II. Excitotoxic models for neurodegenerative disorders

Excitatory Amino Acid Transmitters

1981 • 2,488 citations

Brain Lesions, Obesity, and Other Disturbances in Mice Treated with Monosodium Glutamate

1969 • 1,802 citations

Lesion of striatal neurons with kainic acid provides a model for Huntington's chorea

1976 • 1,247 citations

Quinolinic Acid: An Endogenous Metabolite That Produces Axon-Sparing Lesions in Rat Brain

1983 • 1,247 citations

The Toxic Effect of Sodium L-Glutamate on the Inner Layers of the Retina

1957 • 1,061 citations

THE EXCITATION AND DEPRESSION OF SPINAL NEURONES BY STRUCTURALLY RELATED AMINO ACIDS

1960 • 853 citations

Duplication of biochemical changes of Huntington's chorea by intrastriatal injections of glutamic and kainic acids

1976 • 832 citations

Cytotoxic effects of acidic and sulphur containing amino acids on the infant mouse central nervous system

1971 • 808 citations

Intraventricular kainic acid preferentially destroys hippocampal pyramidal cells

1978 • 745 citations

Quinolinic acid: A potent endogenous excitant at amino acid receptors in CNS

1981 • 728 citations

Anticonvulsant Action of Excitatory Amino Acid Antagonists

1982 • 692 citations

The role of calcium in cell death

1981 • 637 citations

Ibotenic acid-induced neuronal degeneration: A morphological and neurochemical study

1979 • 467 citations

GLUTAMATE-INDUCED NEURONAL NECROSIS IN THE INFANT MOUSE HYPOTHALAMUS

1971 • 409 citations

Kainate-induced degeneration of neostriatal neurons: dependency upon corticostriatal tract

1978 • 330 citations

Long-term effects of intrahippocampal kainic acid injection in rats: A method for inducing spontaneous recurrent seizures

1982 • 299 citations

MESIAL TEMPORAL (AMMON'S HORN) SCLEROSIS AS A COMMON CAUSE OF EPILEPSY

1974 • 294 citations

Kainic acid stimulates excitatory amino acid neurotransmitter release at presynaptic receptors

1982 • 285 citations

Actions of several anthelmintics and insecticides on rat cortical neurones

1970 • 266 citations

ACTION OF THE NEUROTOXIN KAINIC ACID ON HIGH AFFINITY UPTAKE OF <scp>l</scp>‐GLUTAMIC ACID IN RAT BRAIN SLICES

1979 • 263 citations

Evidence suggesting secondary epileptogenic lesions after kainic acid: pretreatment with diazepam reduces distant but not local brain damage

1979 • 249 citations

Glutamic Acid: Advances in Biochemistry and Physiology

1980 • 240 citations

Comparison of ibotenate and kainate neurotoxicity in rat brain: A histological study

1983 • 236 citations

Differential vulnerability of central neurons of the rat to quinolinic acid

1983 • 232 citations

Autoradiographic localization of high-affinity [3H]kainic acid binding sites in the rat forebrain

1983 • 227 citations

Central actions of ibotenic acid and muscimol

1968 • 208 citations

Synaptic localization of kainic acid binding sites

1981 • 195 citations

Structure-activity relations for the neurotoxicity of kainic acid derivatives and glutamate analogues

1978 • 182 citations

A histological study of kainic acid-induced lesions in the rat brain

1978 • 166 citations

Comparative toxicity of kainic acid and other acidic amino acids toward rat hippocampal neurons

1981 • 160 citations

Kainate, N-methylaspartate and other excitatory amino acids increase calcium influx into rat brain cortex cells in vitro

1983 • 156 citations

Kainic acid: Neurophysiological and neurotoxic actions

1979 • 150 citations

S-glutamate: Its interactions with spinal neurons

1981 • 137 citations

Clinical, neuropathologic and pharmacologic aspects of Huntington's disease: Correlates with a new animal model

1977 • 121 citations

Chronic infusion of endogenous excitatory amino acids into rat striatum and hippocampus

1983 • 110 citations

QUINOLINIC ACID METABOLISM

1949 • 103 citations

Intrahippocampal kainic acid, seizures and local neuronal degeneration: Relationships assessed in unanesthetized rats

1982 • 98 citations

Intrahippocampal injections of ibotenic acid provide histological evidence for a neurotoxic mechanism different from kainic acid

1979 • 79 citations

EFFECTS OF KAINIC ACID ON ION DISTRIBUTION AND ATP LEVELS OF STRIATAL SLICES INCUBATED IN VITRO

1978 • 77 citations

Alteration in Neuronal‐Glial Metabolism of Glutamate by the Neurotoxin Kainic Acid

1982 • 72 citations

Pharmacology of excitatory amino acid receptors mediating the stimulation of rat cerebellar cyclic GMP levele

1980 • 61 citations

Kainic acid neurotoxicity and seizures

1981 • 52 citations

α-Amino-ω-phosphono carboxylates block ibotenate but not kainate neurotoxicity in rat hippocampus

1982 • 45 citations

QUINOLINIC ACID METABOLISM

1949 • 38 citations

Effect of anticonvulsant drugs on kainic acid-induced epileptiform activity

1982 • 37 citations

Neurotoxic action of methyltetrahydrofolate in rat cerebellum unrelated to direct activation of kainate receptors

1981 • 37 citations

Platelet Glutamate and Aspartate Uptake in Huntington's Disease

1981 • 35 citations

Characteristics of the amino acid receptor site mediating formation of cyclic adenosine 3',5'-monophosphate in mammalian brains.

1975 • 34 citations

Serotonergic denervation partially protects rat striatum from kainic acid toxicity

1982 • 29 citations

POSSIBLE PATHOGENESIS OF HUNTINGTON'S CHOREA AND A NEW APPROACH TO TREATMENT

2009 • 29 citations

The effects of intrahippocampal ibotenic acid and their blockade by (?) 2-amino-7-phosphonoheptanoic acid: Morphological and electroencephalographical analysis

1983 • 28 citations

Evidence against an exclusive role of glutamate in kainic acid neurotoxicity

1980 • 27 citations

Glial fibrillary changes induced by kainic acid in organotypic culture of the rat cerebellum

1982 • 7 citations

Deleted Work

1955 • 0 citations