DNA polymerase stabilization at stalled replication forks requires Mec1 and the RecQ helicase Sgs1

Systematic Genetic Analysis with Ordered Arrays of Yeast Deletion Mutants

2001 • 2,139 citations

Three new dominant drug resistance cassettes for gene disruption inSaccharomyces cerevisiae

1999 • 1,793 citations

Replication Dynamics of the Yeast Genome

2001 • 811 citations

Fork Reversal and ssDNA Accumulation at Stalled Replication Forks Owing to Checkpoint Defects

2002 • 805 citations

Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair.

1994 • 759 citations

The DNA replication checkpoint response stabilizes stalled replication forks

2001 • 740 citations

A Suppressor of Two Essential Checkpoint Genes Identifies a Novel Protein that Negatively Affects dNTP Pools

1998 • 733 citations

Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint

2001 • 654 citations

A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication

1998 • 652 citations

A checkpoint regulates the rate of progression through S phase in S. cerevisiae in Response to DNA damage

1995 • 596 citations

A unified view of the DNA-damage checkpoint

2002 • 458 citations

Relocalization of Telomeric Ku and SIR Proteins in Response to DNA Strand Breaks in Yeast

1999 • 458 citations

Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway

1998 • 453 citations

ATR Homolog Mec1 Promotes Fork Progression, Thus Averting Breaks in Replication Slow Zones

2002 • 443 citations

Regulation of DNA-replication origins during cell-cycle progression

1998 • 415 citations

Two checkpoint complexes are independently recruited to sites of DNA damage in vivo

2001 • 387 citations

SGS1, a Homologue of the Bloom's and Werner's Syndrome Genes, Is Required for Maintenance of Genome Stability in Saccharomyces cerevisiae

1996 • 380 citations

Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase

1999 • 376 citations

Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicases

2000 • 358 citations

rqh1+, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest

1997 • 354 citations

An ATR- and Cdc7-Dependent DNA Damage Checkpoint that Inhibits Initiation of DNA Replication

2003 • 345 citations

Checking on the fork: the DNA-replication stress-response pathway

2002 • 340 citations

SGS1, the Saccharomyces cerevisiae homologue of BLM and WRN, suppresses genome instability and homeologous recombination

2001 • 320 citations

Functional and Physical Interaction between WRN Helicase and Human Replication Protein A

1999 • 302 citations

Bloom’s and Werner’s syndrome genes suppress hyperrecombination in yeast sgs1 mutant: Implication for genomic instability in human diseases

1998 • 298 citations

DNA Polymerase ε Catalytic Domains Are Dispensable for DNA Replication, DNA Repair, and Cell Viability

1999 • 276 citations

The yeast Sgs1p helicase acts upstream of Rad53p in the DNA replication checkpoint and colocalizes with Rad53p in S-phase-specific foci

2000 • 266 citations

Homologous Recombination Resolution Defect in Werner Syndrome

2002 • 255 citations

Recruitment of Mec1 and Ddc1 Checkpoint Proteins to Double-Strand Breaks Through Distinct Mechanisms

2001 • 253 citations

Differential assembly of Cdc45p and DNA polymerases at early and late origins of DNA replication

1999 • 241 citations

ORC and the intra-S-phase checkpoint: a threshold regulates Rad53p activation in S phase

2002 • 212 citations

Analysis of the Essential Functions of the C-terminal Protein/Protein Interaction Domain of Saccharomyces cerevisiae pol ε and Its Unexpected Ability to Support Growth in the Absence of the DNA Polymerase Domain

1999 • 202 citations

RAD9, RAD17, and RAD24 Are Required for S Phase Regulation in Saccharomyces cerevisiae in Response to DNA Damage

1997 • 198 citations

Role of Schizosaccharomyces pombe RecQ Homolog, Recombination, and Checkpoint Genes in UV Damage Tolerance

1997 • 189 citations

The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast

1996 • 187 citations

RecQ family helicases: roles in cancer and aging

2000 • 186 citations

Dpb11 Controls the Association between DNA Polymerases α and ɛ and the Autonomously Replicating Sequence Region of Budding Yeast

2000 • 183 citations

Purification and Characterization of the Sgs1 DNA Helicase Activity of Saccharomyces cerevisiae

1998 • 170 citations

Is the MCM2–7 complex the eukaryotic DNA replication fork helicase?

2001 • 159 citations

Association of RPA with chromosomal replication origins requires an Mcm protein, and is regulated by Rad53, and cyclin- and Dbf4-dependent kinases

1998 • 155 citations

Suppression of genome instability by redundant S-phase checkpoint pathways in Saccharomyces cerevisiae

2002 • 146 citations

A role for the Cdc7 kinase regulatory subunit Dbf4p in the formation of initiation-competent origins of replication

1999 • 120 citations

Time of Replication of ARS Elements along Yeast Chromosome III

1989 • 115 citations

Cell cycle regulation of the endogenous wild type Bloom's syndrome DNA helicase

2000 • 110 citations

The yeast Sgs1 helicase is differentially required for genomic and ribosomal DNA replication

2003 • 105 citations

Phosphorylation of the replication protein A large subunit in the Saccharomyces cerevisiae checkpoint response

2000 • 95 citations

Bloom's syndrome gene suppresses premature ageing caused by Sgs1 deficiency in yeast

1999 • 89 citations

Elevation of sister chromatid exchange in Saccharomyces cerevisiae sgs1 disruptants and the relevance of the disruptants as a system to evaluate mutations in Bloom's syndrome gene

2000 • 84 citations

A single unbranched S-phase DNA damage and replication fork blockage checkpoint pathway

2002 • 74 citations

Functions of RecQ Family Helicases: Possible Involvement of Bloom's and Werner's Syndrome Gene Products in Guarding Genome Integrity during DNA Replication

2001 • 55 citations

Importance of the Sgs1 helicase activity in DNA repair of Saccharomyces cerevisiae

2000 • 43 citations

RecQ helicases and genome stability: lessons from model organisms and human disease

2002 • 23 citations