Blockade of melanocortin transmission inhibits cocaine reward

The neural basis of drug craving: An incentive-sensitization theory of addiction

1993 • 7,074 citations

Autoradiographic localization of dopamine D1 and D2 receptors in rat nucleus accumbens: Resistance to differential rearing conditions

1991 • 3,177 citations

Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice

1997 • 2,992 citations

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

1997 • 1,891 citations

Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli

1999 • 1,536 citations

The Neuroscience of Natural Rewards: Relevance to Addictive Drugs

2002 • 1,439 citations

Addiction and the brain: The neurobiology of compulsion and its persistence

2001 • 1,284 citations

Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain.

1994 • 1,059 citations

Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor

1994 • 1,055 citations

Regulation of Cocaine Reward by CREB

1998 • 762 citations

Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain

1994 • 703 citations

Ethology and neurobiology of grooming behavior

1992 • 690 citations

Molecular cloning of a novel melanocortin receptor.

1993 • 683 citations

Psychomotor stimulant addiction: a neural systems perspective.

2002 • 635 citations

Integration of NPY, AGRP, and Melanocortin Signals in the Hypothalamic Paraventricular Nucleus

1999 • 603 citations

Psychomotor Stimulant Addiction: A Neural Systems Perspective

2002 • 573 citations

Enhanced behavioural control by conditioned reinforcers following microinjections of d-amphetamine into the nucleus accumbens

1984 • 440 citations

Enhancement of Locomotor Activity and Conditioned Reward to Cocaine by Brain-Derived Neurotrophic Factor

1999 • 376 citations

alpha-Melanocyte stimulating hormone: immunohistochemical identification and mapping in neurons of rat brain.

1978 • 352 citations

Vertical Shifts in Self-Administration Dose–Response Functions Predict a Drug-Vulnerable Phenotype Predisposed to Addiction

2000 • 346 citations

Cyclic lactam .alpha.-melanotropin analogs of Ac-Nle4-cyclo[Asp5,D-Phe7,Lys10]-.alpha.-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors

1995 • 345 citations

6-Hydroxydopamine lesions of the nucleus accumbens, but not of the caudate nucleus, attenuate enhanced responding with reward-related stimuli produced by intra-accumbens d-amphetamine

1986 • 316 citations

Fos B mutant mice: Loss of chronic cocaine induction of Fos-related proteins and heightened sensitivity to cocaine’s psychomotor and rewarding effects

1997 • 283 citations

Sensitization to the conditioned rewarding effects of cocaine: pharmacological and temporal characteristics.

1995 • 263 citations

Total Recall--the Memory of Addiction

2001 • 175 citations

Relative roles of ventral striatal D1 and D2 dopamine receptors in responding with conditioned reinforcement

1993 • 161 citations

Enhanced responding for conditioned reward produced by intra-accumbens amphetamine is potentiated after cocaine sensitization

1999 • 143 citations

Morphine down-regulates melanocortin-4 receptor expression in brain regions that mediate opiate addiction.

1996 • 138 citations

Brain Melanocortin Receptors: From Cloning to Function

1997 • 138 citations

Distribution of α-melanocyte-stimulating hormone in the rat brain: Evidence that α-MSH-containing cells in the arcuate region send projections to extrahypothalamic areas

1979 • 136 citations

The MC4 receptor mediates α-MSH induced release of nucleus accumbens dopamine

2001 • 104 citations

Attenuation of morphine tolerance and dependence by α-melanocyte stimulating hormone (α-MSH)

1979 • 88 citations

Antagonism of morphine-induced analgesia, tolerance and dependence by alpha-melanocyte-stimulating hormone.

1984 • 83 citations

Melanocortins and opiate addiction

1997 • 57 citations

Molecular and Behavioral Interactions Between Central Melanocortins and Cocaine

2003 • 57 citations

The melanocortin receptor agonist MTII augments the rewarding effect of amphetamine in ad-libitum-fed and food-restricted rats

2002 • 49 citations

Alpha-MSH injected into the substantia nigra or intraventricularly alters behavior and the striatal dopaminergic activity

1986 • 47 citations

Role of dopamine in the regulation of proopiomelanocortin (POMC) mRNA levels in the arcuate nucleus and pituitary gland of the female rat as studied by in situ hybridization

1992 • 46 citations

Localization of cells preferentially expressing GAD67 with negligible GAD65 transcripts in the rat hippocampus. A double in situ hybridization study

1999 • 43 citations

Peptide-induced grooming behavior and caudate nucleus dopamine release

1993 • 28 citations

Adrenocorticotropin/α‐Melanocyte‐Stimulating Hormone (ACTH/MSH)‐Like Peptides Modulate Adenylate Cyclase Activity in Rat Brain Slices: Evidence for an ACTH/MSH Receptor‐Coupled Mechanism

1993 • 21 citations

α-MSH changes cyclic AMP levels in rat brain slices by an interaction with the D1 dopamine receptor

1995 • 15 citations

Intra-accumbens injections of ACTH induce excessive grooming in rats

1983 • 9 citations

Effects of Cocaine and Pimozide on Plasma and Brain Alpha-Melanocyte-Stimulating Hormone Levels in Rats

1992 • 9 citations

α-Melanotropin hormone inhibits the binding of []SCH 23390 to the dopamine D1 receptor in vitro

1998 • 9 citations

Structure-activity studies of α-melanotropin fragments on cAMP production in striatal slices

2000 • 3 citations