Controlled conversion of an immortalized mesodermal progenitor cell towards osteogenic, chondrogenic, or adipogenic pathways.

The protein Id: A negative regulator of helix-loop-helix DNA binding proteins

1990 • 2,273 citations

Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

1985 • 2,145 citations

The cadherins: cell-cell adhesion molecules controlling animal morphogenesis

1988 • 1,626 citations

Regulation of development and differentiation by the extracellular matrix

1993 • 1,216 citations

Multiple new phenotypes induced in and 3T3 cells treated with 5-azacytidine

1979 • 1,101 citations

Relationship between cell shape and type of collagen synthesised as chondrocytes lose their cartilage phenotype in culture

1977 • 1,054 citations

Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures

1992 • 829 citations

Osteoporosis and the Replacement of Cell Populations of the Marrow by Adipose Tissue

1971 • 743 citations

Precursor Cells of Mechanocytes

1976 • 741 citations

Cellular and Molecular Aspects of Adipose Tissue Development

1992 • 671 citations

Differentiation of muscle, fat, cartilage, and bone from progenitor cells present in a bone-derived clonal cell population: effect of dexamethasone.

1988 • 656 citations

Regulation of Adipocyte Development

1994 • 631 citations

Bone Morphogenetic Protein-2 Causes Commitment and Differentiation in C3Hl0T1/2 and 3T3 Cells

1993 • 487 citations

Molecular cloning of mRNA from 3T3 adipocytes. Regulation of mRNA content for glycerophosphate dehydrogenase and other differentiation-dependent proteins during adipocyte development.

1983 • 476 citations

The developmental fate of the cephalic mesoderm in quail-chick chimeras

1992 • 434 citations

Osteogenic Stem Cells and the Stromal System of Bone and Marrow

1989 • 394 citations

Bone and cartilage differentiation

1994 • 389 citations

A community effect in animal development

1988 • 388 citations

A chondrogenic cell line derived from a differentiating culture of AT805 teratocarcinoma cells

1990 • 384 citations

Complete primary structure of the rat cartilage proteoglycan core protein deduced from cDNA clones.

1987 • 367 citations

Adipocytic cells cultured from marrow have osteogenic potential

1991 • 363 citations

Changes in type of collagen synthesized as clones of chick chondrocytes grow and eventually lose division capacity.

1976 • 355 citations

Expression of Human Bone Morphogenetic Proteins-2 or -4 in Murine Mesenchymal Progenitor C3H10T½ Cells Induces Differentiation into Distinct Mesenchymal Cell Lineages

1993 • 340 citations

5-azacytidine induction of stable mesodermal stem cell lineages from 10T1/2 cells: Evidence for regulatory genes controlling determination

1984 • 330 citations

The sequence of cDNA encoding lipoprotein lipase. A member of a lipase gene family.

1987 • 300 citations

Expression of the mouse α1 (II) collagen gene is not restricted to cartilage during development

1991 • 264 citations

The M-twist gene of Mus is expressed in subsets of mesodermal cells and is closely related to the Xenopus X-twi and the Drosophila twist genes

1991 • 259 citations

Collagen gene expression during limb cartilage differentiation.

1986 • 238 citations

Role of transforming growth factor-β in chondrogenic pattern formation in the embryonic limb: Stimulation of mesenchymal condensation and fibronectin gene expression by exogenenous TGF-β and evidence for endogenous TGF-β-like activity

1991 • 229 citations

Stimulation of chondrogenesis in limb bud mesoderm cells by recombinant human bone morphogenetic protein 2B (BMP-2B) and modulation by transforming growth factor ?1 and ?2*1

1991 • 205 citations

Hypertrophic chondrocytes undergo further differentiation in culture

1992 • 192 citations

Characterization of the rat osteocalcin gene: stimulation of promoter activity by 1,25-dihydroxyvitamin D3

1988 • 189 citations

Gene expression during osteogenic differentiation in mandibular condyles in vitro.

1990 • 177 citations

Regulation of Collagen Gene Expression

1989 • 171 citations

Changes in the expression of collagen genes show two stages in chondrocyte differentiation in vitro

1988 • 169 citations

Specific hybridization probes for mouse type I, II, III and IX collagen mRNAs

1991 • 165 citations

Responsiveness of clonal limb bud cell lines to bone morphogenetic protein 2 reveals a sequential relationship between cartilage and bone cell phenotypes

1994 • 157 citations

Induction and prevention of chondrocyte hypertrophy in culture.

1989 • 151 citations

Clonal osteogenic cell lines express myogenic and adipocytic developmental potential

1991 • 137 citations

Preferential Expression of Alternatively Spliced mRNAs Encoding Type II Procollagen with a Cysteine-Rich Amino-Propeptide in Differentiating Cartilage and Nonchondrogenic Tissues during Early Mouse Development

1993 • 128 citations

Retinoic acid rapidly reduces cartilage matrix synthesis by altering gene transcription in chondrocytes

1987 • 120 citations

The transient expression of type II collagen at tissue interfaces during mammalian craniofacial development

1991 • 114 citations

Modulation of chondrogenesis by the cytoskeleton and extracellular matrix

1991 • 113 citations

The developmental specification of the vertebrate skull.

1988 • 97 citations

Cloning of the human and mouse type X collagen genes and mapping of the mouse type X collagen gene to chromosome 10

1992 • 93 citations

Hormonal responsiveness of a preadipose cell line derived from newborn mouse calvaria

1982 • 89 citations

Activin Enhances Chondrogenesis of Limb Bud Cells: Stimulation of Precartilaginous Mesenchymal Condensations and Expression of NCAM

1993 • 86 citations

Comparative investigation of vitamins and their analogues on terminal differentiation, from preadipocytes to adipocytes, of 3T3-L1 cells

1990 • 86 citations

Link protein cDNA sequence reveals a tandemly repeated protein structure.

1986 • 84 citations

Expression of simian virus 40 large T (tumor) oncogene in mouse chondrocytes induces cell proliferation without loss of the differentiated phenotype.

1993 • 84 citations

Expression of the Helix-Loop-Helix Factor Id during Mouse Embryonic Development

1993 • 82 citations

Synthesis of cartilage matrix by mammalian chondrocytes in vitro. III. Effects of ascorbate.

1984 • 81 citations

In vitro morphogenesis of chick embryo hypertrophic cartilage.

1987 • 80 citations

Cloning and regulation of a mRNA specifically expressed in the preadipose state

1989 • 79 citations

Stimulation by glucocorticoid of the synthesis of cartilage-matrix proteoglycans produced by rabbit costal chondrocytes in vitro.

1985 • 76 citations

Ascorbic acid phosphate stimulates type IV collagen synthesis and accelerates adipose conversion of 3T3-L1 cells

1990 • 74 citations

Endosomes and Golgi vesicles in adsorptive and fluid phase endocytosis.

1984 • 74 citations

Effects of Dexamethasone and Vitamin D₃on Cartilage Differentiation in a Clonal Chondrogenic Cell Population

1989 • 73 citations

Primary structure of the mouse glycerol-3-phosphate dehydrogenase gene.

1986 • 72 citations

The Sequence of cDNA Encoding Lipoprotein Lipase

1987 • 72 citations

A skeletal muscle cell line isolated from a mouse teratocarcinoma undergoes apparently normal terminal differentiation in vitro*1

1978 • 71 citations

Gene regulation during cartilage differentiation: temporal and spatial expression of link protein and cartilage matrix protein in the developing limb

1989 • 67 citations

Regulation of expression of the chondrocytic phenotype in a skeletal cell line (CFK2) in vitro

1993 • 65 citations

Ascorbate independent differentiation of human chondrocytes in vitro: simultaneous expression of types I and × collagen and matrix mineralization

1992 • 64 citations

5-Azacytidine is able to induce the conversion of teratocarcinoma-derived mesenchymal cells into epithelia cells.

1984 • 57 citations

Bone-marrow-derived chondrogenesis in vitro

1992 • 54 citations

An immortalized osteogenic cell line derived from mouse teratocarcinoma is able to mineralize in vivo and in vitro.

1990 • 51 citations

Serotonin uptake, storage, and synthesis in an immortalized committed cell line derived from mouse teratocarcinoma.

1990 • 49 citations

Stimulation by Glucocorticoids of the Differentiated Phenotype of Chondrocytes and the Proliferation of Rabbit Costal Chondrocytes in Culture1

1985 • 48 citations

Autocrine or paracrine transforming growth factor-beta modulates the phenotype of chick embryo sternal chondrocytes in serum-free agarose culture.

1993 • 47 citations

The chicken alpha 1 (XI) collagen gene is widely expressed in embryonic tissues.

1992 • 46 citations

Embryology anatomy and microstructure of bone

1992 • 44 citations

Differentiation of cartilage and bone

1989 • 39 citations

Stable murine chondrogenic cell lines derived from c-fos-induced cartilage tumors

1993 • 38 citations

Immortalization of early embryonic cell derivatives after the transfer of the early region of simian virus 40 into F9 teratocarcinoma cells

1986 • 37 citations

Collagen: A Family of Proteins with many Facets

1993 • 36 citations

Establishment of a preadipocyte cell line from the epididymal fat pad of the lean C57 BL/6J mouse—Long term effects of insulin and triiodothyronine on adipose conversion

1983 • 31 citations

Alternative splicing generates two different mRNA species for rat link protein.

1988 • 28 citations

Glucocorticoid control of developmentally regulated adipose genes

1986 • 27 citations

Immortalization of precursors of endodermal, neuroectodermal and mesodermal lineages, following the introduction of the simian virus (SV40) early region into F9 cells

1987 • 25 citations

Kinetics of in vitro mineralization by an osteogenic clonal cell line (C1) derived from mouse teratocarcinoma

1993 • 22 citations

The developmental specification of the vertebrate skull

1988 • 21 citations

Commitment of the teratocarcinoma-derived mesodermal clone c1 towards terminal osteogenic differentiation

1993 • 20 citations

Monoclonal Antibody to the Aminotelopeptide of Type II Collagen: Loss of the Epitope after Stromelysin Digestion

1994 • 13 citations

The ?2(XI) collagen gene lies within 8 kb of Pb in the proximal portion of the murine major histocompatibility complex

1993 • 6 citations