, two mouse genes with sequence homology to the Drosophila engrailed gene: expression during embryogenesis.

1987 • 330 citations

Expression during embryogenesis of a mouse gene with sequence homology to the Drosophila engrailed gene

1985 • 234 citations

Expression of the homeo box-containing gene En-2 delineates a specific region of the developing mouse brain.

1988 • 225 citations

Recombinant fragment assay for gene targetting based on the polymerase chain reaction

1988 • 192 citations

Homologous integration in mammalian cells without target gene selection.

1988 • 172 citations

5' flanking and first intron sequences of the human β-actin gene required for efficient promoter activity

1989 • 73 citations