Hepatitis B virus mutants associated with 3TC and famciclovir administration are replication defective

Current protocols in molecular biology

1988 • 4,543 citations

Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate

1982 • 1,429 citations

Identification of four conserved motifs among the RNA-dependent polymerase encoding elements.

1989 • 1,195 citations

Effect of Alpha-Interferon Treatment in Patients with Hepatitis B e Antigen-Positive Chronic Hepatitis B

1993 • 1,011 citations

A Preliminary Trial of Lamivudine for Chronic Hepatitis B Infection

1995 • 820 citations

Potential Mechanism for Sustained Antiretroviral Efficacy of AZT-3TC Combination Therapy

1995 • 637 citations

Inhibition of the replication of hepatitis B virus in vitro by 2',3'-dideoxy-3'-thiacytidine and related analogues.

1991 • 521 citations

Selection of mutations in the hepatitis B virus polymerase during therapy of transplant recipients with lamivudine

1996 • 470 citations

Hepatitis-B-virus resistance to lamivudine given for recurrent infection after orthotopic liver transplantation

1997 • 456 citations

Mutation in HBV RNA-dependent DNA polymerase confers resistance to lamivudinein vivo

1996 • 454 citations

Reduced replication of 3TC-resistant HIV-1 variants in primary cells due to a processivity defect of the reverse transcriptase enzyme.

1996 • 414 citations

Hydroxyurea as an Inhibitor of Human Immunodeficiency Virus-Type 1 Replication

1994 • 320 citations

The P gene product of hepatitis B virus is required as a structural component for genomic RNA encapsidation

1990 • 285 citations

Lamivudine Is Effective in Suppressing Hepatitis B Virus Dna in Chinese Hepatitis B Surface Antigen Carriers: A Placebo–Controlled Trial

1997 • 224 citations

Posttranscriptional regulation of hepatitis B virus replication by the precore protein

1997 • 177 citations

Hepatitis B virus polymerase mutations during antiviral therapy in a patient following liver transplantation

1997 • 149 citations

Effects of insertional and point mutations on the functions of the duck hepatitis B virus polymerase

1990 • 120 citations

Mutations in the epsilon sequences of human hepatitis B virus affect both RNA encapsidation and reverse transcription

1995 • 99 citations

Properties of Hepatitis B Virus Pre-S1 Deletion Mutants

1994 • 97 citations

Duck hepatitis B virus (DHBV) particles produced by transient expression of DHBV DNA in a human hepatoma cell line are infectious in vitro

1988 • 95 citations

Hepatitis B in an Oncology Unit

1974 • 95 citations

Generation of duck hepatitis B virus polymerase mutants through site-directed mutagenesis which demonstrate resistance to lamivudine [(--)-beta-L-2', 3'-dideoxy-3'-thiacytidine] in vitro

1996 • 68 citations

Characterization of Hepatitis B Virus Core Mutants That Inhibit Viral Replication

1994 • 53 citations

The implications of drug resistance for strategies of combination antiviral chemotherapy

1996 • 47 citations

Expression of infectious woodchuck hepatitis virus in murine and avian fibroblasts

1989 • 33 citations