Clearance of the original hepatitis B virus YMDD-motif mutants with emergence of distinct lamivudine-resistant mutants during prolonged lamivudine therapy

A One-Year Trial of Lamivudine for Chronic Hepatitis B

1998 • 1,779 citations

A Preliminary Trial of Lamivudine for Chronic Hepatitis B Infection

1995 • 820 citations

Inhibition of the replication of hepatitis B virus in vitro by 2',3'-dideoxy-3'-thiacytidine and related analogues.

1991 • 521 citations

Acute exacerbation and hepatitis B virus clearance after emergence of YMDD motif mutation during lamivudine therapy

1999 • 516 citations

Selection of mutations in the hepatitis B virus polymerase during therapy of transplant recipients with lamivudine

1996 • 470 citations

Mutation in HBV RNA-dependent DNA polymerase confers resistance to lamivudinein vivo

1996 • 454 citations

Emergence and takeover of YMDD motif mutant hepatitis B virus during long-term lamivudine therapy and re-takeover by wild type after cessation of therapy

1998 • 378 citations

Hepatitis B virus mutants associated with 3TC and famciclovir administration are replication defective

1998 • 374 citations

The preS2/S region of integrated hepatitis B virus DNA encodes a transcriptional transactivator

1990 • 284 citations

Lamivudine resistance inimmunocompetent chronic hepatitis B

1997 • 276 citations

Lack of effect of antiviral therapy in nondividing hepatocyte cultures on the closed circular DNA of woodchuck hepatitis virus

1997 • 261 citations

Biochemical pharmacology of (+)- and (-)-2',3'-dideoxy-3'-thiacytidine as anti-hepatitis B virus agents.

1992 • 199 citations

Mutation in HBV RNA-dependent DNA polymerase confers resistance to lamivudine in vivo

1996 • 173 citations

YMDD motif in hepatitis B virus DNA polymerase influences on replication and lamivudine resistance: A study byin vitrofull-length viral DNA transfection

1999 • 162 citations

Lamivudine Therapy of WHV-Infected Woodchucks

1998 • 157 citations

A trans-activator function is generated by integration of hepatitis B virus preS/S sequences in human hepatocellular carcinoma DNA.

1990 • 145 citations

The arginine-rich domain of hepatitis B virus precore and core proteins contains a signal for nuclear transport

1990 • 135 citations

Mechanism of inhibition of duck hepatitis B virus polymerase by (-)-beta-L-2',3'-dideoxy-3'-thiacytidine

1995 • 135 citations

Mutational pattern of hepatitis B virus on sequential therapy with famciclovir and lamivudine in patients with hepatitis B virus reinfection occurring under hbig immunoglobulin after liver transplantation

1999 • 127 citations

Role of Additional Mutations outside the YMDD Motif of Hepatitis B Virus Polymerase in l(−)SddC (3TC) Resistance

1998 • 123 citations

Identification of More than One Mutation in the Hepatitis B Virus Polymerase Gene Arising during Prolonged Lamivudine Treatment

1998 • 119 citations

Cell cycle regulation of nuclear localization of hepatitis B virus core protein.

1993 • 90 citations

BENEFICIAL EFFECT OF LAMIVUDINE IN RECURRENT HEPATITIS B AFTER LIVER TRANSPLANTATION

1997 • 71 citations

The hepatitis B virus pre-S/S(t) transactivator is generated by 3' truncations within a defined region of the S gene

1992 • 67 citations

Anti-HIV and Anti-HBV Activity and Resistance Profile of 2′,3′-Dideoxy-3′-Thiacytidine (3TC) and Its Arylphosphoramidate Derivative CF 1109

1996 • 62 citations

Mutations in the hepatitis B virus polymerase gene associated with antiviral treatment for hepatitis B

1999 • 49 citations

Two-year lamivudine therapy in chronic hepatitis B infection: Results of a placebo controlled multicentre study in Asia

1998 • 38 citations

Molecular cloning of a defective hepatitis C virus genome from the ascitic fluid of a patient with hepatocellular carcinoma.

1997 • 35 citations

G1 phase dependent nuclear localization of relaxed-circular hepatitis B virus DNA and aphidicolin-induced accumulation of covalently closed circular DNA

1998 • 33 citations

Nucleic Acid-Based Cross-Linking Assay for Detection and Quantification of Hepatitis B Virus DNA

1999 • 30 citations

Idiopathic Hemochromotosis and Alpha-1-Antitrypsin Deficiency: Coexistence in a Family with Progressive Liver Disease in the Proband

1983 • 27 citations

Phosphatidyl-2′,3′-dideoxy-3′-thiacytidine: synthesis and antiviral activity in hepatitis B- and HIV-1-infected cells

1995 • 23 citations

Emergence of an S Gene Mutant during Thymosin α₁Therapy in a Patient with Chronic Hepatitis B

1998 • 18 citations

Quantitative assessment of serum hepatitis B virus DNA: comparison between two different methods

1997 • 8 citations