The melanocortin receptor agonist MTII augments the rewarding effect of amphetamine in ad-libitum-fed and food-restricted rats

The neural basis of drug craving: An incentive-sensitization theory of addiction

1993 • 7,074 citations

Central nervous system control of food intake

2000 • 6,305 citations

Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice

1997 • 2,992 citations

A psychomotor stimulant theory of addiction.

1987 • 2,704 citations

Identification of targets of leptin action in rat hypothalamus.

1996 • 1,502 citations

Hypothalamic CART is a new anorectic peptide regulated by leptin

1998 • 1,283 citations

From Lesions to Leptin

1999 • 1,165 citations

Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons

1998 • 1,136 citations

Intravenous cocaine, morphine, and amphetamine preferentially increase extracellular dopamine in the "shell" as compared with the "core" of the rat nucleus accumbens.

1995 • 857 citations

The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice

1998 • 802 citations

Leptin Activates Hypothalamic CART Neurons Projecting to the Spinal Cord

1998 • 797 citations

Addictive Drugs and Brain Stimulation Reward

1996 • 777 citations

Response of melanocortin–4 receptor–deficient mice to anorectic and orexigenic peptides

1999 • 549 citations

Regulation of Hypothalamic Proopiomelanocortin mRNA by Leptin in ob/ob Mice

1997 • 425 citations

Autoradiographic localization of insulin receptors in rat brain: Prominence in olfactory and limbic areas

1986 • 416 citations

Modulation of Brain Reward Circuitry by Leptin

2000 • 411 citations

Insulin and leptin: dual adiposity signals to the brain for the regulation of food intake and body weight

1999 • 398 citations

Hypothalamic Agouti-Related Protein Messenger Ribonucleic Acid Is Inhibited by Leptin and Stimulated by Fasting*

1999 • 374 citations

Self-injection of amphetamine directly into the brain

1983 • 373 citations

Feeding and hypothalamic stimulation increase dopamine turnover in the accumbens

1988 • 358 citations

Cyclic lactam .alpha.-melanotropin analogs of Ac-Nle4-cyclo[Asp5,D-Phe7,Lys10]-.alpha.-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors

1995 • 345 citations

Rewarding Actions of Phencyclidine and Related Drugs in Nucleus Accumbens Shell and Frontal Cortex

1996 • 331 citations

Dissociation of dopamine release in the nucleus accumbens from intracranial self-stimulation

1999 • 326 citations

Evidence That Separate Neural Circuits in the Nucleus Accumbens Encode Cocaine Versus “Natural” (Water and Food) Reward

2000 • 309 citations

Brainstem Application of Melanocortin Receptor Ligands Produces Long-Lasting Effects on Feeding and Body Weight

1998 • 279 citations

Increased Drug-Reinforced Behavior due to Food Deprivation

1984 • 271 citations

Stress-induced sensitization and glucocorticoids. I. Sensitization of dopamine-dependent locomotor effects of amphetamine and morphine depends on stress-induced corticosterone secretion

1995 • 261 citations

The curve-shift paradigm in self-stimulation

1986 • 250 citations

Immunohistochemical localization of leptin receptor in the rat brain

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Role of the CNS Melanocortin System in the Response to Overfeeding

1999 • 211 citations

Parametric analysis of brain stimulation reward in the rat: III. Effect of performance variables on the reward summation function.

1974 • 192 citations

Opiate agonists microinjected into the nucleus accumbens enhance sucrose drinking in rats

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Feeding effects of hypothalamic injection of melanocortin 4 receptor ligands

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Leptin Attenuates Acute Food Deprivation-Induced Relapse to Heroin Seeking

2001 • 184 citations

Food Restriction Enhances the Central Rewarding Effect of Abused Drugs

1998 • 182 citations

Central infusion of melanocortin agonist MTII in rats: assessment of c-Fos expression and taste aversion

1998 • 179 citations

Localization of 125I-insulin binding sites in the rat hypothalamus by quantitative autoradiography

1986 • 167 citations

Altered energy balance causes selective changes in melanocortin-4(MC4-R), but not melanocortin-3 (MC3-R), receptors in specific hypothalamic regions: further evidence that activation of MC4-R is a physiological inhibitor of feeding.

1999 • 144 citations

Morphine down-regulates melanocortin-4 receptor expression in brain regions that mediate opiate addiction.

1996 • 138 citations

Brain Melanocortin Receptors: From Cloning to Function

1997 • 138 citations

Selective Antagonist for the Melanocortin 4 Receptor (HS014) Increases Food Intake in Free-Feeding Rats

1998 • 128 citations

Food-deprivation increases cocaine-induced conditioned place preference and locomotor activity in rats

1997 • 126 citations

Feeding, drug abuse, and the sensitization of reward by metabolic need

1996 • 125 citations

Microinjections of phencyclidine (PCP) and related drugs into nucleus accumbens shell potentiate medial forebrain bundle brain stimulation reward

1996 • 123 citations

The MC4 receptor mediates α-MSH induced release of nucleus accumbens dopamine

2001 • 104 citations

Sucrose intake predicts rate of acquisition of cocaine self-administration

2000 • 82 citations

Chronic food restriction and weight loss produce opioid facilitation of perifornical hypothalamic self-stimulation

1993 • 78 citations

Intra-nucleus accumbens amphetamine: Dose-dependent effects on food intake

1986 • 73 citations

Analogs of MTII, Lactam Derivatives of α-Melanotropin, Modified at the N-Terminus, and Their Selectivity at Human Melanocortin Receptors 3, 4, and 5

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Intravenous morphine self-administration by rats with low versus high saccharin preferences

1995 • 68 citations

Effects of ketoconazole on the acquisition of intravenous cocaine self-administration under different feeding conditions in rats

2001 • 66 citations

Competition and summation between rewarding effects of sucrose and lateral hypothalamic stimulation in the rat.

1994 • 63 citations

Differential effects of melanocortin peptides on ingestive behaviour in rats: evidence against the involvement of MC3 receptor in the regulation of food intake

2000 • 63 citations

Melanocortins and opiate addiction

1997 • 57 citations

Individual differences in sugar intake predict the locomotor response to acute and repeated amphetamine administration

1994 • 57 citations

Diabetes decreases limbic extracellular dopamine in rats

1996 • 52 citations

Combined effects of buprenorphine and a nondrug alternative reinforcer on IV cocaine self-administration in rats maintained under FR schedules

1996 • 47 citations

Chronic food restriction in rats augments the central rewarding effect of cocaine and the δ 1 opioid agonist, DPDPE, but not the δ 2 agonist, deltorphin-II

2000 • 46 citations

Chronic food restriction increases Fos-like immunoreactivity (FLI) induced in rat forebrain by intraventricular amphetamine

2000 • 43 citations

TONIC PROPERTIES OF ***OROSENSATION AND THE MODULATION OF INTRACRANIAL SELF‐STIMULATION: THE CNS WEIGHTING OF EXTERNAL AND INTERNAL FACTORS GOVERNING REWARD

1977 • 36 citations

Neurotransmitter Transporters: Target for Endocrine Regulation

1999 • 31 citations

Peptide-induced grooming behavior and caudate nucleus dopamine release

1993 • 28 citations

Food intake and lateral hypothalamic self-stimulation covary after medial hypothalamic lesions or ventral midbrain 6-hydroxydopamine injections that cause obesity.

1989 • 27 citations

Mesolimbic dopaminergic mechanisms underlying individual differences in sugar consumption and amphetamine hyperlocomotion in Wistar rats

1998 • 18 citations

Intraventricular insulin reduces the antinociceptive effect of [d-Ala2, NMePhe4, Gly-ol5]enkephalin in mice

1998 • 7 citations

Structure-activity studies of α-melanotropin fragments on cAMP production in striatal slices

2000 • 3 citations