A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage

DNA Repair and Mutagenesis

2006 • 4,725 citations

Functional Characterization of the S. cerevisiae Genome by Gene Deletion and Parallel Analysis

1999 • 3,929 citations

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

2002 • 3,624 citations

Getting started with yeast

2002 • 3,496 citations

Designer deletion strains derived fromSaccharomyces cerevisiae S288C: A useful set of strains and plasmids for PCR-mediated gene disruption and other applications

1998 • 3,373 citations

[1] Getting started with yeast

1991 • 2,456 citations

Systematic Genetic Analysis with Ordered Arrays of Yeast Deletion Mutants

2001 • 2,139 citations

Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents

1990 • 880 citations

Overview of manual and automated DNA sequencing by the dideoxy chain termination method

1991 • 840 citations

Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair.

1994 • 759 citations

Thymine-Thymine Dimer Bypass by Yeast DNA Polymerase ζ

1996 • 655 citations

Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint

2001 • 654 citations

GeneCards: integrating information about genes, proteins and diseases

1997 • 644 citations

DNA damage-inducible transcripts in mammalian cells.

1988 • 613 citations

A checkpoint regulates the rate of progression through S phase in S. cerevisiae in Response to DNA damage

1995 • 596 citations

Genomic Expression Responses to DNA-damaging Agents and the Regulatory Role of the Yeast ATR Homolog Mec1p

2001 • 556 citations

The RCAF complex mediates chromatin assembly during DNA replication and repair

1999 • 539 citations

Mus81-Eme1 Are Essential Components of a Holliday Junction Resolvase

2001 • 526 citations

Induction of cellular p53 activity by DNA-damaging agents and growth arrest.

1993 • 440 citations

Global response of Saccharomyces cerevisiae to an alkylating agent

1999 • 426 citations

Requirement for Three Novel Protein Complexes in the Absence of the Sgs1 DNA Helicase in Saccharomyces cerevisiae

2001 • 397 citations

Developmental Control of Cell Cycle Regulators: A Fly's Perspective

1996 • 383 citations

Ultraviolet radiation sensitivity and reduction of telomeric silencing in Saccharomyces cerevisiae cells lacking chromatin assembly factor-I.

1997 • 382 citations

MUTATIONS AFFECTING TY-MEDIATED EXPRESSION OF THE HIS4 GENE OF SACCHAROMYCES CEREVISIAE

1984 • 355 citations

YPDTM, PombePDTM and WormPDTM: model organism volumes of the BioKnowledgeTM Library, an integrated resource for protein information

2001 • 329 citations

Genes required for ionizing radiation resistance in yeast

2001 • 317 citations

Functional overlap between Sgs1–Top3 and the Mms4–Mus81 endonuclease

2001 • 315 citations

Identification of RFC(Ctf18p, Ctf8p, Dcc1p)

2001 • 314 citations

Saccharomyces cerevisiaeCTF18 and CTF4 Are Required for Sister Chromatid Cohesion

2001 • 303 citations

DNA REPAIR GENES AND PROTEINS OF SACCHAROMYCES CEREVISIAE

1993 • 301 citations

Damage Tolerance Protein Mus81 Associates with the FHA1 Domain of Checkpoint Kinase Cds1

2000 • 284 citations

The Mre11-Rad50-Xrs2 Protein Complex Facilitates Homologous Recombination-Based Double-Strand Break Repair in Saccharomyces cerevisiae

1999 • 267 citations

Sensing and responding to DNA damage

2000 • 264 citations

Human Mus81-Associated Endonuclease Cleaves Holliday Junctions In Vitro

2001 • 261 citations

DNA postreplication repair and mutagenesis in Saccharomyces cerevisiae

2001 • 249 citations

Transcriptional response of Saccharomyces cerevisiae to DNA-damaging agents does not identify the genes that protect against these agents

2002 • 246 citations

Methylation of the O⁶Position of Guanine in DNA is the Most Likely Initiating Event in Carcinogenesis by Methylating Agents

1984 • 236 citations

A Rad52 homolog is required for RAD51-independent mitotic recombination in Saccharomyces cerevisiae.

1996 • 234 citations

The yeast Xrs2 complex functions in S phase checkpoint regulation

2001 • 225 citations

MUS81 encodes a novel Helix-hairpin-Helix protein involved in the response to UV- and methylation-induced DNA damage in Saccharomyces cerevisiae

2000 • 221 citations

Identification of new genes required for meiotic recombination in Saccharomyces cerevisiae.

1993 • 218 citations

The Yeast Proteome Database (YPD): a model for the organization and presentation of genome-wide functional data

1999 • 217 citations

ISOLATION AND CHARACTERIZATION OF MMS-SENSITIVE MUTANTS OF SACCHAROMYCES CEREVISIAE

1977 • 216 citations

Yeast Rad54 Promotes Rad51-dependent Homologous DNA Pairing via ATP Hydrolysis-driven Change in DNA Double Helix Conformation

1999 • 209 citations

RAD9, RAD17, and RAD24 Are Required for S Phase Regulation in Saccharomyces cerevisiae in Response to DNA Damage

1997 • 198 citations

RADH, a gene ofSaccharomyces cerevisiaeencoding a putative DNA helicase involved in DNA repair. Characteristics of radH mutants and sequence of the gene

1989 • 194 citations

Dynamic Interaction of DNA Damage Checkpoint Protein Rad53 with Chromatin Assembly Factor Asf1

2001 • 186 citations

Checkpoint activation in response to double-strand breaks requires the Mre11/Rad50/Xrs2 complex

2001 • 186 citations

A genome-wide screen in Saccharomyces cerevisiae for genes affecting UV radiation sensitivity

2001 • 180 citations

A chemical genomics approach toward understanding the global functions of the target of rapamycin protein (TOR)

2000 • 171 citations

Conditional Lethality of Null Mutations in RTH1 That Encodes the Yeast Counterpart of a Mammalian 5′- to 3′-Exonuclease Required for Lagging Strand DNA Synthesis in Reconstituted Systems

1995 • 168 citations

The Saccharomyces cerevisiae RAD6 Group Is Composed of an Error-Prone and Two Error-Free Postreplication Repair Pathways

2000 • 157 citations

The novel DNA damage checkpoint protein Ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast

1997 • 147 citations

Saccharomyces cerevisiae 3-methyladenine DNA glycosylase has homology to the AlkA glycosylase of E. coli and is induced in response to DNA alkylation damage.

1990 • 144 citations

Multiple pathways for homologous recombination in Saccharomyces cerevisiae.

1995 • 142 citations

Requirement of Yeast SGS1 and SRS2 Genes for Replication and Transcription

1999 • 142 citations

Fidelity of Mitotic Double-Strand-Break Repair in Saccharomyces cerevisiae: A Role for SAE2/COM1

2001 • 141 citations

3-Methyladenine residues in DNA induce the SOS function sfiA in Escherichia coli.

1984 • 136 citations

Cloning a eukaryotic DNA glycosylase repair gene by the suppression of a DNA repair defect in Escherichia coli.

1989 • 124 citations

HPR1, a novel yeast gene that prevents intrachromosomal excision recombination, shows carboxy-terminal homology to the Saccharomyces cerevisiae TOP1 gene.

1990 • 124 citations

Fission yeast Rad50 stimulates sister chromatid recombination and links cohesion with repair

2001 • 122 citations

Chl12 (Ctf18) Forms a Novel Replication Factor C-Related Complex and Functions Redundantly with Rad24 in the DNA Replication Checkpoint Pathway

2001 • 117 citations

Previously uncharacterized genes in the UV- and MMS-induced DNA damage response in yeast

2002 • 112 citations

POL32 , a subunit of the Saccharomyces cerevisiae DNA polymerase δ, defines a link between DNA replication and the mutagenic bypass repair pathway

2000 • 107 citations

Mutations in Recombinational Repair and in Checkpoint Control Genes Suppress the Lethal Combination of srs2Δ With Other DNA Repair Genes in Saccharomyces cerevisiae

2001 • 107 citations

Bdf1, a Yeast Chromosomal Protein Required for Sporulation

1995 • 107 citations

Mapping the DNA Topoisomerase III Binding Domain of the Sgs1 DNA Helicase

2001 • 97 citations

The repair of DNA methylation damage in Saccharomyces cerevisiae

1996 • 96 citations

Cloning and expression in Escherichia coli of a gene for an alkylbase DNA glycosylase from Saccharomyces cerevisiae; a homologue to the bacterial alkA gene.

1990 • 84 citations

Distinct roles of yeast MEC and RAD checkpoint genes in transcriptional induction after DNA damage and implications for function.

1996 • 81 citations

Genetic and Physical Interactions Between DPB11 and DDC1 in the Yeast DNA Damage Response Pathway

2002 • 79 citations

Role of Saccharomyces cerevisiae Chromatin Assembly Factor-I in Repair of Ultraviolet Radiation Damage in Vivo

1999 • 78 citations

Mutagens as carcinogens: development of current concepts

1989 • 76 citations

The Saccharomyces repair genes at the end of the century

2000 • 74 citations

Protective role of superoxide dismutases against ionizing radiation in yeast

2001 • 73 citations

Synergism between base excision repair, mediated by the DNA glycosylases Ntg1 and Ntg2, and nucleotide excision repair in the removal of oxidatively damaged DNA bases in Saccharomyces cerevisiae

2001 • 71 citations

Monofunctional alkylating agent-induced S-phase-dependent DNA damage

1989 • 70 citations

Topoisomerase III Acts Upstream of Rad53p in the S-Phase DNA Damage Checkpoint

2001 • 69 citations

Review

1997 • 69 citations

Synergism between yeast nucleotide and base excision repair pathways in the protection against DNA methylation damage

1998 • 66 citations

The RAD5 gene product is involved in the avoidance of non-homologous end-joining of DNA double strand breaks in the yeast Saccharomyces cerevisiae

1997 • 59 citations

Dual Requirement for the YeastMMS19Gene in DNA Repair and RNA Polymerase II Transcription

1996 • 57 citations

Relationships between yeast Rad27 and Apn1 in response to apurinic/apyrimidinic (AP) sites in DNA

1999 • 57 citations

Yeast Ty1 Retrotransposition Is Stimulated by a Synergistic Interaction between Mutations in Chromatin Assembly Factor I and Histone Regulatory Proteins

1998 • 57 citations

Bleomycin-induced mutation and recombination in Saccharomyces cerevisiae

1978 • 56 citations

The yeastSaccharomyces cerevisiaeDNA polymerase IV: possible involvement in double strand break DNA repair

1994 • 55 citations

A Conserved Domain of Schizosaccharomyces pombe dfp1⁺ Is Uniquely Required for Chromosome Stability following Alkylation Damage during S Phase

2002 • 54 citations

MMS1 protects against replication-dependent DNA damage in Saccharomyces cerevisiae

2002 • 41 citations

Induction of Cellular p53 Activity by DNA-Damaging Agents and Growth Arrest

1993 • 40 citations

HPR1, a Novel Yeast Gene That Prevents Intrachromosomal Excision Recombination, Shows Carboxy-Terminal Homology to the Saccharomyces cerevisiae TOP1 Gene

1990 • 38 citations

Eukaryotic mutagenesis and translesion replication dependent on DNA polymerase ζ and Rev I protein

2001 • 38 citations

Protein kinases and the response to DNA damage

1994 • 36 citations

Using Yeast to Understand Drugs that Target Topoisomerases^a

1996 • 33 citations

Mutations in the Yeast SRB2 General Transcription Factor Suppress hpr1-Induced Recombination and Show Defects in DNA Repair

1996 • 29 citations

Radiosensitive and Mitotic Recombination Phenotypes of the Saccharomyces cerevisiae dun1 Mutant Defective in DNA Damage-Inducible Gene Expression

1999 • 28 citations

The RAD24 (= Rs 1) Gene Product of Saccharomyces cerevisiae Participates in Two Different Pathways of DNA Repair

1987 • 27 citations

Eukaryotic mutagenesis and translesion replication dependent on DNA polymerase ζ and Rev1 protein

2001 • 10 citations

<scp>XIII</scp>. Yeast mapping reports. The RAD58 (XRS4) gene: Map position on the right arm of chromosome XIII

1995 • 8 citations

CROSS SENSITIVITY OF MUTATOR STRAINS TO PHYSICAL AND CHEMICAL MUTAGENS

1979 • 6 citations