RETRACTED: ATP Hydrolysis-Dependent Disassembly of the 26S Proteasome Is Part of the Catalytic Cycle

Functional organization of the yeast proteome by systematic analysis of protein complexes

2002 • 4,751 citations

Structure of 20S proteasome from yeast at 2.4Å resolution

1997 • 2,211 citations

SPIDER and WEB: Processing and Visualization of Images in 3D Electron Microscopy and Related Fields

1996 • 2,073 citations

Recognition of the polyubiquitin proteolytic signal

2000 • 1,651 citations

Crystal Structure of the 20 S Proteasome from the Archaeon T. acidophilum at 3.4 Å Resolution

1995 • 1,513 citations

A Multiubiquitin Chain Is Confined to Specific Lysine in a Targeted Short-Lived Protein

1989 • 1,463 citations

F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex

1997 • 1,208 citations

Role of Rpn11 Metalloprotease in Deubiquitination and Degradation by the 26 S Proteasome

2002 • 983 citations

A Subcomplex of the Proteasome Regulatory Particle Required for Ubiquitin-Conjugate Degradation and Related to the COP9-Signalosome and eIF3

1998 • 901 citations

A gated channel into the proteasome core particle.

2000 • 791 citations

A 26 S protease subunit that binds ubiquitin conjugates.

1994 • 759 citations

Proteasomes and their kin: proteases in the machine age

2004 • 727 citations

A cryptic protease couples deubiquitination and degradation by the proteasome

2002 • 720 citations

Multiple Associated Proteins Regulate Proteasome Structure and Function

2002 • 633 citations

Proteasomal Proteomics: Identification of Nucleotide-sensitive Proteasome-interacting Proteins by Mass Spectrometric Analysis of Affinity-purified Proteasomes

2000 • 542 citations

Structural basis for the activation of 20S proteasomes by 11S regulators

2000 • 503 citations

The base of the proteasome regulatory particle exhibits chaperone-like activity

1999 • 485 citations

Multiubiquitin Chain Receptors Define a Layer of Substrate Selectivity in the Ubiquitin-Proteasome System

2004 • 450 citations

A proteasomal ATPase subunit recognizes the polyubiquitin degradation signal

2002 • 445 citations

The Axial Channel of the Proteasome Core Particle Is Gated by the Rpt2 ATPase and Controls Both Substrate Entry and Product Release

2001 • 413 citations

The Multiubiquitin-Chain-Binding Protein Mcb1 Is a Component of the 26S Proteasome in Saccharomyces cerevisiae and Plays a Nonessential, Substrate-Specific Role in Protein Turnover

1996 • 393 citations

ATP-Dependent Proteases Degrade Their Substrates by Processively Unraveling Them from the Degradation Signal

2001 • 392 citations

ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin.

1989 • 370 citations

Recruitment of a 19 S Proteasome Subcomplex to an Activated Promoter

2002 • 340 citations

The proteasome (multicatalytic protease) is a component of the 1500-kDa proteolytic complex which degrades ubiquitin-conjugated proteins.

1990 • 327 citations

Active site mutants in the six regulatory particle ATPases reveal multiple roles for ATP in the proteasome

1998 • 306 citations

Proteasome Active Sites Allosterically Regulate Each Other, Suggesting a Cyclical Bite-Chew Mechanism for Protein Breakdown

1999 • 282 citations

Structure of the Cand1-Cul1-Roc1 Complex Reveals Regulatory Mechanisms for the Assembly of the Multisubunit Cullin-Dependent Ubiquitin Ligases

2004 • 273 citations

The 19S Regulatory Particle of the Proteasome Is Required for Efficient Transcription Elongation by RNA Polymerase II

2001 • 266 citations

ATP Hydrolysis by the Proteasome Regulatory Complex PAN Serves Multiple Functions in Protein Degradation

2003 • 248 citations

Proteins Are Unfolded on the Surface of the ATPase Ring before Transport into the Proteasome

2001 • 235 citations

Proteasomal ATPases Link Ubiquitylation of Histone H2B to Methylation of Histone H3

2004 • 200 citations

The Caspase-like Sites of Proteasomes, Their Substrate Specificity, New Inhibitors and Substrates, and Allosteric Interactions with the Trypsin-like Sites

2003 • 186 citations

The HEAT repeat protein Blm10 regulates the yeast proteasome by capping the core particle

2005 • 182 citations

Physical association of ubiquitin ligases and the 26S proteasome

2000 • 178 citations

Binding of Hydrophobic Peptides to Several Non-catalytic Sites Promotes Peptide Hydrolysis by All Active Sites of 20 S Proteasomes

2002 • 173 citations

Nucleotide-Dependent Conformational Changes in a Protease-Associated ATPase HslU

2001 • 166 citations

A multicomponent system that degrades proteins conjugated to ubiquitin. Resolution of factors and evidence for ATP-dependent complex formation.

1988 • 161 citations

The 19S complex of the proteasome regulates nucleotide excision repair in yeast

2001 • 101 citations

Selective Degradation of Ubiquitinated Sic1 by Purified 26S Proteasome Yields Active S Phase Cyclin-Cdk

2001 • 99 citations

Assembly of the 26 S complex that degrades proteins ligated to ubiquitin is accompanied by the formation of ATPase activity.

1990 • 92 citations

Isolation and mass spectrometry of transcription factor complexes

2002 • 91 citations

UFD4 lacking the proteasome-binding region catalyses ubiquitination but is impaired in proteolysis

2002 • 87 citations

Cyclin-dependent kinase and Cks/Suc1 interact with the proteasome in yeast to control proteolysis of M-phase targets

1999 • 82 citations

Release of Ubiquitin-Charged Cdc34-S∼Ub from the RING Domain Is Essential for Ubiquitination of the SCFCdc4-Bound Substrate Sic1

2003 • 80 citations

26 S proteasomes function as stable entities 1 1Edited by R. Huber

2002 • 64 citations

ClpA and ClpP Remain Associated during Multiple Rounds of ATP-Dependent Protein Degradation by ClpAP Protease

1999 • 61 citations

Formation of Proteasome−PA700 Complexes Directly Correlates with Activation of Peptidase Activity

1998 • 59 citations

Nanoenzymology of the 20S Proteasome: Proteasomal Actions Are Controlled by the Allosteric Transition

2002 • 58 citations

Ligand Receptor Dynamics at Streptavidin-Coated Particle Surfaces: A Flow Cytometric and Spectrofluorimetric Study

1999 • 58 citations

Two-substrate association with the 20S proteasome at single-molecule level

2004 • 52 citations

Effects of nucleotides on assembly of the 26S proteasome and degradation of ubiquitin conjugates.

1997 • 8 citations