A review of the in vitro and in vivo neurochemical characterization of the NMDA/PCP/Glycine/Ion channel receptor macrocomplex

Glycine potentiates the NMDA response in cultured mouse brain neurons

1987 • 3,116 citations

Delayed neuronal death in the gerbil hippocampus following ischemia

1982 • 2,856 citations

Thresholds in cerebral ischemia - the ischemic penumbra.

1981 • 2,780 citations

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

1986 • 1,814 citations

Requirement for Glycine in Activation of NMDA-Receptors Expressed in Xenopus Oocytes

1988 • 1,415 citations

The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartate

1983 • 1,400 citations

Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists

1988 • 983 citations

Cooperative Modulation of [³H]MK‐801 Binding to the N‐Methyl‐d‐Aspartate Receptor‐Ion Channel Complex by l‐Glutamate, Glycine, and Polyamines

1988 • 755 citations

Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels.

1988 • 747 citations

A new type of glutamate receptor linked to inositol phospholipid metabolism

1987 • 743 citations

Glutamate stimulates inositol phosphate formation in striatal neurones

1985 • 734 citations

A Glycine Site Associated with N‐Methyl‐<scp>d</scp>‐Aspartic Acid Receptors: Characterization and Identification of a New Class of Antagonists

1989 • 723 citations

Delayed hippocampal damage in humans following cardiorespiratory arrest

1987 • 710 citations

Hypoglycemia-Induced Neuronal Damage Prevented by an N -Methyl-D-Aspartate Antagonist

1985 • 673 citations

Amino acid neurotransmitters and their pathways in the mammalian central nervous system

1983 • 646 citations

Lipoxygenase metabolites of arachidonic acid as second messengers for presynaptic inhibition of Aplysia sensory cells

1987 • 640 citations

NMDA receptors activate the arachidonic acid cascade system in striatal neurons

1988 • 600 citations

Possible Therapeutic Applications of Antagonists of Excitatory Amino acid Neurotransmitters

1985 • 558 citations

7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex.

1988 • 517 citations

Two classes of N-methyl-D-aspartate recognition sites: differential distribution and differential regulation by glycine.

1988 • 495 citations

Role for Excitatory Amino Acids in Methamphetamine-Induced Nigrostriatal Dopaminergic Toxicity

1989 • 495 citations

II. Excitotoxic models for neurodegenerative disorders

1984 • 469 citations

Excitatory amino acid transmission

1987 • 430 citations

Gangliosides prevent glutamate and kainate neurotoxicity in primary neuronal cultures of neonatal rat cerebellum and cortex.

1988 • 384 citations

The effects of 5-minute ischemia in Mongolian gerbils: II. Changes of spontaneous neuronal activity in cerebral cortex and CA1 sector of hippocampus

1983 • 356 citations

CPP, a new potent and selective NMDA antagonist. Depression of central neuron responses, affinity for [3H]d-AP5 binding sites on brain membranes and anticonvulsant activity

1986 • 311 citations

Quinolinic acid and other kynurenines in the central nervous system

1985 • 311 citations

Kynurenic acid antagonises responses to NMDA via an action at the strychnine-insensitive glycine receptor

1988 • 307 citations

d-Cycloserine: A ligand for the coupled glycine receptor has partial agonist characteristics

1989 • 302 citations

Anatomic correlation of NMDA and 3H-TCP-labeled receptors in rat brain

1988 • 284 citations

MK-801 is neuroprotective in gerbils when administered during the post-ischaemic period

1988 • 276 citations

The effects of excitatory amino acids on intracellular calcium in single mouse striatal neurons in vitro

1987 • 268 citations

Ketamine and phencyclidine cause a voltage-dependent block of responses to l-aspartic acid

1985 • 261 citations

Protection against chemically induced seizures by 2-amino-7-phosphonoheptanoic acid

1982 • 258 citations

D-cycloserine, a positive modulator of the N-methyl-D-aspartate receptor, enhances performance of learning tasks in rats

1989 • 253 citations

Sigma and phencyclidine-like compounds as molecular probes in biology

1988 • 251 citations

N-Methyl-D,L-Aspartate Elicits Hypothalamic Gonadotropin-Releasing Hormone Release in Prepubertal Male Rhesus Monkeys (Macaca mulatto)*

1987 • 249 citations

The N-methyl-d-aspartate antagonists CGS 19755 and CPP reduce ischemic brain damage in gerbils

1988 • 246 citations

Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. I. Evidence for efficacy in models of focal cerebral ischemia.

1988 • 237 citations

HIGH AFFINITY UPTAKE OF TRANSMITTERS: STUDIES ON THE UPTAKE OF <scp>l</scp>‐ASPARTATE, GABA, <scp>l</scp>‐GLUTAMATE AND GLYCINE IN CAT SPINAL CORD

1973 • 236 citations

Differential vulnerability of central neurons of the rat to quinolinic acid

1983 • 232 citations

CPP, a selective N-methyl-D-aspartate (NMDA)-type receptor antagonist: characterization in vitro and in vivo.

1987 • 231 citations

N‐methyl‐D‐aspartate‐activated channels of mouse central neurones in magnesium‐free solutions.

1988 • 230 citations

Glycine potentiates strychnine-induced convulsions: role of NMDA receptors

1988 • 227 citations

NMDA receptors and ligands in the vertebrate CNS

1988 • 226 citations

Excitatory amino acid-induced release of 3H-GABA from cultured mouse cerebral cortex interneurons

1987 • 224 citations

CGS 19755, a selective and competitive N-methyl-D-aspartate-type excitatory amino acid receptor antagonist.

1988 • 219 citations

Neuroprotective effects of MK-801 in vivo: selectivity and evidence for delayed degeneration mediated by NMDA receptor activation

1988 • 216 citations

Multiple sites for the regulation of the N-methyl-D-aspartate receptor.

1988 • 208 citations

Binding of [3H]3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid to rat brain membranes: a selective, high-affinity ligand for N-methyl-D-aspartate receptors.

1987 • 203 citations

6,7-Dinitro-quinoxaline-2,3-dion and 6-nitro,7-cyano-quinoxaline-2,3-dion antagonise responses to NMDA in the rat spinal cord via an action at the strychnine-insensitive glycine receptor

1988 • 197 citations

A STUDY OF A 1-ARYL CYCLO HEXYL AMINE FOR ANESTHESIA*

1958 • 194 citations

Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. II. Evidence for N-methyl-D-aspartate receptor antagonist properties.

1988 • 189 citations

Muscle relaxant and anticonvulsant activity of 3-((±)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid, a novel antagonist, in rodents

1987 • 189 citations

Characterization of the inhibition of excitatory amino acid-induced neurotransmitter release in the rat striatum by phencyclidine-like drugs.

1986 • 187 citations

Radioligand binding to central phencyclidine recognition sites is dependent on excitatory amino acid receptor agonists

1986 • 182 citations

Antiepileptic action of excitatory amino acid antagonists in the photosensitive baboon, papio papio

1983 • 179 citations

Anticonvulsant action of a non-competitive antagonist of NMDA receptors (MK-801) in the kindling model of epilepsy

1989 • 179 citations

The current neurologic burden of illness and injury in the United States

1982 • 178 citations

Characterization of the binding of [³H]‐CGS 19755: a novel N‐methyl‐<scp>d</scp>‐aspartate antagonist with nanomolar affinity in rat brain

1988 • 164 citations

Glycine reverses antagonism of N-methyl-D-aspartate (NMDA) by 1-hydroxy-3-aminopyrrolidone-2 (HA-966) but not by D-2-amino-5-phophonovalerate (D-AP5) on rat cortical slices

1988 • 162 citations

Excitatory amino acids inhibit stimulation of phosphatidylinositol metabolism by aminergic agonists in hippocampus

1986 • 162 citations

N-methyl-D-aspartate receptor-mediated increase in intracellular calcium is reduced by ketamine and phencyclidine

1988 • 156 citations

Excitatory amino acid receptors coupled with guanylate cyclase in primary cultures of cerebellar granule cells

1987 • 146 citations

Excitatory amino acid receptors expressed in Xenopus oocytes: agonist pharmacology.

1988 • 146 citations

Modulation of excitatory synaptic transmission by glycine and zinc in cultures of mouse hippocampal neurons

1988 • 146 citations

Quinolinic acid: regional variations in neuronal sensitivity

1983 • 145 citations

Zinc alters excitatory amino acid neurotoxicity on cortical neurons

1988 • 139 citations

In vitro release and electrophysiological effects in situ of homocysteic acid, an endogenous N-methyl-(D)-aspartic acid agonist, in the mammalian striatum

1986 • 135 citations

Systemic administration of MK-801 prevents neuronal degeneration in rat brain

1987 • 134 citations

Identification and Characterization of an N‐Methyl‐D‐Aspartate‐Specific L‐[³H]Glutamate Recognition Site in Synaptic Plasma Membranes

1987 • 131 citations

7‐クロルキヌレン酸はN‐メチル‐D‐アスパラギン酸受容体複合体のグリシン調節部位での選択的きっ抗物質である

1988 • 130 citations

Phencyclidine selectively inhibits N-methyl-D-aspartate-induced hippocampal [3H]norepinephrine release.

1987 • 125 citations

Does the excitatory amino acid receptor antagonist 2-APH exhibit anxiolytic activity?

1986 • 123 citations

Modulation of glutamate receptors by phencyclidine and glycine in the rat cerebellum: cGMP increase in vivo

1989 • 122 citations

1‐Aminocyclopropane Carboxylic Acid: A Potent and Selective Ligand for the Glycine Modulatory Site of the N‐Methyl‐<scp>d</scp>‐Aspartate Receptor Complex

1989 • 120 citations

Lesions of the glutamatergic cortico-striatal projections in the rat ameliorate hypoglycemic brain damage in the striatum

1985 • 112 citations

Kinetic characterization of the phencyclidine-N-methyl-D-aspartate receptor interaction: evidence for a steric blockade of the channel

1988 • 112 citations

Acute effects of N-methyl-DL-aspartate on the release of pituitary gonadotropins and prolactin in the adult female rhesus monkey

1982 • 110 citations

Antagonism of N-methyl-D-aspartate-induced transmitter release in the rat striatum by phencyclidine-like drugs and its relationship to turning behavior.

1985 • 109 citations

2-amino-7-phosphonoheptanoic acid (AP7) produces discriminative stimuli and anticonflict effects similar to diazepam

1986 • 108 citations

L-Homocysteic acid: An endogenous excitotoxic ligand of the NMDA receptor

1987 • 106 citations

Characterization df a [³H]Glycine Recognition Site as a Modulatory Site of the N‐Methyl‐D‐Aspartate Receptor Complex

1989 • 106 citations

Glycine potentiates [3H]TCP binding to rat cortical membranes

1987 • 105 citations

Glutamate receptors and phosphoinositide metabolism: stimulation via quisqualate receptors is inhibited by receptor activation

1988 • 104 citations

Excitatory Amino Acid Receptor Potency and Subclass Specificity of Sulfur-Containing Amino Acids

1987 • 103 citations

Muscle relaxant action of excitatory amino acid antagonists

1985 • 100 citations

In Vivo Modulation of the N‐Methyl‐D‐Aspartate Receptor Complex by D‐Serine: Potentiation of Ongoing Neuronal Activity as Evidenced by Increased Cerebellar Cyclic GMP

1989 • 100 citations

Differences in results from in vivo and in vitro studies on the use-dependency of N-methylaspartate antagonism by MK-801 and other phencyclidine receptor ligands

1988 • 99 citations

Anticonvulsant effects of phencyclidine-like drugs: relation to N-methyl-d-aspartic acid antagonism

1988 • 99 citations

Antagonists of excitatory amino acids and cyclic guanosine monophosphate in cerebellum

1982 • 97 citations

DL-2-Amino-5-Phosphonopentanoic Acid, a Specific N-Methyl-&lt;i&gt;D&lt;/i&gt;-Aspartic Acid Receptor Antagonist, Suppresses Pulsatile LH Release in the Rat

1988 • 96 citations

Hypothalamic site of action for N-methyl-D-aspartate (NMDA) on LH secretion

1988 • 96 citations

Inhibition by phencyclidine of excitatory amino acid-stimulated release of neurotransmitter in the nucleus accumbens

1987 • 91 citations

Milacemide, a glycine prodrug, enhances performance of learning tasks in normal and amnestic rodents

1989 • 90 citations

Glycine modulation of NMDA-evoked release of [3H]acetylcholine and [3H]dopamine from rat striatal slices

1989 • 87 citations

Magnesium Ions Inhibit the Stimulation of Inositol Phospholipid Hydrolysis by Endogenous Excitatory Amino Acids in Primary Cultures of Cerebellar Granule Cells

1987 • 85 citations

Autoradiographic localization of cerebellar excitatory amino acid binding sites in the mouse

1987 • 82 citations

Is the discriminative stimulus produced by phencyclidine due to an interaction with N-methyl-d-aspartate receptors?

1988 • 78 citations

Pharmacological antagonists of excitant amino acid action

1981 • 77 citations

Anticonvulsant properties of phencyclidine-like drugs in mice

1985 • 76 citations

A simple and rapid method for assessing similarities among directly observable behavioral effects of drugs: PCP-like effects of 2-amino-5-phosphonovalerate in rats

1987 • 76 citations

Acute central stimulation of luteinizing hormone by parenterally administeredN-methyl-D, L-aspartic acid in the male rat

1980 • 75 citations

Interaction of L-glutamate and magnesium with phencyclidine recognition sites in rat brain: evidence for multiple affinity states of the phencyclidine/N-methyl-D-aspartate receptor complex.

1987 • 71 citations

Ketamine: Convulsant or anti-convulsant?

1981 • 71 citations

Linkage between phencyclidine (PCP) and N-methyl-d-aspartate (NMDA) receptors in the cerebellum

1988 • 71 citations

Phencyclidine is a negative allosteric modulator of signal transduction at two subclasses of excitatory amino acid receptors.

1987 • 68 citations

Dual action of excitatory amino acids on the metabolism of inositol phosphates in striatal neurons.

1987 • 68 citations

Interaction of [3H]MK-801 with multiple states of the N-methyl-D-aspartate receptor complex of rat brain.

1989 • 68 citations

Cultured cerebellar cells as an in vitro model of excitatory amino acid receptor function

1987 • 66 citations

Werman R:The cooperativity of -aminobutyric action on the membrane of locust muscle fibers.

1973 • 65 citations

l-Homocysteic acid but not l-glutamate is an endogenous receptor preferring agonist in rat neocortical neurons in vitro

1987 • 64 citations

Glycine modulation of the phencyclidine binding site in mammalian brain

1988 • 63 citations

1-Aminocyclobutane-1-carboxylate (ACBC): a specific antagonist of the N-methyl-D-aspartate receptor coupled glycine receptor

1989 • 61 citations

Cortical lesions modulate turnover rates of acetylcholine and γ-aminobutyric acid

1979 • 60 citations

Mathematical analysis of concentration-response relationships. Method for the evaluation of the ED50 and the number of binding sites per receptor molecule using the logit transformation.

1977 • 60 citations

NMDA-induced hippocampal [3H]norepinephrine release is modulated by glycine

1988 • 58 citations

CGS 19755 is a potent and competitive antagonist at NMDA-type receptors

1988 • 57 citations

Differential effects of phencyclidine (PCP) and ketamine on mesocortical and mesostriatal dopamine release

1989 • 55 citations

Conversion of orally administered 2-n.pentylaminoacetamide into glycinamide and glycine in the rat brain

1983 • 54 citations

Separating receptor subtypes from their shadows

1988 • 53 citations

Kynurenate and 2-amino-5-phosphonovalerate interact with multiple binding sites of the glutamate receptor domain

1989 • 52 citations

Cycloleucine competitively antagonizes the strychnine-insensitive glycine receptor

1988 • 52 citations

1-Aminocyclopropane-1-carboxylic acid (ACC) mimics the effects of glycine on the NMDA receptor ion channel

1988 • 50 citations

Homocysteic Acid as a Putative Excitatory Amino Acid Neurotransmitter: I. Postsynaptic Characteristics at N‐Methyl‐D‐Aspartate‐Type Receptors on Striatal Cholinergic Interneurons

1988 • 50 citations

NMDA- and kainate-evoked GABA release from striatal neurones differentiated in primary culture: Differential blocking by phencyclidine

1988 • 50 citations

A conformationally restricted analogue of l-glutamate, the (2S,3R,4S) isomer of l-α(carboxycyclopropyl)glycine, activates the NMDA-type receptor more markedly than NMDA in the isolated rat spinal cord

1989 • 48 citations

Phencyclidine and glycine modulate NMDA-activated high conductance cationic channels by acting at different sites

1988 • 46 citations

Blockade of N-methyl-d-aspartate-sensitive acidic amino acid receptors inhibits ischemia-induced accumulation of purine catabolites in the rat striatum

1986 • 46 citations

In vivo labelling of the NMDA receptor channel complex by [3H]MK-801

1988 • 45 citations

Antagonism of N-methyl-<scp>D</scp>-aspartate (NMDA) evoked increases in cerebellar cGMP and striatal ACh release by phencyclidine (PCP) receptor agonists; evidence for possible allosteric coupling of NMDA and PCP receptors

1987 • 45 citations

A comparison of the effects of N-methyl-d-aspartate and quinolinate on central neurones of the rat

1984 • 43 citations

A comparison of PCP-like compounds for NMDA antagonism in two models

1988 • 43 citations

[3H]MK801 binding to the N-methyl-D-aspartate receptor reveals drug interactions with the zinc and magnesium binding sites.

1988 • 42 citations

The competitive N-methyl-D-aspartate (NMDA) antagonist CGS 19755 attenuates the rate-decreasing effects of NMDA in rhesus monkeys without producing ketamine-like discriminative stimulus effects

1989 • 41 citations

Release of [3H]norepinephrine from rat hippocampal slices by N-methyl-D-aspartate: comparison of the inhibitory effects of Mg2+ and MK-801

1988 • 40 citations

The N-methyl-D-aspartate antagonist, 2-amino-7-phosphonoheptanoate, produces phencyclidine-like behavioral effects in rats

1987 • 40 citations

Glutamate Stimulates Somatostatin Release from Diencephalic Neurons in Primary Culture*

1988 • 40 citations

NMDA-receptors on Purkinje cell dendrites in guinea pig cerebellar slices

1987 • 39 citations

Anticonvulsant activity of milacemide.

1983 • 38 citations

Quinolinic acid evokes [3H]acetylcholine release in striatal slices: Mediation by NMDA-type excitatory amino acid receptors

1983 • 38 citations

Ibotenic acid stimulates d-[3H]aspartate release from cultured cerebellar granule cells

1989 • 37 citations

Behavioral tolerance and sensitization to CGS 19755, a competitive N-methyl-D-aspartate receptor antagonist.

1988 • 36 citations

Phencyclidine reduces postischemic neuronal necrosis in rat hippocampus without changing blood flow

1988 • 36 citations

Differential electrophysiological and behavioral responses to optically active derivatives of phencyclidine

1981 • 35 citations

In vivo release of [³H]‐purines by quinolinic acid and related compounds

1983 • 35 citations

Heterogeneity of γ‐Aminobutyric Acid/Benzodiazepine/β‐Carboline Receptor Complex in Rat Spinal Cord

1988 • 34 citations

2-amino-7-phosphonoheptanoic acid depresses γ-motoneurons and polysynaptic reflexes in the cat spinal cord

1985 • 34 citations

Paradoxical convulsant action of a novel non-competitiveN-methyl-d-aspartate (NMDA) antagonist, tiletamine

1988 • 32 citations

Homocysteic acid: convulsant action of stereoisomers in mice

1989 • 31 citations

Glycine antagonist action of 1-aminocyclobutane-1-carboxylate (ACBC) in Xenopus oocytes injected with rat brain mRNA

1989 • 30 citations

Neuropharmacological characterization of 1-Aminocyclopropane-1-carboxylate and 1-Aminocyclobutane-1-carboxylate, Ligands of the N-Methyl-D-Aspartate-associated Glycine Receptor

1990 • 30 citations

Glycine reverses 7-Cl kynurenate blockade of glutamate neurotoxicity in cell culture

1989 • 29 citations

Stereoselective antagonism of NMDA-stimulated noradrenaline release from rat hippocampal slices by MK-801

1988 • 28 citations

Trans-2-carboxy-3-pyrrolidineacetic acid (CPAA), a novel agonist at NMDA-type receptors

1988 • 27 citations

The glycine-prodrug, milacemide, increases the seizure threshold due to hyperbaric oxygen; prevention by 1-deprenyl

1988 • 26 citations

Excitatory amino acids inhibit stimulated phosphoinositide hydrolysis in the rat prefrontal cortex

1989 • 26 citations

A comparison of the effects of quinolinate and N-methyl-aspartate on neurons in rat piriform cortex

1986 • 24 citations

Continuously infused 2-amino-7-phosphonoheptanoic acid antagonizes N-methyl-d-aspartate-induced elevations of cyclic GMP in vivo in multiple brain areas and chemically-induced seizure activity

1986 • 21 citations

Lesions to the Corticostriatal Pathways Ameliorate Hypoglycemia‐Induced Arachidonic Acid Release

1986 • 18 citations

The interaction of glutamic and aspartic acids with excitatory amino acid receptors in the mammalian central nervous system

1976 • 17 citations

NMDA-coupled and uncoupled forms of the PCP receptor: Preliminary in vivo evidence for PCP receptor subtypes

1989 • 16 citations

Autoradiographic distribution of [3H]dexoxadrol (a phencyclidine-related ligand) binding sites in rat and human brain

1985 • 16 citations

In vivo characterization of phencyclidine/σ agonist-mediated inhibition of nociception

1989 • 16 citations

Cation interactions with putative NMDA receptor-gated channels labeled by [3H]MK-801 in rat cerebral cortex

1988 • 15 citations

Effects of <scp>dl</scp>‐2‐Amino‐5‐Phosphonovalerate on Metabolism of Catecholamines in Synaptosomes from Rat Brain

1989 • 12 citations

The actions of cyclopentane analogues of glutamic acid at binding sites for kainic and glutamic acids

1988 • 8 citations

Kynurenic acid and AP5 distinguish between NMDA receptor agonists

1988 • 7 citations

The action of quinolinate in the rat spinal cord in vitro

1987 • 7 citations

The high pressure neurological syndrome and 2-amino-7-phosphonoheptanoic acid: Differences between fed and fasted rats

1984 • 6 citations

Effect of central administration of phencyclidine on plasma concentrations of luteinizing hormone

1989 • 1 citations