Conditional gene targeting.

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

1987 • 2,368 citations

Inducible Gene Targeting in Mice

1995 • 1,897 citations

Deletion of a DNA Polymerase β Gene Segment in T Cells Using Cell Type-Specific Gene Targeting

1994 • 1,396 citations

Acre-transgenic mouse strain for the ubiquitous deletion ofloxP-flanked gene segments including deletion in germ cells

1995 • 1,269 citations

Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1.

1988 • 1,180 citations

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

1993 • 984 citations

Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter.

1994 • 777 citations

Bacteriophage P1 site-specific recombination

1981 • 762 citations

Targeted oncogene activation by site-specific recombination in transgenic mice.

1992 • 687 citations

Impairment of T-cell-dependent B-cell responses and B-l cell development in CD19-deficient mice

1995 • 663 citations

Tissue- and site-specific DNA recombination in transgenic mice.

1992 • 651 citations

The new mouse genetics: Altering the genome by gene targeting

1989 • 608 citations

Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase.

1995 • 562 citations

The integrase family of site-specific recombinases: regional similarities and global diversity.

1986 • 515 citations

Chromosome engineering in mice

1995 • 479 citations

Rescue of the En-1 Mutant Phenotype by Replacement of En-1 with En-2

1995 • 402 citations

Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells

1991 • 338 citations

Studies on the properties of P1 site-specific recombination: Evidence for topologically unlinked products following recombination

1983 • 327 citations

P1 site-specific recombination: nucleotide sequence of the recombining sites.

1982 • 326 citations

Aberrant B Cell Development and Immune Response in Mice with a Compromised BCR Complex

1996 • 290 citations

Inducible Site-Directed Recombination in Mouse Embryonic Stem Cells

1996 • 286 citations

Regulation of Cre recombinase activity by the synthetic steroid RU 486

1996 • 276 citations

T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination.

1995 • 266 citations

Altering Genes in Animals by Gene Targeting

1992 • 224 citations

Testing an "in-out" targeting procedure for making subtle genomic modifications in mouse embryonic stem cells.

1991 • 179 citations

Site-specific recombination by the bacteriophage P1 lox-Cre system

1984 • 125 citations

Use of double-replacement gene targeting to replace the murine alpha-lactalbumin gene with its human counterpart in embryonic stem cells and mice.

1994 • 115 citations

Efficient control of gene expression by single step integration of the tetracycline system in transgenic mice

1996 • 112 citations

Double replacement: strategy for efficient introduction of subtle mutations into the murine Col1a-1 gene by homologous recombination in embryonic stem cells.

1994 • 109 citations

Cre-loxP-mediated gene replacement: a mouse strain producing humanized antibodies

1994 • 101 citations

Testing an “In-Out” Targeting Procedure for Making Subtle Genomic Modifications in Mouse Embryonic Stem Cells

1991 • 46 citations

Use of Double-Replacement Gene Targeting to Replace the Murine α-Lactalbumin Gene with Its Human Counterpart in Embryonic Stem Cells and Mice

1994 • 28 citations

Altering Genes In Animals By Gene Targeting

1992 • 9 citations