SOX9 Enhances Aggrecan Gene Promoter/Enhancer Activity and Is Up-regulated by Retinoic Acid in a Cartilage-derived Cell Line, TC6

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.

1987 • 4,937 citations

Sox9 is required for cartilage formation

1999 • 1,680 citations

Refinement of the Coomassie blue method of protein quantitation

1978 • 1,573 citations

Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene

1994 • 1,573 citations

Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9

1994 • 1,521 citations

SOX9 Is a Potent Activator of the Chondrocyte-Specific Enhancer of the Proα1(II) Collagen Gene

1997 • 1,051 citations

SOX9 directly regulates the type-ll collagen gene

1997 • 891 citations

A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene

1998 • 792 citations

Sox9 expression during gonadal development implies a conserved role for the gene in testis differentiation in mammals and birds

1996 • 788 citations

Function of the retinoic acid receptors (RARs) during development: (I) Craniofacial and skeletal abnormalities in RAR double mutants

1994 • 755 citations

A male-specific role forSOX9in vertebrate sex determination

1996 • 690 citations

The HMG domain of lymphoid enhancer factor 1 bends DNA and facilitates assembly of functional nucleoprotein structures

1992 • 684 citations

SOX9 Binds DNA, Activates Transcription, and Coexpresses with Type II Collagen during Chondrogenesis in the Mouse

1997 • 665 citations

Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins

1990 • 656 citations

The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos

1995 • 648 citations

Function of retinoic acid receptor γ in the mouse

1993 • 595 citations

Parallel expression ofSox9 andCol2a1 in cells undergoing chondrogenesis

1997 • 496 citations

Parathyroid Hormone-Responsive Clonal Cell Lines from Rat Osteosarcoma*

1980 • 483 citations

The chondrocyte, architect of cartilage. Biomechanics, structure, function and molecular biology of cartilage matrix macromolecules

1995 • 439 citations

Definition of a consensus DNA binding site for SRY

1994 • 381 citations

Target cells in bone for parathormone and calcitonin are different: enrichment for each cell type by sequential digestion of mouse calvaria and selective adhesion to polymeric surfaces.

1975 • 357 citations

Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes.

1993 • 340 citations

Chondrocyte-specific Enhancer Elements in the Col11a2 Gene Resemble the Col2a1 Tissue-specific Enhancer

1998 • 273 citations

Mouse cartilage matrix deficiency (cmd) caused by a 7 bp deletion in the aggrecan gene

1994 • 242 citations

The DNA-binding specificity of SOX9 and other SOX proteins

1999 • 226 citations

Seven new members of theSoxgene family expressed during mouse development

1993 • 211 citations

Mechanism of Regulatory Target Selection by the SOX High-Mobility-Group Domain Proteins as Revealed by Comparison of SOX1/2/3 and SOX9

1999 • 176 citations

Identification of a phenotype-specific enhancer in the first intron of the rat collagen II gene.

1987 • 163 citations

Characterization of primary cultures of chondrocytes from type II collagen/β-galactosidase transgenic mice

1994 • 146 citations

Retinoic acid rapidly reduces cartilage matrix synthesis by altering gene transcription in chondrocytes

1987 • 120 citations

cDNA cloning of alkaline phosphatase from rat osteosarcoma (ROS 17/2.8) cells

1987 • 107 citations

Modulation of the rabbit chondrocyte phenotype by retinoic acid terminates type II collagen synthesis without inducing type I collagen: The modulated phenotype differs from that produced by subculture

1986 • 90 citations

Mouse aggrecan, a large cartilage proteoglycan: protein sequence, gene structure and promoter sequence

1995 • 59 citations

Retardation of skeletal development and cervical abnormalities in transgenic mice expressing a dominant-negative retinoic acid receptor in chondrogenic cells

1998 • 38 citations

Establishment of a novel chondrocyte-like cell line derived from transgenic mice harboring the temperature-sensitive simian virus 40 large T-antigen gene

1996 • 25 citations