Notes: Cell-Specific Activity of cis-Acting Regulatory Elements in the Promoter of the Mouse Multidrug Resistance Gene mdr1

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.

1987 • 4,937 citations

CpG Islands in vertebrate genomes

1987 • 3,315 citations

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

1982 • 3,106 citations

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Regulation of Inducible and Tissue-Specific Gene Expression

1987 • 1,640 citations

Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain

1987 • 1,640 citations

Fos and jun: The AP-1 connection

1988 • 1,597 citations

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

1987 • 1,080 citations

Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

1986 • 1,058 citations

Oligonucleotide-Directed Mutagenesis: A Simple Method Using Two Oligonucleotide Primers and a Single-Stranded DNA Template

1984 • 947 citations

Isolation and expression of a complementary DNA that confers multidrug resistance

1986 • 808 citations

Two distinct transcription factors bind to the HSV thymidine kinase promoter in vitro

1985 • 805 citations

The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues.

1989 • 467 citations

Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities.

1990 • 420 citations

Detection of P-glycoprotein isoforms by gene-specific monoclonal antibodies.

1990 • 386 citations

Compilation and analysis of eukaryotic POL II promoter sequences

1986 • 345 citations

Sequence of mdr3 cDNA encoding a human P-glycoprotein

1988 • 292 citations

The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus.

1988 • 270 citations

Cloning and characterization of a second member of the mouse mdr gene family.

1988 • 268 citations

The human oxytocin gene promoter is regulated by estrogens.

1990 • 241 citations

Negative control of liver-specific gene expression: cloned human retinol-binding protein gene is repressed in HeLa cells.

1987 • 138 citations

A combination of closely associated positive and negative cis-acting promoter elements regulates transcription of the skeletal alpha-actin gene.

1990 • 124 citations

Multiple nuclear proteins in liver cells are bound to hepatitis B virus enhancer element and its upstream sequences.

1987 • 119 citations

Identification of positive and negative regulatory elements governing cell-type-specific expression of the neural cell adhesion molecule gene.

1990 • 114 citations

Multidrug resistance gene expression is controlled by steroid hormones in the secretory epithelium of the uterus

1990 • 103 citations

The Three Mouse Multidrug Resistance (mdr) Genes Are Expressed in a Tissue-Specific Manner in Normal Mouse Tissues

1989 • 90 citations

Simultaneous expression of two P-glycoprotein genes in drug-sensitive Chinese hamster ovary cells.

1987 • 84 citations

Two Members of the Mouse mdr Gene Family Confer Multidrug Resistance with Overlapping but Distinct Drug Specificities

1990 • 69 citations

Mammalian multidrug-resistance gene: correlation of exon organization with structural domains and duplication of an ancestral gene.

1989 • 62 citations