Localization of checkpoint and repair proteins in eukaryotes

The DNA damage response: putting checkpoints in perspective

2000 • 3,147 citations

A DNA damage checkpoint response in telomere-initiated senescence

2003 • 2,600 citations

Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

2003 • 2,569 citations

Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo

1999 • 2,380 citations

Cell cycle checkpoint signaling through the ATM and ATR kinases

2001 • 1,962 citations

Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

1997 • 1,466 citations

Genomic Instability in Mice Lacking Histone H2AX

2002 • 1,343 citations

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures

2000 • 1,236 citations

Pathways of DNA Double-Strand Break Repair during the Mammalian Cell Cycle

2003 • 1,157 citations

Histone H2AX Is Phosphorylated in an ATR-dependent Manner in Response to Replicational Stress

2001 • 1,109 citations

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

1997 • 1,055 citations

Requirement of the MRN complex for ATM activation by DNA damage

2003 • 1,043 citations

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

2003 • 968 citations

Role ofRAD52Epistasis Group Genes in Homologous Recombination and Double-Strand Break Repair

2002 • 962 citations

Choreography of the DNA Damage Response

2004 • 881 citations

The BRCT Domain Is a Phospho-Protein Binding Domain

2003 • 821 citations

Fork Reversal and ssDNA Accumulation at Stalled Replication Forks Owing to Checkpoint Defects

2002 • 805 citations

Recombination Proteins in Yeast

2004 • 788 citations

Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks

2004 • 750 citations

The DNA replication checkpoint response stabilizes stalled replication forks

2001 • 740 citations

Cell Cycle and Genetic Requirements of Two Pathways of Nonhomologous End-Joining Repair of Double-Strand Breaks in Saccharomyces cerevisiae

1996 • 733 citations

Direct Activation of the ATM Protein Kinase by the Mre11/Rad50/Nbs1 Complex

2004 • 724 citations

Interfaces Between the Detection, Signaling, and Repair of DNA Damage

2002 • 693 citations

BRCA2 Function in DNA Binding and Recombination from a BRCA2-DSS1-ssDNA Structure

2002 • 679 citations

Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint

2001 • 654 citations

S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex

2003 • 645 citations

BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

2003 • 644 citations

Stable Interaction between the Products of the BRCA1 and BRCA2 Tumor Suppressor Genes in Mitotic and Meiotic Cells

1998 • 625 citations

DNA helicase Srs2 disrupts the Rad51 presynaptic filament

2003 • 618 citations

The Srs2 helicase prevents recombination by disrupting Rad51 nucleoprotein filaments

2003 • 606 citations

Genomic Expression Responses to DNA-damaging Agents and the Regulatory Role of the Yeast ATR Homolog Mec1p

2001 • 556 citations

Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes.

1995 • 556 citations

Function of Yeast Rad52 Protein as a Mediator between Replication Protein A and the Rad51 Recombinase

1997 • 551 citations

The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair

2002 • 547 citations

Yeast Rad55 and Rad57 proteins form a heterodimer that functions with replication protein A to promote DNA strand exchange by Rad51 recombinase.

1997 • 536 citations

Control of the DNA Damage Checkpoint by Chk1 and Rad53 Protein Kinases Through Distinct Mechanisms

1999 • 535 citations

RAD51 Interacts with the Evolutionarily Conserved BRC Motifs in the Human Breast Cancer Susceptibility Gene brca2

1997 • 531 citations

XRCC2 and XRCC3, New Human Rad51-Family Members, Promote Chromosome Stability and Protect against DNA Cross-Links and Other Damages

1998 • 530 citations

Chromosome Instability and Defective Recombinational Repair in Knockout Mutants of the Five Rad51 Paralogs

2001 • 519 citations

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

2000 • 500 citations

Frequent chromosomal translocations induced by DNA double-strand breaks

2000 • 498 citations

Human Rad50/Mre11 Is a Flexible Complex that Can Tether DNA Ends

2001 • 493 citations

Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin

2002 • 492 citations

The Mre11 complex is required for ATM activation and the G2/M checkpoint

2003 • 489 citations

RecA homologs Dmc1 and Rad51 interact to form multiple nuclear complexes prior to meiotic chromosome synapsis

1994 • 479 citations

Dynamics of DNA Double-Strand Breaks Revealed by Clustering of Damaged Chromosome Domains

2004 • 466 citations

Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage

2003 • 463 citations

Stimulation by Rad52 of yeast Rad51- mediated recombination

1998 • 459 citations

A unified view of the DNA-damage checkpoint

2002 • 458 citations

Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway

1998 • 453 citations

Rad52 forms DNA repair and recombination centers during S phase

2001 • 452 citations

The Nuclease Activity of Mre11 Is Required for Meiosis but Not for Mating Type Switching, End Joining, or Telomere Maintenance

1999 • 443 citations

Specialized DNA Polymerases, Cellular Survival, and the Genesis of Mutations

2002 • 441 citations

Colocalization of multiple DNA double-strand breaks at a single Rad52 repair centre

2003 • 421 citations

Replication protein A-mediated recruitment and activation of Rad17 complexes

2003 • 416 citations

The Mre11 Complex Is Required for Repair of Hairpin-Capped Double-Strand Breaks and Prevention of Chromosome Rearrangements

2002 • 395 citations

Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention

2004 • 395 citations

Rad53 FHA Domain Associated with Phosphorylated Rad9 in the DNA Damage Checkpoint

1998 • 392 citations

DNA Damage-Dependent Nuclear Dynamics of the Mre11 Complex

2001 • 392 citations

Werner's syndrome protein (WRN) migrates Holliday junctions and co‐localizes with RPA upon replication arrest

2000 • 385 citations

A DNA Damage Response Pathway Controlled by Tel1 and the Mre11 Complex

2001 • 384 citations

Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53

2003 • 375 citations

Identification and purification of two distinct complexes containing the five RAD51 paralogs

2001 • 374 citations

TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1

1995 • 370 citations

Repair of DNA double strand breaks by non-homologous end joining

2003 • 366 citations

Nuclear foci of mammalian recombination proteins are located at single-stranded DNA regions formed after DNA damage

1999 • 348 citations

An ATR- and Cdc7-Dependent DNA Damage Checkpoint that Inhibits Initiation of DNA Replication

2003 • 345 citations

DNA polymerase stabilization at stalled replication forks requires Mec1 and the RecQ helicase Sgs1

2003 • 333 citations

Recovery from Checkpoint-Mediated Arrest after Repair of a Double-Strand Break Requires Srs2 Helicase

2002 • 332 citations

Binding of double-strand breaks in DNA by human Rad52 protein

1999 • 314 citations

RAD51C Is Required for Holliday Junction Processing in Mammalian Cells

2004 • 309 citations

Budding Yeast Rad9 Is an ATP-Dependent Rad53 Activating Machine

2001 • 297 citations

Rescue of arrested replication forks by homologous recombination

2001 • 296 citations

A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage

2002 • 289 citations

The Dun1 checkpoint kinase phosphorylates and regulates the ribonucleotide reductase inhibitor Sml1

2002 • 289 citations

Dpb11, which interacts with DNA polymerase II(epsilon) in Saccharomyces cerevisiae, has a dual role in S-phase progression and at a cell cycle checkpoint.

1995 • 275 citations

Interaction of FANCD2 and NBS1 in the DNA damage response

2002 • 274 citations

Radiation-induced Assembly of Rad51 and Rad52 Recombination Complex Requires ATM and c-Abl

1999 • 272 citations

ATM-related Tel1 associates with double-strand breaks through an Xrs2-dependent mechanism

2003 • 272 citations

DNA Structure-specific Nuclease Activities in theSaccharomyces cerevisiae Rad50·Mre11 Complex

2001 • 271 citations

The yeast Sgs1p helicase acts upstream of Rad53p in the DNA replication checkpoint and colocalizes with Rad53p in S-phase-specific foci

2000 • 266 citations

Xrcc3 Is Required for Assembly of Rad51 Complexes in Vivo

1998 • 251 citations

Nuclear dynamics of RAD52 group homologous recombination proteins in response to DNA damage

2002 • 248 citations

Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein

2003 • 239 citations

Human Claspin Is Required for Replication Checkpoint Control

2003 • 232 citations

Yeast histone 2A serine 129 is essential for the efficient repair of checkpoint‐blind DNA damage

2003 • 224 citations

Regulation of Rad51 Function by c-Abl in Response to DNA Damage

1998 • 217 citations

BRCT Domain-containing Protein TopBP1 Functions in DNA Replication and Damage Response

2001 • 217 citations

Physical Interaction between Human RAD52 and RPA Is Required for Homologous Recombination in Mammalian Cells

1996 • 212 citations

Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways

2004 • 211 citations

BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination

2003 • 207 citations

Phosphorylation of the Bloom's Syndrome Helicase and Its Role in Recovery from S-Phase Arrest

2004 • 204 citations

UV-induced Ataxia-telangiectasia-mutated and Rad3-related (ATR) Activation Requires Replication Stress

2004 • 204 citations

Covalent protein-DNA complexes at the 5' strand termini of meiosis-specific double-strand breaks in yeast.

1995 • 200 citations

RAD9, RAD17, and RAD24 Are Required for S Phase Regulation in Saccharomyces cerevisiae in Response to DNA Damage

1997 • 198 citations

BRCA2-dependent and independent formation of RAD51 nuclear foci

2003 • 198 citations

53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage.

2003 • 196 citations

Evidence for Simultaneous Protein Interactions between Human Rad51 Paralogs

2000 • 195 citations

Specific Interactions between the Human RAD51 and RAD52 Proteins

1996 • 195 citations

Histone H2A Phosphorylation Controls Crb2 Recruitment at DNA Breaks, Maintains Checkpoint Arrest, and Influences DNA Repair in Fission Yeast

2004 • 194 citations

Interaction of human Rad51 recombination protein with single-stranded DNA binding protein, RPA

1998 • 192 citations

Transient Stability of DNA Ends Allows Nonhomologous End Joining to Precede Homologous Recombination

2002 • 191 citations

A DNA Damage-Regulated BRCT-Containing Protein, TopBP1, Is Required for Cell Survival

2002 • 187 citations

Functional Interactions among Yeast Rad51 Recombinase, Rad52 Mediator, and Replication Protein A in DNA Strand Exchange

2000 • 175 citations

DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination

2002 • 175 citations

Werner helicase relocates into nuclear foci in response to DNA damaging agents and co‐localizes with RPA and Rad51

2001 • 171 citations

Overlapping Functions of the Saccharomyces cerevisiae Mre11, Exo1 and Rad27 Nucleases in DNA Metabolism

2001 • 168 citations

Checkpoint-mediated control of replisome–fork association and signalling in response to replication pausing

2003 • 168 citations

Repair of topoisomerase I covalent complexes in the absence of the tyrosyl-DNA phosphodiesterase Tdp1

2002 • 165 citations

Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4^TOPBP1

2004 • 149 citations

DNA damage checkpoint and repair centers

2004 • 149 citations

Promotion of Rad51-dependent D-loop formation by yeast recombination factor Rdh54/Tid1

2000 • 146 citations

Sequestration of Mammalian Rad51-Recombination Protein into Micronuclei

1999 • 143 citations

Lack of chromosome territoriality in yeast: Promiscuous rejoining of broken chromosome ends

1996 • 139 citations

Studies of the Interaction between Rad52 Protein and the Yeast Single-Stranded DNA Binding Protein RPA

1998 • 138 citations

Rad52 partially substitutes for the Rad51 paralog XRCC3 in maintaining chromosomal integrity in vertebrate cells

2001 • 132 citations

DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae

1999 • 130 citations

Structure of DNA-dependent protein kinase: implications for its regulation by DNA

1999 • 127 citations

Saccharomyces cerevisiae Rrm3p DNA Helicase Promotes Genome Integrity by Preventing Replication Fork Stalling: Viability of rrm3 Cells Requires the Intra-S-Phase Checkpoint and Fork Restart Activities

2004 • 124 citations

Recruitment of the Cell Cycle Checkpoint Kinase ATR to Chromatin during S-phase

2004 • 122 citations

Werner's syndrome protein is phosphorylated in an ATR/ATM-dependent manner following replication arrest and DNA damage induced during the S phase of the cell cycle

2003 • 122 citations

Regulation of Genome Stability by TEL1 and MEC1, Yeast Homologs of the Mammalian ATM and ATR Genes

2002 • 118 citations

Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest

2002 • 118 citations

The Werner Syndrome Protein Stimulates DNA Polymerase β Strand Displacement Synthesis via Its Helicase Activity

2003 • 118 citations

RAD51 localization and activation following DNA damage

2004 • 111 citations

Switching from high-fidelity replicases to low-fidelity lesion-bypass polymerases

2004 • 110 citations

Mre11 Assembles Linear DNA Fragments into DNA Damage Signaling Complexes

2004 • 107 citations

Impaired DNA damage-induced nuclear Rad51 foci formation uniquely characterizes Fanconi anemia group D1

2002 • 104 citations

Enhancement of Saccharomyces cerevisiae End-Joining Efficiency by Cell Growth Stage but Not by Impairment of Recombination

2002 • 103 citations

Quaternary Structure of ATR and Effects of ATRIP and Replication Protein A on Its DNA Binding and Kinase Activities

2004 • 102 citations

XRCC2 Is a Nuclear RAD51-like Protein Required for Damage-dependent RAD51 Focus Formation without the Need for ATP Binding

2001 • 99 citations

Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks

2003 • 97 citations

Reciprocal Association of the Budding Yeast ATM-Related Proteins Tel1 and Mec1 with Telomeres In Vivo

2004 • 94 citations

Ionizing radiation-induced Rad51 nuclear focus formation is cell cycle-regulated and defective in both ATM−/− and c-Abl−/− cells

2003 • 89 citations

Direct Kinase-to-Kinase Signaling Mediated by the FHA Phosphoprotein Recognition Domain of the Dun1 DNA Damage Checkpoint Kinase

2003 • 87 citations

Independent Roles for Nibrin and Mre11-Rad50 in the Activation and Function of Atm

2004 • 86 citations

Functional Interaction between the Bloom's Syndrome Helicase and the RAD51 Paralog, RAD51L3 (RAD51D)

2003 • 86 citations

Interaction between BRCA2 and replication protein A is compromised by a cancer-predisposing mutation in BRCA2

2003 • 84 citations

Genetic and Physical Interactions Between DPB11 and DDC1 in the Yeast DNA Damage Response Pathway

2002 • 79 citations

Localization and dynamic relocalization of mammalian Rad52 during the cell cycle and in response to DNA damage

1999 • 71 citations

A domain of Rad9 specifically required for activation of Chk1 in budding yeast

2004 • 68 citations

Cell Cycle-Regulated Centers of DNA Double-Strand Break Repair

2003 • 68 citations

A Novel Human Rad54 Homologue, Rad54B, Associates with Rad51

2000 • 66 citations

Microhomology-Dependent End Joining and Repair of Transposon-Induced DNA Hairpins by Host Factors in Saccharomyces cerevisiae

2004 • 65 citations

Association of p53 and MSH2 with recombinative repair complexes during S phase

2002 • 57 citations

Regulation of Ionizing Radiation-induced Rad52 Nuclear Foci Formation by c-Abl-mediated Phosphorylation

2002 • 56 citations

Human Rad54B is a double-stranded DNA-dependent ATPase and has biochemical properties different from its structural homolog in yeast, Tid1/Rdh54

2002 • 56 citations

Molecular Anatomy of the DNA Damage and Replication Checkpoints

2003 • 54 citations

A Novel Protein Activity Mediates DNA Binding of an ATR-ATRIP Complex

2004 • 49 citations

Werner syndrome protein, the MRE11 complex and ATR: menage‐à‐trois in guarding genome stability during DNA replication?

2004 • 33 citations

Nuclear oscillations and nuclear filament formation accompany single-strand annealing repair of a dicentric chromosome in Saccharomyces cerevisiae

2002 • 30 citations