Evolution of Hepatitis B Virus Polymerase Gene Mutations in Hepatitis B E Antigen-Negative Patients Receiving Lamivudine Therapy

A One-Year Trial of Lamivudine for Chronic Hepatitis B

1998 • 1,779 citations

LAMIVUDINE AS INITIAL TREATMENT FOR CHRONIC HEPATITIS B IN THE UNITED STATES

1999 • 1,119 citations

Identification and characterization of mutations in hepatitis B virus resistant to lamivudine

1998 • 808 citations

Complete Genomes, Phylogenetic Relatedness, and Structural Proteins of Six Strains of the Hepatitis B Virus, Four of Which Represent Two New Genotypes

1994 • 804 citations

Effects of extended lamivudine therapy in Asian patients with chronic hepatitis B

2000 • 708 citations

Hepatitis B e antigen–negative chronic hepatitis B

2001 • 564 citations

Rapid Changes in Human Immunodeficiency Virus Type 1 RNA Load and Appearance of Drug-Resistant Virus Populations in Persons Treated with Lamivudine (3TC)

1995 • 524 citations

Acute exacerbation and hepatitis B virus clearance after emergence of YMDD motif mutation during lamivudine therapy

1999 • 516 citations

Lamivudine and alpha interferon combination treatment of patients with chronic hepatitis B infection: a randomised trial

2000 • 503 citations

Efficacy of lamivudine in patients with hepatitis B e antigen-negative/hepatitis B virus DNA-positive (precore mutant) chronic hepatitis befficacy of lamivudine in patients with hepatitis B e antigen-negative/hepatitis B virus DNA-positive (precore mutant) chronic hepatitis befficacy of lamivudine in patients with hepatitis B e antigen-negative/hepatitis B virus DNA-positive (precore mutant) chronic hepatitis befficacy of lamivudine in patients with hepatitis B e antigen-negative/hepatitis B …

1999 • 481 citations

Lamivudine treatment for decompensated cirrhosis resulting from chronic hepatitis B

2000 • 422 citations

Reduced replication of 3TC-resistant HIV-1 variants in primary cells due to a processivity defect of the reverse transcriptase enzyme.

1996 • 414 citations

Emergence and takeover of YMDD motif mutant hepatitis B virus during long-term lamivudine therapy and re-takeover by wild type after cessation of therapy

1998 • 378 citations

Hepatitis B virus mutants associated with 3TC and famciclovir administration are replication defective

1998 • 374 citations

Hepatitis B virus S mutants in liver transplant recipients who were reinfected despite hepatitis B immune globulin prophylaxis

1998 • 324 citations

High-level resistance to (-) enantiomeric 2'-deoxy-3'-thiacytidine in vitro is due to one amino acid substitution in the catalytic site of human immunodeficiency virus type 1 reverse transcriptase

1993 • 320 citations

Multicenter Study of Lamivudine Therapy for Hepatitis B After Liver Transplantation

1999 • 291 citations

10-year follow-up after interferon-? therapy for chronic hepatitis C

1998 • 279 citations

Different hepatitis b virus genotypes are associated with different mutations in the core promoter and precore regions during hepatitis B e antigen seroconversion

1999 • 266 citations

Long-term follow-up of patients with anti-HBe/HBV DNA-positive chronic hepatitis B treated for 12 months with lamivudine

2000 • 246 citations

Mutations in hepatitis B DNA polymerase associated with resistance to lamivudine do not confer resistance to adefovirin vitro

1998 • 241 citations

Clearance of the original hepatitis B virus YMDD-motif mutants with emergence of distinct lamivudine-resistant mutants during prolonged lamivudine therapy

2000 • 220 citations

Hepatitis B e antigen-negative chronic hepatitis b in Hong Kong

2000 • 193 citations

YMDD motif in hepatitis B virus DNA polymerase influences on replication and lamivudine resistance: A study byin vitrofull-length viral DNA transfection

1999 • 162 citations

Initial appearance of the 184Ile variant in lamivudine-treated patients is caused by the mutational bias of human immunodeficiency virus type 1 reverse transcriptase

1997 • 147 citations

Susceptibility of lamivudine-resistant hepatitis B virus to other reverse transcriptase inhibitors

1999 • 135 citations

Lamivudine therapy in patients undergoing liver transplantation for hepatitis b virus precore mutant-associated infection: High resistance rates in treatment of recurrence but universal prevention if used as prophylaxis with very low dose hepatitis B immu

1999 • 115 citations

Lamivudine treatment for acute hepatitis B after liver transplantation

1998 • 73 citations

Antiviral chemotherapy for chronic hepatitis B infection: lessons learned from treating HIV-infected patients

1999 • 70 citations

Mutations in the hepatitis B virus polymerase gene associated with antiviral treatment for hepatitis B

1999 • 49 citations

Liver transplantation in HBsAg-positive HBV-DNA-negative cirrhotics: Immunoprophylaxis and long-term outcome

1996 • 28 citations