The brain-derived neurotrophic factor Val66Met polymorphism is associated with age-related change in reasoning skills

“Mini-mental state”

1975 • 82,784 citations

Manual for Raven's progressive matrices and vocabulary scales

1998 • 4,049 citations

Human Cognitive Abilities

1993 • 3,772 citations

The BDNF val66met Polymorphism Affects Activity-Dependent Secretion of BDNF and Human Memory and Hippocampal Function

2003 • 3,746 citations

Human Cognitive Abilities: A Survey of Factor-Analytic Studies

2009 • 3,341 citations

Wechsler Memory Scale-Revised

1987 • 2,327 citations

Wechsler memory scale-revised

1988 • 2,058 citations

Brain-Derived Neurotrophic Factor val⁶⁶met Polymorphism Affects Human Memory-Related Hippocampal Activity and Predicts Memory Performance

2003 • 1,022 citations

Evidence that brain‐derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice

2002 • 932 citations

BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease

1991 • 887 citations

The Brain-Derived Neurotrophic Factor val66met Polymorphism and Variation in Human Cortical Morphology

2004 • 878 citations

Variant Brain-Derived Neurotrophic Factor (BDNF) (Met66) Alters the Intracellular Trafficking and Activity-Dependent Secretion of Wild-Type BDNF in Neurosecretory Cells and Cortical Neurons

2004 • 862 citations

Brain-derived neurotrophic factor in the control human brain, and in Alzheimer’s disease and Parkinson’s disease

2001 • 851 citations

The Impact of Childhood Intelligence on Later Life: Following Up the Scottish Mental Surveys of 1932 and 1947.

2004 • 803 citations

From Acquisition to Consolidation: On the Role of Brain-Derived Neurotrophic Factor Signaling in Hippocampal-Dependent Learning

2002 • 667 citations

Essential role of brain-derived neurotrophic factor in adult hippocampal function

2004 • 653 citations

Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus

2002 • 570 citations

Brain-derived neurotrophic factor is reduced in Alzheimer's disease

1997 • 551 citations

Biosynthesis and Post-translational Processing of the Precursor to Brain-derived Neurotrophic Factor

2001 • 538 citations

The Stability of Individual Differences in Mental Ability from Childhood to Old Age: Follow-up of the 1932 Scottish Mental Survey

2000 • 505 citations

Modification of Brain Aging and Neurodegenerative Disorders by Genes, Diet, and Behavior

2002 • 436 citations

BDNF and Full-length and Truncated TrkB Expression in Alzheimer Disease. Implications in Therapeutic Strategies

1999 • 387 citations

Brain-derived neurotrophic factor Val66met polymorphism and volume of the hippocampal formation

2005 • 375 citations

Physiology of BDNF: focus on hypothalamic function

2004 • 360 citations

What needs to be explained to account for age-related effects on multiple cognitive variables?

2003 • 356 citations

Quantitation of BDNF mRNA in human parietal cortex by competitive reverse transcription-polymerase chain reaction: decreased levels in Alzheimer's disease

2000 • 316 citations

Cognitive change and the APOE ɛ4 allele

2002 • 297 citations

Achieving and Maintaining Cognitive Vitality With Aging

2002 • 288 citations

Differential regulation of Brain Derived Neurotrophic Factor transcripts by antidepressant treatments in the adult rat brain

2003 • 274 citations

A novel polymorphism of the brain-derived neurotrophic factor (BDNF) gene associated with late-onset Alzheimer's disease

2000 • 217 citations

Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's Disease

2005 • 217 citations

Association between BDNF val⁶⁶ met genotype and episodic memory

2005 • 174 citations

A new brain‐derived neurotrophic factor transcript and decrease inbrain‐derived neurotrophic factor transcripts 1, 2 and 3 in Alzheimer's disease parietal cortex

2002 • 138 citations

Factor Analysis of Four Measures of Prefrontal Lobe Functioning

1998 • 130 citations

Genetic and Environmental Contributions to General Cognitive Ability Through the First 16 Years of Life.

2004 • 110 citations

Association between genotype at an exonic SNP in DISC1 and normal cognitive aging

2005 • 107 citations

Association Study of a Brain-Derived Neurotrophic Factor (BDNF) Val66Met Polymorphism and Personality Trait and Intelligence in Healthy Young Females

2004 • 105 citations

Factor Analysis of Four Measures of Prefrontal Lobe Functioning

1998 • 98 citations

A polymorphism of the brain-derived neurotrophic factor (BDNF) is associated with Alzheimer's disease in patients lacking the Apolipoprotein E ε4 allele

2002 • 97 citations

Brain-derived neurotrophic factor gene polymorphisms and Alzheimer?s disease

2004 • 97 citations

The functional COMT polymorphism, Val158Met, is associated with logical memory and the personality trait intellect/imagination in a cohort of healthy 79 year olds

2005 • 89 citations

KLOTHO genotype and cognitive ability in childhood and old age in the same individuals

2005 • 88 citations

The Trend of Scottish Intelligence: A Comparison of the 1947 and 1932 Surveys of the Intelligence of Eleven-year-old Pupils.

1950 • 86 citations

Searching for genetic influences on normal cognitive ageing

2004 • 85 citations

Association Analysis of Brain-Derived Neurotrophic Factor Val66Met Polymorphisms with Alzheimer’s Disease and Age of Onset

2004 • 81 citations

Changes in BDNF-immunoreactive structures in the hippocampal formation of the aged macaque monkey

2001 • 80 citations

Apolipoprotein E Gene Variability and Cognitive Functions at Age 79: A Follow-Up of the Scottish Mental Survey of 1932.

2004 • 73 citations

Polymorphism at Codon 66 of the Brain-Derived Neurotrophic Factor Gene Is Not Associated with Sporadic Alzheimer’s Disease

2004 • 68 citations

Childhood IQ, smoking, and cognitive change from age 11 to 64 years

2004 • 66 citations

Brain-derived neurotrophic factor, apolipoprotein E genetic variants and cognitive performance in Alzheimer’s disease

2004 • 56 citations

Genetic influences on oxidative stress and their association with normal cognitive ageing

2005 • 50 citations

Association analysis of brain-derived neurotrophic factor (BDNF) gene 196 A/G polymorphism with Alzheimer's disease (AD) in mainland Chinese

2005 • 47 citations

The Genetic and Environmental Relationship Between General and Specific Cognitive Abilities in Twins Age 80 and Older

1998 • 38 citations

Genetic variation in the brain derived neurotrophic factor gene in Alzheimer's disease

2005 • 36 citations

Association of partial epilepsy with brain-derived neurotrophic factor (BDNF) gene polymorphisms

2003 • 36 citations

Lack of association between polymorphisms in angiotensin-converting-enzyme and methylenetetrahydrofolate reductase genes and normal cognitive ageing in humans

2003 • 35 citations

Age at natural menopause and cognition

2004 • 33 citations

Nicastrin gene polymorphisms, cognitive ability level and cognitive ageing

2004 • 27 citations

Association analysis of brain-derived neurotrophic factor （BDNF） gene 196 A/G polymorphism with Alzheimer＇s disease （AD） in mainland Chinese

2006 • 5 citations

Deleted Work

1955 • 0 citations