Scrape-loaded p21ras down-regulates agonist-stimulated inositol phosphate production by a mechanism involving protein kinase C

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

ras GENES

1987 • 3,818 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides

1983 • 1,937 citations

A Cytoplasmic Protein Stimulates Normal N- ras p21 GTPase, But Does Not Affect Oncogenic Mutants

1987 • 1,197 citations

Induction of Membrane Ruffling and Fluid-Phase Pinocytosis in Quiescent Fibroblasts by ras Proteins

1986 • 725 citations

Comparative biochemical properties of normal and activated human ras p21 protein

1984 • 713 citations

Disappearance of Ca2+-sensitive, phospholipid-dependent protein kinase activity in phorbol ester-treated 3T3 cells

1984 • 643 citations

The p21 ras C-terminus is required for transformation and membrane association

1984 • 590 citations

Ras -Transformed Cells: Altered Levels of Phosphatidylinositol-4,5-Bisphosphate and Catabolites

1986 • 450 citations

Normal p21N-ras couples bombesin and other growth factor receptors to inositol phosphate production

1986 • 406 citations

Elevated levels of diacylglycerol and decreased phorbol ester sensitivity in ras-transformed fibroblasts

1987 • 330 citations

A method for incorporating macromolecules into adherent cells.

1984 • 307 citations

Novel source of 1,2-diacylglycerol elevated in cells transformed by Ha-ras oncogene

1987 • 303 citations

Involvement of functional protein kinase C in the mitogenic response to the H-ras oncogene product.

1987 • 131 citations

Opposing effects of a ras oncogene on growth factor-stimulated phosphoinositide hydrolysis: desensitization to platelet-derived growth factor and enhanced sensitivity to bradykinin.

1987 • 125 citations

Down-regulation of protein kinase C and of an endogenous 80-kDa substrate in transformed fibroblasts.

1987 • 119 citations

Protein kinase C-mediated negative-feedback inhibition of unstimulated and bombesin-stimulated polyphosphoinositide hydrolysis in Swiss-mouse 3T3 cells

1987 • 114 citations

Scrape-loading of Swiss 3T3 cells with ras protein rapidly activates protein kinase C in the absence of phosphoinositide hydrolysis.

1989 • 103 citations

Malignant transformation by ras and other oncogenes produces common alterations in inositol phospholipid signaling pathways.

1988 • 99 citations

Loss of platelet-derived growth factor-stimulated phospholipase activity in NIH-3T3 cells expressing the EJ-ras oncogene.

1987 • 63 citations

Mutant but not normal p21 ras elevates inositol phospholipid breakdown in two different cell systems.

1988 • 53 citations

NIH-3T3 cells transformed by the EJ-ras oncogene exhibit reduced platelet-derived growth factor-mediated Ca2+ mobilization.

1988 • 52 citations

Reduced protein kinase C activity in a ras-resistant cell line derived from Ki-MSV transformed cells.

1987 • 43 citations

Immunocytochemical localization in normal and transformed human cells in tissue culture using a monoclonal antibody to the src protein of the Harvey strain of Murine Sarcoma Virus

1983 • 28 citations

Desensitization of the Ca2+-mobilizing system to serum growth factors by Ha-ras and v-mos.

1988 • 25 citations

NIH-3T3 cells expressing high levels of the c- ras proto-oncogene display reduced platelet derived growth factor-stimulated phospholipase activity

1988 • 5 citations