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2003 • 5,952 citations

The Inflammasome

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Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+

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Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

2000 • 3,241 citations

The lineage decisions of helper T cells

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Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock

1995 • 1,413 citations

Viruses and interferon: a fight for supremacy

2002 • 1,335 citations

Coupling endoplasmic reticulum stress to the cell death program

2004 • 1,172 citations

Cross-Talk between Two Cysteine Protease Families

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An Endoplasmic Reticulum Stress-specific Caspase Cascade in Apoptosis

2002 • 875 citations

An improved colorimetric assay for interleukin 2

1986 • 858 citations

Proteases for Cell Suicide: Functions and Regulation of Caspases

2000 • 720 citations

Murine Caspase-11, an ICE-Interacting Protease, Is Essential for the Activation of ICE

1998 • 687 citations

Coupling Endoplasmic Reticulum Stress to the Cell Death Program

2001 • 584 citations

Dual Signaling of the Fas Receptor: Initiation of Both Apoptotic and Necrotic Cell Death Pathways

1998 • 553 citations

Interleukin‐1β, Interleukin‐18, and the Interleukin‐1β Converting Enzyme^a

1998 • 495 citations

The interferon-α/β system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors

2002 • 481 citations

Coupling Endoplasmic Reticulum Stress to the Cell Death Program

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Serial killers: ordering caspase activation events in apoptosis

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Shigella-induced Apoptosis Is Dependent on Caspase-1 Which Binds to IpaB

1998 • 407 citations

A bacterial invasin induces macrophage apoptosis by binding directly to ICE.

1996 • 405 citations

Caspase-1 Activation of IL-1β and IL-18 Are Essential for Shigella flexneri–Induced Inflammation

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Alice in caspase land. A phylogenetic analysis of caspases from worm to man

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Human caspase 12 has acquired deleterious mutations

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Caspases – controlling intracellular signals by protease zymogen activation

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Dual Role of Caspase-11 in Mediating Activation of Caspase-1 and Caspase-3 under Pathological Conditions

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IFNγ sensitizes for apoptosis by upregulating caspase-8 expression through the Stat1 pathway

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Response to local inflammation of IL-1 beta-converting enzyme- deficient mice.

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Structural basis for the activation of human procaspase-7

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Characterization of seven murine caspase family members

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Interferon γ Induces Upregulation and Activation of Caspases 1, 3, and 8 to Produce Apoptosis in Human Erythroid Progenitor Cells

1999 • 206 citations

The proteolytic procaspase activation network: an in vitro analysis

1999 • 195 citations

Interleukin-18 Regulation of Interferon γ Production and Cell Proliferation as Shown in Interleukin-1β–Converting Enzyme (Caspase-1)-Deficient Mice

1998 • 194 citations

Expression Analysis of the Human Caspase-1 Subfamily Reveals Specific Regulation of the CASP5 Gene by Lipopolysaccharide and Interferon-γ

2000 • 183 citations

Replication of a Cytopathic Strain of Bovine Viral Diarrhea Virus Activates PERK and Induces Endoplasmic Reticulum Stress-Mediated Apoptosis of MDBK Cells

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Macrophages Induce Cellular Immunity by Activating Th1 Cell Responses and Suppressing Th2 Cell Responses

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Inhibition of protein synthesis and early protein processing by thapsigargin in cultured cells

1993 • 157 citations

An endoplasmic reticulum-specific stress-activated caspase (caspase-12) is implicated in the apoptosis of A549 epithelial cells by respiratory syncytial virus

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Caspase-11 Gene Expression in Response to Lipopolysaccharide and Interferon-γ Requires Nuclear Factor-κB and Signal Transducer and Activator of Transcription (STAT) 1

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Interferon-gamma treatment elevates caspase-8 expression and sensitizes human breast tumor cells to a death receptor-induced mitochondria-operated apoptotic program.

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Caspase-11 Mediates Oligodendrocyte Cell Death and Pathogenesis of Autoimmune-Mediated Demyelination

2001 • 120 citations

Distinct downstream pathways of caspase-11 in regulating apoptosis and cytokine maturation during septic shock response

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Interferon-γ InducesIceGene Expression and Enhances Cellular Susceptibility to Apoptosis in the U937 Leukemia Cell Line

1996 • 110 citations

Caspases : their role in cell death and cell survival

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Na/Ca Exchanger Overexpression Induces Endoplasmic Reticulum–Related Apoptosis and Caspase-12 Activation in Insulin-Releasing BRIN-BD11 Cells

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Role of Caspase 1 in Murine Antibacterial Host Defenses and Lethal Endotoxemia

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Two discrete types of tumor necrosis factor-resistant cells derived from the same cell line.

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Induction of caspase‐11 by inflammatory stimuli in rat astrocytes: lipopolysaccharide induction through p38 mitogen‐activated protein kinase pathway

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Interleukin-1β-converting enzyme-deficient mice resist central but not systemic endotoxin-induced anorexia

1998 • 43 citations

Formation of noncanonical high molecular weight caspase-3 and -6 complexes and activation of caspase-12 during serum starvation induced apoptosis in AKR-2B mouse fibroblasts

2002 • 43 citations

Macrophage Biology and Pathobiology in the Evolution of Immune Responses: A Functional Analysis

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The caspase family

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Tumor-selective cytotoxic effects of murine tumor necrosis factor (TNF) and interferon-gamma (EN-gamma) in organ culture of B16 melanoma cells and heart tissue

1988 • 23 citations

The mouse antiphosphotyrosine immunoreactive kinase, TIK, is indistinguishable from the double-stranded RNAdependent, interferon-induced protein kinase, PKR

1993 • 20 citations