Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments

2004 • 11,620 citations

Mutations of the BRAF gene in human cancer

2002 • 10,249 citations

Epithelial–mesenchymal transitions in tumour progression

2002 • 6,431 citations

Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*

2001 • 3,897 citations

Dissemination and growth of cancer cells in metastatic sites

2002 • 3,796 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

Epidermal growth factor-related peptides and their receptors in human malignancies

1995 • 2,689 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

RAS oncogenes: the first 30 years

2003 • 1,788 citations

One Hundred and Twenty-Seven Cultured Human Tumor Cell Lines Producing Tumors in Nude Mice23

1977 • 1,556 citations

Hyperactive Ras in developmental disorders and cancer

2007 • 1,549 citations

Cetuximab in the treatment of colorectal cancer.

2004 • 1,501 citations

Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions

2001 • 1,385 citations

Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase

1994 • 1,370 citations

Agar suspension culture for the selective assay of cells transformed by polyoma virus

1964 • 1,265 citations

G1 cell-cycle control and cancer

2004 • 1,185 citations

uPAR: a versatile signalling orchestrator

2002 • 1,175 citations

Targeting the mitogen-activated protein kinase cascade to treat cancer

2004 • 1,093 citations

The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition

2007 • 1,044 citations

The MAPK signalling pathways and colorectal cancer

2005 • 998 citations

Breast Tumor Cell Lines From Pleural Effusions2

1974 • 973 citations

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

1999 • 970 citations

Classification of human colorectal adenocarcinoma cell lines.

1976 • 943 citations

Kirsten ras mutations in patients with colorectal cancer: the ‘RASCAL II’ study

2001 • 858 citations

Epithelioid cell cultures from rat small intestine. Characterization by morphologic and immunologic criteria.

1979 • 784 citations

Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis

2003 • 679 citations

Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis

2003 • 531 citations

Role of MAP kinase in tumor progression and invasion.

2003 • 508 citations

Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function

2003 • 466 citations

Influence of organ environment on the growth, selection, and metastasis of human colon carcinoma cells in nude mice.

1988 • 462 citations

Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review).

2003 • 390 citations

Mechanisms of apoptosis avoidance in cancer

1999 • 371 citations

RAS and RHO GTPases in G1-phase cell-cycle regulation

2004 • 346 citations

Matrix metalloproteinases: roles in cancer and metastasis

2006 • 269 citations

Rac-PAK Signaling Stimulates Extracellular Signal-Regulated Kinase (ERK) Activation by Regulating Formation of MEK1-ERK Complexes

2002 • 219 citations

Kirsten ras mutations in patients with colorectal cancer : the ‘RASCAL II’ study

2001 • 204 citations

The MAP kinase pathway is required for entry into mitosis and cell survival

2004 • 156 citations

Focus on colon cancer

2002 • 148 citations

Activation of the Raf-1/MAP kinase cascade is not sufficient for Ras transformation of RIE-1 epithelial cells.

1996 • 142 citations

Treatment of metastatic melanoma with an orally available inhibitor of the Ras-Raf-MAPK cascade.

2003 • 132 citations

Blockade of the Extracellular Signal-regulated Kinase Pathway Induces Marked G1 Cell Cycle Arrest and Apoptosis in Tumor Cells in Which the Pathway Is Constitutively Activated

2001 • 129 citations

Differential Regulation of P27Kip1 Expression by Mitogenic and Hypertrophic Factors

2000 • 129 citations

Selective Activation of MEK1 but Not MEK2 by A-Raf from Epidermal Growth Factor-stimulated Hela Cells

1996 • 120 citations

Activation of the Bcl-2 promoter by nerve growth factor is mediated by the p42/p44 MAPK cascade

1999 • 104 citations

Epidermal growth factor (EGF) suppresses staurosporine-induced apoptosis by inducing mcl-1 via the mitogen-activated protein kinase pathway

2000 • 99 citations

Expression of Activated MEK1 in Differentiating Epidermal Cells Is Sufficient to Generate Hyperproliferative and Inflammatory Skin Lesions

2004 • 87 citations

Nuclear Export of ERK3 by a CRM1-dependent Mechanism Regulates Its Inhibitory Action on Cell Cycle Progression

2003 • 78 citations

Dual role of MEK/ERK signaling in senescence and transformation of intestinal epithelial cells

2004 • 76 citations

Constitutively Active Mutant of the Mitogen-activated Protein Kinase Kinase MEK1 Induces Epithelial Dedifferentiation and Growth Inhibition in Madin-Darby Canine Kidney-C7 Cells

1997 • 73 citations

Mek1 Alters Epidermal Growth and Differentiation

2004 • 73 citations

Characterization of human colon carcinoma cell lines isolated from a single primary tumour

1983 • 72 citations

Constitutively active mitogen-activated protein kinase kinase MEK1 disrupts morphogenesis and induces an invasive phenotype in Madin-Darby canine kidney epithelial cells.

1999 • 71 citations

MEK1 signaling mediates transformation and metastasis of EpH4 mammary epithelial cells independent of an epithelial to mesenchymal transition.

2002 • 67 citations

In vivo activation of mitogen-activated protein kinases in rat intestinal neoplasia

1997 • 60 citations

Control of colorectal metastasis formation by K-Ras

2005 • 60 citations

Differential Regulation of Mitogen-Activated Protein/ERK Kinase (MEK)1 and MEK2 and Activation by a Ras-Independent Mechanism

1997 • 48 citations

p107 inhibits G1 to S phase progression by down-regulating expression of the F-box protein Skp2

2005 • 43 citations

Negative Regulation of MAPKK by Phosphorylation of a Conserved Serine Residue Equivalent to Ser212 of MEK1

2003 • 40 citations

Repression of mitogen-activated protein kinases ERK1/ERK2 activity by a protein tyrosine phosphatase in rat fibroblasts transformed by upstream oncoproteins

1998 • 37 citations

Oncogenic Potential of MEK1 in Rat Intestinal Epithelial Cells Is Mediated via Cyclooxygenase-2

2005 • 27 citations

In vivo models for early development of colorectal liver metastasis

2007 • 16 citations

Gene expression profiling following constitutive activation of MEK1 and transformation of rat intestinal epithelial cells

2006 • 13 citations