Immunocytochemical evidence for translocation of protein kinase C in human megakaryoblastic leukemic cells: synergistic effects of Ca2+ and activators of protein kinase C on the plasma membrane association.

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C

1984 • 2,728 citations

Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate

1983 • 2,596 citations

Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane

1983 • 1,304 citations

Multiple, Distinct Forms of Bovine and Human Protein Kinase C Suggest Diversity in Cellular Signaling Pathways

1986 • 1,044 citations

Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester

1985 • 753 citations

Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation.

1983 • 705 citations

Cloning and expression of multiple protein kinase C cDNAs

1986 • 683 citations

Diacylglycerol and phorbol ester stimulate secretion without raising cytoplasmic free calcium in human platelets

1983 • 589 citations

[The role of protein kinase C in cell surface signal transduction and tumor promotion].

1986 • 508 citations

Tissue-specific expression of three distinct types of rabbit protein kinase C

1987 • 469 citations

A model for intracellular translocation of protein kinase C involving synergism between Ca2+ and phorbol esters

1985 • 446 citations

Isozymic forms of rat brain Ca2+-activated and phospholipid-dependent protein kinase.

1986 • 389 citations

Fate of immunoprecipitable protein kinase C in GH3 cells treated with phorbol 12-myristate 13-acetate.

1985 • 387 citations

Interleukin-2 stimulates association of protein kinase C with plasma membrane

1985 • 384 citations

Establishment of a novel human megakaryoblastic leukemia cell line, MEG- 01, with positive Philadelphia chromosome

1985 • 323 citations

Hormone-induced redistribution of calcium-activated phospholipid-dependent protein kinase in pituitary gonadotrophs.

1985 • 296 citations

Interaction of protein kinase C with membranes is regulated by Ca2+, phorbol esters, and ATP.

1985 • 274 citations

Altered cytosol/membrane enzyme redistribution on interleukin-3 activation of protein kinase C

1985 • 255 citations

Specificity and mechanism of protein kinase C activation by sn-1,2-diacylglycerols.

1986 • 254 citations

Cell type-specific expression of protein kinase C isozymes in the rabbit cerebellum.

1988 • 232 citations

The involvement of calpain in the activation of protein kinase C in neutrophils stimulated by phorbol myristic acid.

1986 • 228 citations

Dissociation of protein kinase C activation from phorbol ester-induced maturation of HL-60 leukemia cells.

1985 • 218 citations

Identification of the structures of multiple subspecies of protein kinase C expressed in rat brain

1987 • 202 citations

Down regulation of phorbol diester receptors by proteolytic degradation of protein kinase C in a cultured cell line of fetal rat skin keratinocytes.

1986 • 183 citations

Diacylglycerol modulates binding and phosphorylation of the epidermal growth factor receptor.

1984 • 168 citations

Purification and characterization of three types of protein kinase C from rabbit brain cytosol.

1987 • 168 citations

Association of protein kinase C with phospholipid vesicles

1987 • 149 citations

Thyrotropin-releasing hormone induces redistribution of protein kinase C in GH4C1 rat pituitary cells.

1985 • 140 citations

Translocation of protein kinase C during membrane immunoglobulin-mediated transmembrane signaling in B lymphocytes.

1986 • 136 citations

Failure of 1-oleoyl-2-acetylglycerol to mimic the cell-differentiating action of 12-O-tetradecanoylphorbol 13-acetate in HL-60 cells.

1985 • 125 citations

Activation of tracheal smooth muscle contraction: synergism between Ca2+ and activators of protein kinase C.

1985 • 123 citations

Functional and morphological differentiation induction of a human megakaryoblastic leukemia cell line (MEG-01s) by phorbol diesters

1988 • 113 citations

Isoquinolinesulfonamides, Novel and Potent Inhibitors of Cyclic Nucleotide-Dependent Protein Kinase and Protein Kinase C

1984 • 98 citations

Immunocytochemical evidence for phorbol ester-induced protein kinase C translocation in HL60 cells

1986 • 90 citations

Altered subcellular distribution of protein kinase C (a phorbol ester receptor). Possible role in tumor promotion and the regulation of cell growth: relationship to changes in adenylate cyclase activity.

1985 • 88 citations

Calcium as intracellular messenger: sensitivity modulation, C-kinase pathway, and sustained cellular response.

1984 • 79 citations

Cytosolic calcium regulates phorbol diester binding affinity in intact phagocytes.

1986 • 76 citations

Biosynthesis and secretion of functional protein S by a human megakaryoblastic cell line (MEG-01)

1987 • 67 citations

Aequorin detects increased cytoplasmic calcium in platelets stimulated with phorbol ester or diacylglycerol

1985 • 64 citations

[44] Transmembrane Ca2+ signaling and a new class of inhibitors

1987 • 47 citations

Ionomycin inhibits thyrotropin-releasing hormone-induced translocation of protein kinase C in GH4C1 pituitary cells.

1987 • 42 citations

Ca²⁺ and phorbol ester synergistically induce HL‐60 differentiation

1986 • 18 citations

Establishment of a novel human megakaryoblastic leukemia cell line, MEG- 01, with positive Philadelphia chromosome

1985 • 15 citations

Functional and morphological differentiation induction of a human megakaryoblastic leukemia cell line (MEG-01s) by phorbol diesters

1988 • 10 citations

Biosynthesis and secretion of functional protein S by a human megakaryoblastic cell line (MEG-01)

1987 • 5 citations

Protein kinase C and platelets.

1985 • 1 citations