The MAPK signalling pathways and colorectal cancer

Mutations of the BRAF gene in human cancer

2002 • 10,249 citations

High Frequency of Mutations of the PIK3CA Gene in Human Cancers

2004 • 3,304 citations

Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase

1998 • 3,026 citations

Prevalence of ras gene mutations in human colorectal cancers

1987 • 1,866 citations

Signal Transduction through MAP Kinase Cascades

1998 • 1,762 citations

MAP Kinases in the Immune Response

2002 • 1,620 citations

Signal transduction by the c-Jun N-terminal kinase (JNK) — from inflammation to development

1998 • 1,551 citations

RAF/RAS oncogenes and mismatch-repair status

2002 • 1,205 citations

Cyclin D1 Expression Is Regulated Positively by the p42/p44 and Negatively by the p38/HOG Pathway

1996 • 1,203 citations

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

2001 • 1,181 citations

Detection of high incidence of K-ras oncogenes during human colon tumorigenesis

1987 • 1,074 citations

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

1999 • 970 citations

The Primary Structure of MEK, a Protein Kinase that Phosphorylates the ERK Gene Product

1992 • 931 citations

Prostaglandin E2 transactivates EGF receptor: A novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy

2002 • 846 citations

Kirsten ras Mutations in Patients With Colorectal Cancer: the Multicenter "RASCAL" Study

1998 • 739 citations

Ternary complex factors: growth factor regulated transcriptional activators

1994 • 686 citations

Phosphorylation of the MAP Kinase ERK2 Promotes Its Homodimerization and Nuclear Translocation

1998 • 675 citations

c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms

1999 • 662 citations

Raf-Induced Proliferation or Cell Cycle Arrest Is Determined by the Level of Raf Activity with Arrest Mediated by p21^Cip1

1997 • 643 citations

Defective Thymocyte Maturation in p44 MAP Kinase (Erk 1) Knockout Mice

1999 • 641 citations

Multicenter Phase II Study of the Oral MEK Inhibitor, CI-1040, in Patients With Advanced Non-Small-Cell Lung, Breast, Colon, and Pancreatic Cancer

2004 • 631 citations

The Sevenfold Way of PKC Regulation

1998 • 496 citations

Mutational Analysis of the Tyrosine Kinome in Colorectal Cancers

2003 • 487 citations

Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets

2002 • 429 citations

BRAF Mutation Is Frequently Present in Sporadic Colorectal Cancer with Methylated hMLH1, But Not in Hereditary Nonpolyposis Colorectal Cancer

2004 • 404 citations

The role of mitogen-activated protein (MAP) kinase in breast cancer

2002 • 393 citations

A pivotal role for ERK in the oncogenic behaviour of malignant melanoma?

2003 • 327 citations

Development of anticancer drugs targeting the MAP kinase pathway

2000 • 322 citations

Sodium salicylate induces apoptosis via p38 mitogen-activated protein kinase but inhibits tumor necrosis factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activation

1997 • 282 citations

Retinoic acid induced mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK) kinase-dependent MAP kinase activation needed to elicit HL-60 cell differentiation and growth arrest.

1998 • 254 citations

Mitogen-activated protein kinase/extracellular signal-regulated protein kinase activation by oncogenes, serum, and 12-O-tetradecanoylphorbol-13-acetate requires Raf and is necessary for transformation.

1994 • 237 citations

The Genetics of Colorectal Cancer

2002 • 237 citations

Phase III Double-Blind Placebo-Controlled Study of Farnesyl Transferase Inhibitor R115777 in Patients With Refractory Advanced Colorectal Cancer

2004 • 234 citations

The Stress-activated Protein Kinases p38α and JNK1 Stabilize p21Cip1 by Phosphorylation

2002 • 233 citations

CEP-1347 (KT7515), a Semisynthetic Inhibitor of the Mixed Lineage Kinase Family

2001 • 203 citations

Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3'-kinase/AKT signaling.

2003 • 201 citations

Mechanism of 17-β-Estradiol-induced Erk1/2 Activation in Breast Cancer Cells

2002 • 172 citations

Induction of Cell Proliferation in Quiescent NIH 3T3 Cells by Oncogenic c-Raf-1

1997 • 168 citations

Ursodeoxycholic Acid (UDCA) Can Inhibit Deoxycholic Acid (DCA)-induced Apoptosis via Modulation of EGFR/Raf-1/ERK Signaling in Human Colon Cancer Cells

2004 • 146 citations

Farnesyl transferase inhibitors: a novel targeted therapy for cancer

2001 • 141 citations

Insulin-like growth factor-I protects colon cancer cells from death factor-induced apoptosis by potentiating tumor necrosis factor alpha-induced mitogen-activated protein kinase and nuclear factor kappaB signaling pathways.

2000 • 139 citations

Up-regulation of Cyclooxygenase-2 and Apoptosis Resistance by p38 MAPK in Hypericin-mediated Photodynamic Therapy of Human Cancer Cells

2003 • 138 citations

Cyclic GMP mediates apoptosis induced by sulindac derivatives via activation of c-Jun NH2-terminal kinase 1.

2000 • 137 citations

Protein Kinase C (PKC) βII Induces Cell Invasion through a Ras/Mek-, PKCι/Rac 1-dependent Signaling Pathway

2004 • 132 citations

Expression of c-erbB receptors, heregulin and oestrogen receptor in human breast cell lines

2000 • 131 citations

Elevated ERK-MAP kinase activity protects the FOS family member FRA-1 against proteasomal degradation in colon carcinoma cells

2003 • 123 citations

Involvement of 3-Phosphoinositide-dependent Protein Kinase-1 in the MEK/MAPK Signal Transduction Pathway

2004 • 107 citations

Cyclic AMP Promotes cAMP-responsive Element-binding Protein-dependent Induction of Cellular Inhibitor of Apoptosis Protein-2 and Suppresses Apoptosis of Colon Cancer Cells through ERK1/2 and p38 MAPK

2004 • 105 citations

Induction of cIAP-2 in Human Colon Cancer Cells through PKCδ/NF-κB

2003 • 102 citations

Regulation of the Activity of p38 Mitogen-Activated Protein Kinase by Akt in Cancer and Adenoviral Protein E1A-Mediated Sensitization to Apoptosis

2003 • 98 citations

15-Lipoxygenase-1 Metabolites Down-regulate Peroxisome Proliferator-activated Receptor γ via the MAPK Signaling Pathway

2001 • 98 citations

Alterations of MAPK Activities Associated with Intestinal Cell Differentiation

2001 • 86 citations

Induction of S-phase arrest and p21 overexpression by a small molecule 2[[3-(2,3-dichlorophenoxy)propyl] amino]ethanol in correlation with activation of ERK

2004 • 85 citations

Diallyl Disulfide Induces ERK Phosphorylation and Alters Gene Expression Profiles in Human Colon Tumor Cells

2003 • 82 citations

Protein Kinase G Activates the JNK1 Pathway via Phosphorylation of MEKK1

2001 • 82 citations

Mitogen-activated protein kinase activation regulates intestinal epithelial differentiation

1999 • 80 citations

Downregulation of urokinase plasminogen activator receptor expression inhibits Erk signalling with concomitant suppression of invasiveness due to loss of uPAR–β1 integrin complex in colon cancer cells

2003 • 77 citations

Regulation of phorbol ester-mediated TRAF1 induction in human colon cancer cells through a PKC/RAF/ERK/NF-κB-dependent pathway

2004 • 76 citations

Growth-promoting effect of muscarinic acetylcholine receptors in colon cancer cells

2003 • 74 citations

Suppression of polyamine catabolism by activated Ki‐ras in human colon cancer cells

2004 • 70 citations

Ras/Raf signalling and emerging pharmacotherapeutic targets

2002 • 61 citations

Therapeutics targeting signal transduction for patients with colorectal carcinoma

2002 • 53 citations

Cell-type-specific activation of c-Jun N-terminal kinase by salicylates

1999 • 53 citations

Analysis of signaling protein kinases in human colon or colorectal carcinomas.

1998 • 51 citations

Opposing effects of butyrate and bile acids on apoptosis of human colon adenoma cells: differential activation of PKC and MAP kinases

2003 • 50 citations

Overexpression of keratinocyte growth factor in cancer cells and enterochromaffin cells in human colorectal cancer

2000 • 49 citations

MAP kinase pathway signalling is essential for extracellular matrix determined mammary epithelial cell survival

2000 • 48 citations

Activation of c‐Jun‐N‐terminal‐kinase is crucial for the induction of a cell cycle arrest in human colon carcinoma cells caused by flurbiprofen enantiomers

2003 • 45 citations

Epidermal growth factor induces c-fos and c-jun mRNA via Raf-1/MEK1/ERK-dependent and -independent pathways in bovine luteal cells

2003 • 42 citations

Epidermal growth factor upregulates matrix metalloproteinase-7 expression through activation of PEA3 transcription factors.

2004 • 40 citations

Integration of multiple downstream signals determines the net effect of insulin on MAP kinase vs. PI 3′-kinase activation: potential role of insulin-stimulated H2O2

2003 • 37 citations

Involvement of both extracellular signal‐regulated kinase and c‐jun N‐terminal kinase pathways in the 12‐O‐tetradecanoylphorbol‐13‐acetate–induced upregulation of p21^Cip1 in colon cancer cells

2002 • 37 citations

Activated Ki-Ras suppresses 12-O-tetradecanoylphorbol-13-acetate-induced activation of the c-Jun NH2-terminal kinase pathway in human colon cancer cells.

1999 • 34 citations

Sulindac sulfide inhibits epidermal growth factor-induced phosphorylation of extracellular-regulated kinase 1/2 and Bad in human colon cancer cells.

2003 • 32 citations

Expression of vascular endothelial growth factor, mitogen-activated protein kinase and p53 in human colorectal cancer.

2002 • 31 citations

ERK1/2 phosphorylation: a biomarker analysis within a phase I study with the new Raf kinase inhibitor BAY43-9006

2002 • 17 citations